The @nytimes published "What We Know So Far About
Waning Vaccine Effectiveness" today
It is misleading and missing key reports from New York State, Veterans Affairs, Puerto Rico, Israel, Qatar, the UK, and several others nytimes.com/interactive/20…
Exemplifies bad messaging, skewed, incomplete data.
No, it's not true that "vaccines still offer strong protection against severe Covid-19" which is why the majority of at-risk US people (such as age 60+, past 6 months from 💉💉) have not gotten boosters yet
For months the media & many experts insisted the vaccines were fully protective vs severe disease while the evidence was pointing against that assertion. Still today @nytimes! No wonder the public is confused and booster uptake is low. Only 32% in the highest risk age group, 65+
Incredible "What We Know So Far About Waning Vaccine Effectiveness" is front page @nytimes tomorrow, missing many reports (as noted in🧵) asserting the waning is only vs infection in some people, when it is across all age groups and for severe disease, the basis for boosters😲
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As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile)
A Table from the post
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature nature.com/articles/s4158… nature.com/articles/d4158…