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Abdulla A. Damluji, MD, PhD Profile picture
@DrDamluji
Nov 5, 2021 • 26 tweets • 17 min read • Read on X
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SURTAVI

No differences in death ,stroke, MI, or HF between TAVR and Surgery during longer follow-up

#TCT2021
Hemodynamics

Total AR and PVL

KCCQ no difference after 1 year

NYHA class at one year 1
Summary for SURTAVI

Self expanding valve

#TCT2021
Excellent!
5 year data for 4,000 patients is now out (intermediate risk).

@djc795
Economic outcomes of PARTNER #3

@djc795

Cost effectiveness study along side of PARTNER 3 trial

funded by Edwards
Costing: definitions

US population only

Medicare data link
Results Baseline

TAVR vs SAVR PARTNER 3 Economic Study
Index Hospital Costs

Follow-up Cost
Overall no cost difference

QALY difference (borderline?!)

#TCT2021
All costs and effects discounting

TAVR is cost effective
Subgroups (pre-specified)

Sensitivity analyses

#TCT2021
Sensitivity Analyses
Summary!

84% CI that we will improve outcomes and at the same time achieve cost effectiveness.

10 year outcomes will affect cost effectiveness - to come...

Outstanding presentation @djc795 @DrMauricioCohen

#TCT2021
"When mortality rate is the same between SAVR and TAVR: patient preference is what matter next."

"No one wants a sternotomy."

@djc795

#TCT2021
CHOICE CLOSURE

Vascular Closure for TAVR but this also applies to shock space also (Safety Bundle)

#TCT2021

@Radial_ICG @behnam_tehrani @agtruesdell @ShashankSinhaMD @JACCJournals
Available Evidence

Aim Choice Closure

Randomization: pure plug based vs primary suture based

#TCT2021
Inclusion and Exclusion

Primary Endpoint
Secondary Endpoints

Study Methods

Angioseal was used...

3 Locations in Germany

#TCT2021
Study Flow

258 MANTA vs 258 ProGlide

#TCT2021
Baseline Results

Vessel Characteristics

Procedural Details

Low ultrasound use?! @Radial_ICG

#TCT2021
Manta had higher complications!!

Important data!

#TCT2021
Subgroup analysis

Hospital Outcomes

30-Day Outcomes

#TCT2021
Limitation
Conclusion

Excellent trial @Mo_A_W

Applies to shock too

***Editorializing: Losing the wire access with MANTA is a big problem.

#SafetyBundle

#TCT2021
Comparison of a Pure Plug-Based versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial

@CircAHA

ahajournals.org/doi/abs/10.116…

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More from @DrDamluji

Abdulla A. Damluji, MD, PhD Profile picture
Sep 7
Clopidogrel versus aspirin for secondary prevention of coronary artery disease: a systematic review and individual patient data meta-analysis: @TheLancet

🥸Plavix for secondary prevention may be superior to aspirin

😱 Summary

👇👇👇 Image
🥸1️⃣ For decades, aspirin has been the default long-term therapy for preventing recurrent cardiovascular events in patients with established coronary artery disease. It has been embedded in clinical guidelines based largely on historical data.
🥸2️⃣ However, multiple randomized trials have recently compared clopidogrel directly with aspirin as a single-agent strategy. This 2025 meta-analysis provides the most comprehensive assessment to date by combining patient-level data.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Sep 3
Global Uptake of GLP-1 Receptor Agonists in Obese, Non-Diabetic Patients with Cardiovascular Disease: @ESC_Journals

🥸New publication from our @heartwiselab research group: @MichaelGNanna

😱Older adults use: 1.9% of semaglutide and 1.3% of tirzepatide - summary

👇👇👇 Image
🥸1️⃣ GLP-1 receptor agonists (GLP-1RAs) were originally developed for diabetes and weight loss. SELECT expanded their role, showing semaglutide reduces cardiovascular events in non-diabetic patients with obesity and established cardiovascular disease.
🥸2️⃣ SELECT enrolled 17,604 adults ≥45 years with overweight or obesity (BMI ≥27) and prior MI, stroke, or PAD, but no diabetes. Semaglutide led to a 20% relative risk reduction in major adverse cardiovascular events.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Aug 30
Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias: @NEJM

🥸 The statement: "Keep K above 4 and Mg above 2" still holds: #ESCCongress2025

😱 Summary

👇👇👇 Image
🥸1️⃣ The POTCAST trial tested if raising potassium to the high-normal range (4.5–5.0 mmol/L) reduces malignant arrhythmias, hospitalizations, or death in patients with cardiovascular disease and an implanted defibrillator.
🥸2️⃣ It was a randomized, multicenter trial in Denmark enrolling 1,200 patients with potassium ≤4.3 mmol/L and an implantable cardioverter-defibrillator for primary or secondary prevention.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Aug 30
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction: @NEJM #ESCCongress2025

🥸 Does REBOOT-CNIC agree with BETAMI-DANBLOCK?

👇👇👇 Image
🥸1️⃣ The REBOOT trial evaluated beta-blockers after MI in patients with LVEF >40%. The trial tested whether routine beta-blockers reduce death, reinfarction, or heart failure hospitalization.
🥸2️⃣REBOOT enrolled 8,438 patients with recent MI and LVEF >40%, across 109 centers in Spain and Italy. All underwent coronary angiography and received modern secondary prevention therapy. The design was PROBE: randomized, open-label, blinded endpoint adjudication.
Read 21 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Aug 30
Beta-Blockers after Myocardial Infarction in Patients without Heart Failure: @NEJM @ESCCongress

🥸 Is evidence still in favor of beta blockers post AMI? #ESCCongress2025

😱Summary

👇👇👇 Image
🥸 1️⃣ The BETAMI–DANBLOCK trial, a large, pragmatic randomized trial from Denmark and Norway, asked whether long-term beta-blockers reduce death or cardiovascular events in post-MI patients with preserved or mildly reduced LVEF but no heart failure.
🥸 2️⃣ 5,574 patients with recent MI and LVEF ≥40% were randomized 1:1 to beta-blocker therapy or no beta-blockers within 14 days of the event, with outcomes tracked using complete national registry data and blinded adjudication.
Read 22 tweets
Abdulla A. Damluji, MD, PhD Profile picture
Aug 13
Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial: @ESC_Journals

🥸Aspirin for primary prevention for older pts = MACE!

👇👇👇👇 Image
🥸1️⃣ ASPREE was a large randomized trial designed to evaluate whether daily low-dose aspirin prevents cardiovascular events in initially healthy older adults.
🥸2️⃣ ASPREE enrolled 19,114 community-dwelling adults ≥70 (≥65 for US minorities), free of prior cardiovascular disease, dementia, or disability. Participants were randomized to 100 mg aspirin or placebo and followed in-trial (median 4.7 yrs) and post-trial (median 4.3 yrs).
Read 21 tweets

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