First look at the only randomized trial of a booster vaccine data (Pfizer) today cdc.gov/vaccines/acip/…
95% efficacy vs symptomatic infections, consistent across all age, sex, race, ethnicity and comorbid condition subgroups
Benefit seen very early
Side by side event curves for the original Pfizer vaccine trial vs the Booster trial
You can see the curves diverge about a week earlier with a booster, ~14 vs 7 days, which aligns with much faster induction of neutralizing antibodies
Take a look at the data for people age 18- 55 in this, the only randomized trial (and N>10,000) of a booster vs placebo. Let's make believe @CDCgov that only people >age 50 "should" derive benefit vs symptomatic infections. The primary efficacy endpoint of all vaccine trials.
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Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts 1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below
2. Engaging in > 1 type of physical activity was generally correlated with better outcomes compared with 1 type (T1,2,3)
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book
President Trump takes 325 mg aspirin/day. The randomized trials tested 75-81 mg/day. His doctors recommended low-dose aspirin for heart event prevention. That recommendation is ill-founded based upon best evidence in older individuals. nejm.org/doi/full/10.10… academic.oup.com/eurheartj/arti…
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)