Novel ketamine + psilocybin inventions?

New patent applications published:

𝔎 Celon Pharma—pulmonary administration of ketamine

𝔎 Univ Kansas—ketamine treatment for ALS

𝔎 Takeda Pharm—depression tx, after ketamine therapy

𝔎 CaaMTech—combinations of serotonergic drugs

1/6
Celon Pharma—“Ketamine Composition for Use in a Method of Treatment of Depression by Pulmonary Administration”

–inhalable dry powder ketamine compositions

–dosage regimens for their use “in a cycle of administrations of sequences of single doses”

appft.uspto.gov/netacgi/nph-Pa…

2/6
University of Kansas—“Ketamine Treatment for Amyotrophic Lateral Sclerosis”

Covers use of ketamine to:

–extend life expectancy

–increase number of days of survival

–reduce rate of deterioration of body weight

Claims all found novel & inventive

patentscope.wipo.int/search/en/deta…

3/6
Takeda Pharmaceutical—“Treatment for Depression”

Claims treating depression w TAK-653—a positive allosteric AMPA modulator

Including for patients that fail to respond to therapy w ketamine, esketamine, or HNK

Claims all found novel, none inventive

patentscope.wipo.int/search/en/deta…

4/6
CaaMTech—“Compositions and Methods Comprising a Combination of Serotonergic Drugs”

Claims compositions comprising:

–“a first purified psilocybin derivative” &

–“a first purified terpene”

appft.uspto.gov/netacgi/nph-Pa…

One of the parent apps was granted: patents.google.com/patent/US10933…

5/6
Follow psychedelics patent applications with the @PsilocybinAlpha Patent Trackers:

psilocybinalpha.com/data

6/6

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More from @calyxlaw

18 Nov
Ibogaine + MDA = “an extremely beneficial drug”?

#TBT to 1968 patents by Claudio Naranjo

“The medical preparation of the invention produces most unexpected and beneficial results, by for example alleviating fears and anxieties which may have been present in the patient”

1/12 Image
The patents claimed medical preparations of:

(1) ibogaine, iboga alkaloid extract, or total extract; plus

(2) amphetamine, MDA, TMA, tetrahydronapthylamine, or naphazoline

“The best results have been obtained with” MDA

The combination “forms an excellent medicine"

2/12 ImageImage
The ibogaine “has the effect of considerably clarifying the mind of the sick person, giving him a kind of extra-lucid vision of his ‘ego.’ It likewise excites the memory centre of the brain thus revealing memories which may go back to a period before the age of 4…”

3/12 Image
Read 12 tweets
21 Mar
New Compass Pathways patents granted?

Another US patent was granted on March 16, 2021

This is Compass’ second US patent, in same family as the first patent granted on December 31, 2019

New ‘257 patent: patft.uspto.gov/netacgi/nph-Pa…

First ‘175 patent: patft.uspto.gov/netacgi/nph-Pa…

1/7
A primary difference between the new ‘257 & the first ‘175 patent is:

– ‘175 patent claims methods “of treating drug resistant depression” by orally administering “an oral dosage form“ of the COMP360 psilocybin Polymorph A

– ‘257 patent claims the “oral dosage form” itself

2/7
Just as with the first ‘175 patent, the new ‘257 patent claims the psilocybin Polymorph A by reference to its “XRPD diffractogram”

These are the peaks displayed when the polymorph is analyzed by X-ray

Compass unsuccessfully sought claims without these XRPD limitations

3/7
Read 7 tweets
20 Mar
Who will own psilocybin for anorexia?

One of the methods claimed in Compass’ PCT application is administering “a therapeutically-effective dose of psilocybin” to a subject with anorexia

Could a claim on treating anorexia with psilocybin be granted?

1/7
Compass is listed as collaborator on an investigator-initiated study at UC San Diego, to explore the safety, tolerability, & efficacy of psilocybin-assisted therapy for anorexia

This trial was first posted on December 10, 2020

2/7

clinicaltrials.gov/ct2/show/NCT04…
Another study, sponsored by Imperial College London, will also assess the acceptability & efficacy of treating anorexia with psilocybin, & will use MRI & EEG to examine neuronal underpinnings of tx

This trial was posted earlier, on August 10, 2020

3/7

clinicaltrials.gov/ct2/show/NCT04…
Read 7 tweets
18 Feb
How much is a psilocybin patent application worth?

PharmaTher $PHRM sells psilocybin program to Revive Therapeutics $RVV

Includes full rights to PharmaTher’s psilocybin IP:

Pre-clinical work + three psilocybin provisional applications

1/4
Purchase price for PharmaTher’s psilocybin IP:

–$3 million in cash

–$4 million in securities

–up to $3 million in milestone payments

–“low single digit royalty” on future net sales

2/4
More on PharmaTher’s:

Psilocybin combination therapies:

Psilocybin in treatment of cancer:

Microneedle delivery technology, which it retains after the sale:

3/4
Read 4 tweets
17 Feb
“Emergency Off-Switch” for psychedelics?

MindMed $MMED beings study on “LSD neutralizer technology”

I.e., the 5-HT2A antagonist ketanserin: psychedelicreview.com/compound/ketan…

1/4
Patent application first announced on April 21, 2020

As @psyscireview subsequently wrote: “Few Details of the Invention Are Available”

18 months after filing, the application—& those details—will become public

~ October 2021

psychedelicreview.com/stopping-bad-l…

2/4
“LSD neutralizer technology”—is it possible, patentable, profitable?

Last year, from @D__Nickles: psymposia.com/magazine/rahn-…

Today, more insights from @mattbagg:

3/4
Read 4 tweets
16 Feb
Controlled release psilocybin + cannabinoid formulations?

New published patent application on multilayer tablets & capsules w psilocybe-derived + cannabis-derived compounds

Filed by Tassili Life Sciences, acquired last yr by Champignon Brands

patentscope.wipo.int/search/en/deta… $SHRM

1/ ImageImageImage
Application claims compositions of “psilocybe-derived agent and a cannabis-derived agent”

”formulated in multiple layers to release the psilocybin-derived agent and the cannabis-derived agent at multiple different times, dosages and/or locations in a subject during dosing”

2/ Image
Application asserts controlled release formulations of psilocybin + CBD can result in “multiple chemical-induced high/low shocks”

"useful in eliciting short or long term traumatic experience suppression in similar fashion to electroshock therapy without memory eradication”

3/ ImageImage
Read 6 tweets

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