Abdulla A. Damluji, MD, PhD Profile picture
• I swam in Tigris River in the '90s. • Then, competitive swimmer • Now, physician-scientist (interventional cardiology) • @NYUStern EMBA'23 • Tweets are my own
Mar 23 13 tweets 3 min read
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary InterventionA Systematic Review and Patient-Level Meta-Analysis: @JAMACardio

🥸 Good morning: more on SAPT monotherapy vs DAPT

😱Summary

👇👇👇 Image 1.🥸 Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is standard post-PCI to minimize ischemic events, but it increases bleeding risk. Emerging studies prompt a reassessment.

😱 Mainly, in high risk groups: older adults.
Mar 14 22 tweets 4 min read
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials: @CircAHA

🥸wow: more on left main+diabetes: PCI vs CABG!

😱 Summary

👇👇👇 Image 1/ 🥸 Left main coronary artery disease and diabetes are associated with substantial cardiovascular morbidity and mortality.
Dec 3, 2023 21 tweets 3 min read
Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society: @CircAHA

🥸Great work: @AHA_Research @AHA_AcuteCVCare

😱Let's summarize: Happy Sunday :)

👇👇👇 Image 1/🥸 Cardiac Arrest Prevalence: Over 600,000 individuals in the US experience cardiac arrest annually.

😱This is a significant public health problem.
Nov 12, 2023 11 tweets 3 min read
Great #AHA23 so far: @AHA_Research

🥸8 Trials: 8 take aways below

Read the read👇👇

1/ATRESIA:

Patients with subclinical atrial fibrillation can benefit from apixaban to reduce the risk of stroke and systemic thromboembolism. Image 2/CARDIA-SSBP:

🥸The decline in SBP with a low-sodium diet was independent of hypertension status and anti-hypertensive medication use, consistent across subgroups, and did not result in excess adverse Image
Nov 11, 2023 19 tweets 3 min read
Semaglutide and Cardiovascular Outcomes
in Obesity without Diabetes: @NEJM

The select trial: #AHA23

🥸Wow! @AHA_Research

😱Now on the stage in main event

😱Let's get the highlights

👇👇👇 Image 1.🥸 GLP-1 receptor agonists are known for cardiovascular benefits in type 2 diabetes.
Oct 22, 2023 28 tweets 3 min read
Frailty-Guided Management of Cardiovascular Disease— From Clinical Trials to Clinical Practice: @JAMACardio

🥸More on this in @JACCJournals soon...

Discussion below -

👇👇 Image 🥸1. Frailty is a reduced physiological reserve and increased vulnerability to stressors.

😱 Important for CVD Management and Interventional Cardiology Procedures.
Oct 8, 2023 32 tweets 4 min read
Nondental Invasive Procedures and Risk of Infective Endocarditis: Time for a Revisit: A Science Advisory from the @American_Heart: @CircAHA

😱Can you please keep the summary less than 30 points?

🥸 I will try, but I do not want to.

😱🔫

Late Sunday summary below

👇👇👇 Image 1️⃣🥸😱 Infective endocarditis (IE) poses a risk of severe complications, and warrants prevention in high-risk patients.
Sep 18, 2023 36 tweets 5 min read
Impact of Complete Revascularization in the ISCHEMIA Trial: @JACCJournals

How do you interpret the results of this ischemia sub-study? The devil is in the detail. 😱

Good morning: 🥸

Below 👇👇 Image 🥸1. In the ISCHEMIA study, 43.4% and 58.4% of revascularization procedures met the criteria for Achieved Complete Revascularization and Functional Complete Revascularization, respectively.
Jul 7, 2023 26 tweets 4 min read
P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events: @JACCJournals

*** Great - this is what @AHAScience recommended for older higher risk patients: @MichaelGNanna

25-point summary in am report: (they are short sentences 😱)

👇👇👇 1/25 🥸 This meta-analysis of randomized controlled trials involved 24,325 participants with established coronary artery disease (CAD). Most received modern pharmaco-invasive treatments.
Jun 14, 2023 17 tweets 4 min read
Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease: @JACCJournals

My friend @MichaelGNanna is studying the effects of beta blockers and calcium channel blockers in older pts with SIHD: @PCORI

15-point summary 👇👇👇 Image 1/15 🥸 In a study of patients with stable coronary artery disease, beta-blocker therapy showed an 8% relative and 1.8% absolute risk reduction in all-cause mortality and hospitalization for heart failure or myocardial infarction over 5 years. Image
Jun 13, 2023 21 tweets 3 min read
Bioprosthetic Valve Remodeling in Nonfracturable Surgical Valves Impact on THV Expansion and Hydrodynamic Performance: @JACCJournals

Abbreviations

BVR = bioprosthetic valve remodeling
VIV = valve in valve
SHV = nonfracturable heart valve

Summary on this nice paper

👇👇🥸 Image 1/20 🥸 this study found that in Trifecta GT and Hancock II SHVs, BVR brought about limited improvement in THV expansion, largely dependent on the type of surgical valve and THV.
May 15, 2023 46 tweets 10 min read
Sarcopenia and Cardiovascular Diseases: @CircAHA

From the Geriatric Cardiology Leadership Council: @ACCinTouch

Main congratulations to @Dr_Alfaraidy: a board certified geriatrician and a cardiology fellow - she is amazing AND the best: @ParagGoyalMD 👏

Summary👇👇👇 Image 1/ 🚨 Sarcopenia is the loss of muscle strength, mass & function, worsened by chronic illness like CVD, kidney disease, & cancer 😷🩺
May 11, 2023 21 tweets 7 min read
Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease: @JACCJournals @NailaIjaz_MD

This analysis evaluated the timing of developing cognitive impairment & frailty in pts at risk for CAD!!

Summary 👇👇 Image 1/ In this @JACCJournals study, we examined the patterns of frailty and cognitive impairment (CI) development and their associations with cardiovascular outcomes in older adults without prior known coronary artery disease (CAD) during a 5-year follow-up. 🧠❤️

#NHATS
May 10, 2023 42 tweets 7 min read
Epidemiology of Diabetes and Atherosclerotic Cardiovascular Disease Among Asian American Adults: Implications, Management, and Future Directions: A Scientific Statement From the American Heart Association: @CircAHA

Nice statement on high risk group

Summary 👇👇👇 Image 1/ 🌏 Asian Americans (AsA) are the fastest growing ethnic group in the US 🇺🇸. They face high risks of Type 2 diabetes (T2D) & atherosclerotic cardiovascular disease (ASCVD) - major risks.
Apr 26, 2023 8 tweets 3 min read
Thread #2:

2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: @JACCJournals

* Easier to digest in small snippets, but not sure how to do this best, but let's experiment.

...continued starting from 13 through 18 Image 13/ Understanding HFpEF Diagnostic Challenges

❓Establishing a diagnosis of HFpEF may be difficult given the lack of obvious structural abnormalities and normal natriuretic peptide levels, especially in obese individuals.
Apr 26, 2023 14 tweets 3 min read
2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction A Report of the American College of Cardiology Solution Set Oversight Committee: @JACCJournals

Dense document, but will try to break it down w threads

Starting here👇👇👇 Image 1/The symptoms and signs of heart failure (HF) are best summarized by the Framingham HF Diagnostic Criteria.
Apr 24, 2023 8 tweets 2 min read
Long-Term Outcome of Drug-Coated Balloon vs Drug-Eluting Stent for Small Coronary Vessels: PICCOLETO-II 3-Year Follow-Up: @JACCJournals

The promise of drug coated balloons for small vessels (2 to 2.75mm)!

Summary 👇👇👇 Image 1/ 🚀PICCOLETO II is an open label, multi center, European clinical trial comparing novel paclitaxel drug coated balloons DCB to new-generation DES
Apr 4, 2023 8 tweets 2 min read
Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification: @CircAHA

Mechanistic study: Toll-Like Receptor 3 = TLR3

Here is few point summary

👇👇👇 Image 1/ 🧪 This study identifies TLR3 as a key element in aortic valve calcification. BGN, a central component of the extra cellular matrix (ECM), induces the TLR3 signaling cascade, resulting in valvular interstitial cells (VICs) transforming into bone-forming osteoblast-like cells.
Apr 3, 2023 7 tweets 2 min read
Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study: @CircAHA

5-point summary below: 👇👇 Image (1/5)

🚫 This trial is a single-arm, open label, phase IV clinical study that evaluated coronary atherosclerotic plaque regression with a PCSK9 inhibitor in asymptomatic patients with familial hypercholesterolemia (FH)
Apr 2, 2023 14 tweets 2 min read
Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort: @AnnalsofIM

Subclinical disease is common; CTA for prognostication!

Summary 👇👇👇👇 Image 1. This Danish study found that subclinical coronary atherosclerosis may be found in more than half of middle-aged men and one third of middle-aged women without known ischemic heart disease.
Mar 31, 2023 14 tweets 2 min read
Angina After Percutaneous Coronary Intervention: Patient and Procedural Predictors: @CircIntv

1 in 3 patients post FFR guided PCI had symptoms, but delta FFR (pre vs post) may be useful predictor of post PCI angina!

Here is 10 point summary 👇👇👇 1. The TARGET-FFR randomized trial found that one in three patients reported angina 3 months after undergoing percutaneous coronary intervention (PCI), which is a substantial proportion but reported previously in literature.