The synthetic biology space is all about creating new biology. This is mostly around engineering yeast or bacteria to become tiny factories. This offers a sustainable resource for rare products.
I have:
$DNA 1.38%
$TWST 1.38%
$ARMS 2.06%
$CDXS .69%
This theme makes up 5.51% of my portfolio.
$DNA is the fan favorite for this space, but it also prices in a huge amount of success already. They focus on engineering microbes to be tiny factories to product products. They also engineer microbes for commercial products like probiotics.
$TWST is the DNA company. They engineer, sequence, and create DNA for all kinds of applications including $DNA. They have multiple business segments for DNA manufacturing, sequencing, clinical development and data storage. DNA as a data storage medium sounds so Scifi.
$AMRS is another company working on turning microbes into factories to produce products. They already have several commercial products with strong sales. Their management is not the best, but they are way ahead of $DNA and at a fraction of it value.
$CDXS is the enzyme company. They design and develop enzymes for use in drug development. They make DNA and RNA polymerases. They are making the key enzyme in the new Pfizer Covid pill. They can reduce time and costs significantly with their enzymes.
This is another new space for me. Most of my positions are still very small as I try to build them into any sell offs. I have picked my top 3 I would rally around if I had to triage into a bad market.
I think I would cut $AMRS even at a small loss because it is the weakest managed of the 3 companies. Its clearly my underdog play.
I think there is a clear need in this ever growing world to find more sustainable ways to produce key components.
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This has probably been the most bubbly space in biotech the past year. I dumped all these companies back in late January and only recently started buying any of them back.
I love the genomics space, but the cart is way ahead of the horse at this point. I think many of them are now down 50% or more from their highs as human behavior always goes from bubble to bust and back again. I still don't think any of these scream cheap yet.
I snagged back a starter position in $CRSP today. I had sold 90% of my position at $175 and the rest at $130. Today, I picked up a starter .69% position at $83.33. It might have lost its innovation for now, but it is the same tech and could do everything $NTLA can.
$ARK has been loading up on $NTLA which makes me want to avoid that like the plague as its just over priced and over hyped. I can take the bet on $CRSP for a fraction of that value. They will have a strong SCD program. I have low expectations for anything else.
I am betting they will get shift gears once they have SCD commercial and get on the ball with building their next great thing. Personally, I think they should scarf up $IPSC on the cheap for their cell therapies. Or at least do a license deal.
I heard Scott Wolchko say he thought that iPSC was the cell therapy manufacturing platform of the future. I completely agree with him. All cell therapies will move into this platform. These are my leaders in the space.
I have:
$FATE 1.38%
$SANA 2.07%
$CRBU 2.76%
$IPSC 2.76%
This theme makes up 8.96% of my portfolio.
$FATE is the clear leader and pioneer in iPSC cell therapies. Their recent R&D day revealed several new edits that continue to lead the science. They have multiple programs ongoing across all blood cancers with NK cells. They will be advancing to solid tumors.
There are 2 companies working on diabetes that are using different approaches. They are $CRSP and $SANA. Personally, I think $CRSP gets all the hype, but $SANA has be better science approach. Let us look at them here.
$CRSP has a program where they engineer islet cells to produce insulin and put them into a mechanical package from Veryacyte. This is implanted into the patient to act as a fake pancreas and release insulin.
$SANA is using induced pluripotent stem cells to grow islet cells that are completely immune masked. They replace the MHC I with HLA-E which blocks killing from T can NK cells. They implant these cell right into the pancreas where they work like normal healthy islet cells.
Looking at my Targeted Protein Degrader Companies:
This is a fairly new space for me. I get that its still in early stages. I know many of the E3 ligase targets have been accidently discovered so far.
I think this space is just getting started. So much research is coming into this space for the science. There is bound to be big breakthroughs that will lead to new developments. I think this space will eventually replace the RNAi space.
It offers far more flexibility across all tissues without the worry over delivery. It offers a very clean safety profile.
This is one of my oldest investment themes. Its been the most profitable, yet most frustrating as every time I get great companies they get bought up on me and I have to start over. That why I have 5 now.
$BPMC is my oldest and longest held core position. They have amazing management and a very strong pipeline that keeps on coming up with new ideas. My worst complaint is it never crashes for me to add to it anymore. Once in a while I get lucky to add some.