Comparison of a Pure Plug-Based versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial
Tenecteplase for Ischemic Stroke at 4.5 to 24 Hours without Thrombectomy: @NEJM
🥸 There are many parallels between ischemic strokes and ACS Mx
😱Summary and have a nice Sunday
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🥸 1️⃣ Intravenous thrombolytic agents, such as alteplase, are recommended for eligible patients to be administered within 4.5 hours after the onset of an acute ischemic stroke to maximize the chances of recovery.
🥸 2️⃣ Tenecteplase, a genetically modified form of human tissue plasminogen activator, has been shown to be noninferior to alteplase for the treatment of ischemic stroke.
Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary InterventionA Systematic Review and Patient-Level Meta-Analysis: @JAMACardio
🥸 Good morning: more on SAPT monotherapy vs DAPT
😱Summary
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1.🥸 Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor is standard post-PCI to minimize ischemic events, but it increases bleeding risk. Emerging studies prompt a reassessment.
😱 Mainly, in high risk groups: older adults.
2. 🥸 Short DAPT durations followed by P2Y12 inhibitor monotherapy have shown promising reductions in bleeding but raised concerns re ischemic risks in high-risk patients.
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials: @CircAHA
🥸wow: more on left main+diabetes: PCI vs CABG!
😱 Summary
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1/ 🥸 Left main coronary artery disease and diabetes are associated with substantial cardiovascular morbidity and mortality.
2/ 🥸 Yet, long-term outcomes for patients with left main disease and diabetes undergoing PCI compared with CABG remain unclear.
Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society: @CircAHA
🥸Great work: @AHA_Research @AHA_AcuteCVCare
😱Let's summarize: Happy Sunday :)
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1/🥸 Cardiac Arrest Prevalence: Over 600,000 individuals in the US experience cardiac arrest annually.
😱This is a significant public health problem.
2/ 🥸 Worldwide Incidence: Globally, cardiac arrest occurs in 30 to 97 individuals per 100,000 population.
Patients with subclinical atrial fibrillation can benefit from apixaban to reduce the risk of stroke and systemic thromboembolism.
2/CARDIA-SSBP:
🥸The decline in SBP with a low-sodium diet was independent of hypertension status and anti-hypertensive medication use, consistent across subgroups, and did not result in excess adverse
3/ CRHCP:
🥸Intensive BP lowering (target BP < 130/80 mm Hg) significantly reduced risk of all-cause dementia among patients with hypertension, supporting the use of intensive hypertension treatment to reduce the burden of dementia.
Semaglutide and Cardiovascular Outcomes
in Obesity without Diabetes: @NEJM
The select trial: #AHA23
🥸Wow! @AHA_Research
😱Now on the stage in main event
😱Let's get the highlights
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1.🥸 GLP-1 receptor agonists are known for cardiovascular benefits in type 2 diabetes.
2.🥸 The SELECT trial tested semaglutide, a potent member of GLP-1 class of drugs, for cardiovascular risk in overweight individuals without diabetes history.