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Abdulla A. Damluji, MD, PhD Profile picture
@DrDamluji
Nov 4, 2021 • 5 tweets • 4 min read • Read on X
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EROSION III

OCT vs angiography

Study population: STEMI

Randomized 1:1

Outcomes MACCE at 1 month and 1 year

#TCT2021
Results
Secondary endpoint and procedural data
Limitations
Conclusions

• • •

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More from @DrDamluji

Abdulla A. Damluji, MD, PhD Profile picture
Dec 21
Atrial Fibrillation: @JAMA_current

🥸 Nice review in JAMA on AF by @darae_ko and team; congratulations.

😱 20-points here

👇👇👇 Image
🥸 1️⃣ Atrial fibrillation (AF) affects ~10.55 million US adults. It increases the risk of stroke, heart failure (HF), myocardial infarction, chronic kidney disease, dementia, and death.

😱Managing AF effectively is critical to improving CV outcomes.
🥸 2️⃣ AF symptoms range from palpitations, shortness of breath, chest pain, presyncope, and fatigue to being completely asymptomatic.

😱About 10-40% of people with AF don’t notice symptoms, which makes screening and incidental detection critical.
Read 23 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 17
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity: @NEJM

🥸The SUMMIT trial - @AHAScience

😱 Summary

👇👇👇 Image
🥸 1️⃣ Obesity drives heart failure with preserved ejection fraction (HFpEF) through systemic inflammation and visceral adiposity. Tirzepatide, a dual GIP and GLP-1 receptor agonist, offers weight loss and potential cardiovascular benefits.
🥸 2️⃣ The SUMMIT trial evaluated 731 HFpEF patients with obesity (BMI ≥30), randomized to tirzepatide or placebo for 52 weeks. Primary outcomes were a composite of cardiovascular death or worsening HF events and improvement in health status (KCCQ-CSS).
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 17
Left Atrial Appendage Closure after Ablation for Atrial Fibrillation: @NEJM

🥸The OPTION trial: @AHAScience

😱 Summary

👇👇👇👇 Image
🥸 1️⃣ Oral anticoagulation is standard after atrial fibrillation (AF) ablation for stroke prevention but comes with bleeding risks and patient burdens. Left atrial appendage closure (LAAC) offers an alternative, but data comparing these strategies post-ablation have been limited.
🥸 2️⃣ The OPTION trial evaluated 1,600 patients post-AF ablation, randomized to LAAC (device group) or oral anticoagulation (anticoagulation group). Patients had a CHA2DS2-VASc score ≥2 (men) or ≥3 (women), indicating moderate-to-high stroke risk.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 17
Routine Spironolactone in Acute Myocardial Infarction: @NEJM

🥸 Great trials from #AHA24: @AHASc

😱 Summary

👇👇👇 Image
🥸 1️⃣ Aldosterone levels predict worse outcomes after myocardial infarction (MI).

😱High levels are associated with increased mortality, and therapies targeting aldosterone have shown promise in other cardiovascular conditions.
🥸 2️⃣ Spironolactone has reduced mortality in patients with chronic heart failure with reduced ejection fraction (HFrEF).

😱It’s a cornerstone therapy for managing HFrEF and reducing hospitalizations.
Read 22 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Nov 1
Transcatheter Valve Replacement in Severe Tricuspid Regurgitation: @NEJM

🥸 TRISCEND II Trial - #TCT2024

😱 Summary

👇👇👇 Image
🥸 1️⃣ Severe tricuspid regurgitation leads to high symptom burden and increases risk of mortality.
🥸 2️⃣ This trial compared 400 patients with tricuspid regurgitation: valve replacement + medical therapy vs. medical therapy alone.
Read 17 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Oct 28
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis: @NEJM

🥸 I was at #TCT2024 all day - just got to a desk @TCTMD

😱 Summary of EARLY TAVR trial

👇👇👇 Image
🥸1️⃣ The EARLY TAVR trial focused on patients with asymptomatic severe aortic stenosis and preserved LV function to see if early transcatheter aortic-valve replacement (TAVR) outperformed standard surveillance.
🥸2️⃣ 901 patients (75.8 years average) were randomly split: 455 received early TAVR, 446 were under clinical surveillance per current guidelines, with close monitoring for worsening symptoms or health declines.
Read 21 tweets

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