Graham Pechenik Profile picture
Nov 18, 2021 12 tweets 5 min read Read on X
Ibogaine + MDA = “an extremely beneficial drug”?

#TBT to 1968 patents by Claudio Naranjo

“The medical preparation of the invention produces most unexpected and beneficial results, by for example alleviating fears and anxieties which may have been present in the patient”

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The patents claimed medical preparations of:

(1) ibogaine, iboga alkaloid extract, or total extract; plus

(2) amphetamine, MDA, TMA, tetrahydronapthylamine, or naphazoline

“The best results have been obtained with” MDA

The combination “forms an excellent medicine"

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The ibogaine “has the effect of considerably clarifying the mind of the sick person, giving him a kind of extra-lucid vision of his ‘ego.’ It likewise excites the memory centre of the brain thus revealing memories which may go back to a period before the age of 4…”

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“The amphetamine derivative associated with the iboga extract, on the other hand, permits the emotional character necessary as complement to the stimulation of the mind and imagination as produced by the iboga to be restored to the patient.”

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“A toxicological study of the product has showed that secondary effects, e.g. vomiting & vertigo, are almost non-existent & that the medicine showed absolutely no danger as regards life or the biological balance of the invalid. The toxicity of this association is thus nil.”

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“In view of the extreme efficiency of the medicine, it seems pointless to visualise treatments of long duration.

The medicine, when used in psychotherapy, is in fact outstanding…at no time should the practician need to exceed 5 psychotherapy sessions…”

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“The spheres of application are immense.

Numerous clinical tests show that the medicine can be used in all diseases of psychosomatic character or of which the psychosomatic origin can be visualised.”

More than 50 cases were studied in psychiatry with 50 mental patients…”

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Case 1:

“A woman aged 35 years was treated for symptoms corresponding to an anxiety neurosis”

5 preparatory sessions, 3 drug sessions, “one or two interviews”

“Conclusion: No re-appearance of fears and a considerable improvement in the characterological difficulties."

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Case 2:

“A woman aged 23 years attended bc of conflicts w her husband. She envisaged the possibility of divorce…before taking action, she decided to find out to what point her actual refusal to her husband could be the consequence of personal psychological difficulties.”

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Case 3:

“A man aged 30 years was affected by sexual troubles, homosexual tendency & sexual unsatisfaction in his conjugal life.

One treatment session which comprised a dosage of total extract of the iboga combined w MDA produced a substantial improvement to his problem.”

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“Pioneering psychedelic therapist” Claudio Naranjo:

“psychiatrist & pioneer in the integration of psychotherapy, spirituality, & psychedelic experiences”

“helped train MAPS’ first therapist team for MDMA-assisted psychotherapy for PTSD” in Spain

maps.org/news/posts/781…

11/12
First filed on January 31, 1968 in France, Naranjo’s application was eventually granted in France, Belgium, Germany, Canada, & the UK

worldwide.espacenet.com/patent/search/…

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More from @calyxlaw

Jan 19, 2023
What happens when two companies’ patents both cover the same drug?

Reunion Neuroscience’s lead RE104 = isoprocin glutarate, a prodrug of 4-OH-DiPT

Reunion $REUN has a granted patent claiming it

Today, Mindset Pharma $MSET received a notice of allowance on claims to it too

1/7
Field Trip $FTRP (the original applicant) obtained its patent on RE104 (then FT-104) after first w/drawing it from issuance to ensure examiner reviewed Mindset’s apps

Mindset’s were filed first, but only published after Field Trip’s app was allowed

Patent was allowed again

2/7
After Field Trip received its patent, Mindset filed a continuation application adding new claims

One of those claims is to isoprocin glutarate, Field Trip’s prodrug of 4-OH-DiPT

Today, that claim was allowed

Mindset paid the issue fee immediately

A patent will issue soon

3/7
Read 8 tweets
Jun 22, 2022
MDMA + LSD = a patentable invention?

According to the USPTO, yes

Today—MindMed $MNMD granted a US patent, with claims to:

“A composition comprising an empathogen/entactogen and a psychedelic in the same single oral dosage form.”

Along with methods of using it

🍬🤸🏻

1/9
What’s the patentable invention?

According to MindMed, that the entactogen & the psychedelic are in “the same single oral dosage form”

By contrast: “Recreational users use MDMA & LSD in separate dosage forms.”

A single dosage form ≠ “a single session of substance abuse”

2/x
But what about all the prior art on candyflipping?

Indeed—@_PortaSophia filed a third-party submission to challenge MindMed’s claims, citing 20 references

However, MindMed already split off this sister app, under accelerated examination program

It was allowed 1 week later

3/9
Read 9 tweets
Feb 2, 2022
All your vapes are belong to us?

New patent granted—“Delivery System for Ayahuasca-Like Substances”

Claims DMT vapes, 5-MeO-DMT vapes, & 2C-B vapes

These claims can be immediately enforced

1/6
The patent claims:

“A device for the delivery of a substance comprising:

a chamber comprising at least one vaporizable formulation wherein the vaporizable formulation comprises the substance and wherein the substance comprises one or more of”

DMT, 5-MeO-DMT, or 2C-B

2/6
The application was first filed as a provisional in July 2020

Did DMT vape pens exist in the prior art before the priority date?

This @doubleblindmag article was first published on Feb. 5, 2020:

3/6
doubleblindmag.com/are-dmt-vape-p…
Read 6 tweets
Dec 31, 2021
Patentable pharmahuasca “kits of parts”?

New PCT app published: “Compositions & Kits of Parts Comprising N,N-DMT & Harmine & Their Use in Therapy”

“An alternative to ayahuasca that solves the problems of side effects…is pharmahuasca, also known as synthetic ayahuasca”

1/4
Applicant is University of Zürich, w inventors Dario Dornbierer, Davor Kosanic, & Milan Scheidegger

All are founders at Reconnect Labs: “a Spin-off of the University of Zürich…setting standards for a novel kind of ethical drug development company”

reconnect-foundation.org/reconnect-labs/

2/4
The PCT app claims:

–a “kit of parts” of DMT & harmine

–a composition of DMT & harmine

-their use to treat psychiatric disorders

None were found inventive

3/4
Read 4 tweets
Dec 30, 2021
New psychedelic inventions?

∰ Field Trip—tryptamine prodrugs

∰ Greenway DNA—personalized psychedelic treatment

∰ Small Pharma—deuterated DMT

1/9
Field Trip $FTRP: “Tryptamine Prodrugs”

Application covers diacid hemiester prodrugs of tryptamines & isotryptamines, eg, psilocin, 4-HO-DET, 4-HO-DiPT, & 4-HO-MiPT

Head twitch response & pharmacokinetics in rats & humans with 4-hemiglutarate & 4-hemisuccinate of 4-HO-DiPT

2/9
Is Field Trip $FTRP FT-104 a prodrug of 4-HO-DiPT?

In “Use in Treatment,” app discloses intramuscular & subcutaneous injection or oral tablet administration of:

N,N-isopropyltryptamine-4-glutarate (4-hemiglutarate of 4-HO-DiPT)

& subcutaneous “injectable formulation kit”

3/9
Read 9 tweets
Dec 29, 2021
New psychedelic inventions?

⁂ Phil Wolfson/KRF—ketamine for postpartum symptoms

⁂ Psilo Scientific—psychoactive & psychedelic fungus extraction

⁂ Cognigenics—5-HT2A “cognitive upgrade”

⁂ Liechti—MDMA response prediction

⁂ Small Pharma—DMT-type compound synthesis

1/14
…and more new psychedelic inventions?

⁂ Ixtlan—psilocybin for Alzheimer’s

⁂ Spirify—hydroxynorketamine analogs

⁂ Guangzhou Dazhou Biomedicine—transdermal ketamine

⁂ Disruption Labs—nanoparticle compositions

⁂ Daniel Lilly—“medicinal food products” with psilocybin

2/14
Ketamine Research Foundation (KRF)—“Ketamine for the Treatment of Postpartum Symptoms & Disorder”

First inventor Phil Wolfson

“treatment of all forms of emotional and psychological symptoms and disorders related to childbirth and its aftermath”

patentscope.wipo.int/search/en/deta…

3/14
Read 14 tweets

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