I’m a scientist and I have 2 kids that are between 5 and 11 years old. I respect that some parents have concerns about COVID-19 mRNA vaccines for their young children. Here is a short thread why my wife and I decided to vaccinate both of our kids last week. (1/8)
A lot of my thoughts have been captured by my great colleagues Jeff Gerber and @DrPaulOffit from CHOP in this short editorial published yesterday in Science. Please read this if you haven’t already: (2/8) science.org/doi/10.1126/sc…
As a society, we will eventually need to realize that all of us will be exposed to SARS-CoV-2 sometime during the next few years. The virus will continue to circulate and there is no escaping it unless you do not interact with humans. (3/8)
So our kids most likely will all be exposed to SARS-CoV-2 at some point. The question is: do you want your kids to first encounter SARS-CoV-2 in the context of a viral infection or via mRNA vaccination? (4/8)
The data are clear on this: the risk from SARS-CoV-2 infection is much higher than vaccination. For example, the risk of myocarditis is higher from infection compared to vaccination. (5/8)
For me, it is that simple. The benefit of vaccination outweighs any theoretical risk, because our kids will be infected (sooner or later) with SARS-CoV-2 if they are not vaccinated. (6/8)
The Gerber/Offit article also discusses how COVID-19 has affected social and emotional development of children. Kids need to be together, without masks, wrestling around and doing the things kids like to do. And COVID-19 vaccines are the safest way to let this happen. (7/8)
I don’t think these vaccines should be mandatory for kids at this point. But for my wife and I, eliciting immunity in our children via vaccination instead of infection makes a lot of sense. (8/8)
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Check out our new preprint: SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared to SARS-CoV-2 mRNA vaccinations 1/ medrxiv.org/content/10.110…
We found that both SARS-CoV-2 infections and mRNA vaccinations elicit antibodies that bind to the S1 and S2 regions of the SARS-CoV-2 spike. 2nd doses of vaccine primarily boost antibodies reactive to S1. 2/
Here is where it gets interesting: SARS-CoV-2 infections boost antibodies that react to the S2 region of OC43 (a related seasonal coronavirus). SARS-CoV-2 mRNA vaccines boost OC43-reactive antibodies less than infection. 3/
Our new study evaluating the relationship between common coronavirus antibodies and SARS-CoV-2 susceptibility using a cohort of >2,000 health care workers is now up at @medrxivpreprint. (1/n) medrxiv.org/content/10.110…
We collected serum samples from 2,043 health care workers during the first wave of SARS-CoV-2 activity in Philadelphia, PA. We identified a subset of health care workers who went on to become infected with SARS-CoV-2 after we collected serum samples. (2/n)
Individuals infected during the first wave of SARS-CoV-2 activity in Philadelphia mounted long lived antibody responses and we identified only one potential re-infection event during the second wave. (3/n)
1/ Our paper showing that ~20% of humans possessed non-neutralizing antibodies against SARS-CoV-2 prior to the COVID-19 pandemic was published today @CellCellPress.
There has been recent discussion of how this influenza virus mouse study that I completed as a postdoc potentially relates to current SARS-CoV-2 evolution, so I thought I would write a short thread about it. 1/ @trvrb@LauringLab
Here is the story: influenza viruses do not have a high enough error rate to simultaneously acquire mutations that block all of the different types of antibodies in most polyclonal serum...that part was figured out in 1979 when I was still in diapers....3/
Our new paper showing that some humans possessed non-neutralizing antibodies against SARS-CoV-2 prior to the COVID-19 pandemic is now up at @medrxivpreprint. Importantly, we find that these antibodies are not associated with SARS-CoV-2 protection. 1/7
In our study: 1. We did not find that kids had higher levels of pre-pandemic SARS-CoV-2 cross-reactive antibodies compared to adults. 2. We found that pre-pandemic SARS-CoV-2 cross-reactive antibodies were non-neutralizing. 3/7