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Matt Kaeberlein Profile picture
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23 Nov, 4 tweets, 3 min read
The best opportunity to end cancer as we know it is through targeting the biology of aging, something that is feasible today. It's time to leave behind the one-disease-at-a-time approach and embrace 21st Century Medicine #geroscience @EricLander46 @POTUS Image
@EricLander46 @POTUS Cancer was the second leading cause of death behind heart disease in the US in 1971 when the War on Cancer was declared. Cancer is still the second leading cause of death behind heart disease in 2021

jamanetwork.com/journals/jama/…
COVID-19 may end up being the 3rd leading cause of death in 2021. Death from COVID-19 is strongly age-related, just like cancer, heart disease, Alzheimer's disease, kidney disease, diabetes, ...
Please consider a #geroscience ARPA-H with the potential to actually move the needle on healthy longevity

thehill.com/opinion/health…

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More from @mkaeberlein

Matt Kaeberlein Profile picture
24 Nov
Here’s a detailed explanation with sources for my graphic illustrating potential effects of targeting aging with rapamycin in humans. This is based on a *speculative* extrapolation from mice to humans /1 Image
The graphic represents impact on life expectancy for a typical 50 year old woman from curing cancer or heart disease and comparing it to potential impact from an intervention like rapamycin that targets biological aging. Green = healthy years, red represents unhealthy years /2
The calculations for effects on life expectancy from curing cancer or heart disease come from work done by Jay Olshanksy and colleagues published in Science here:

science.org/doi/10.1126/sc…

Original graphic here:

academic.oup.com/ppar/article/2…

/3
Read 12 tweets
Matt Kaeberlein Profile picture
14 Nov
Really interesting pre-print on effects of middle-age parabiosis in mice. Definitely worth a read.

biorxiv.org/content/10.110…

I like the design here, as it parallels what we did with rapamycin in 2016. Treat from 20-23 months of age and see what happens

/1
I recommend everyone directly compare the two studies

elifesciences.org/articles/16351

We didn’t do multi-omics in our 2016 rapamycin study, but we did do some function measures and disease pathology not included here. Both studies reported lifespan extension

/2
The omics data here are compelling that there is a strong rejuvenation effect from parabiosis that persists for some period of time after the treatment ends. The actual impact on lifespan is significant but appears to be much less than 126 ppm rapamycin

/3
Read 11 tweets
Matt Kaeberlein Profile picture
11 Nov
Once-daily feeding is associated with better cognitive function and health in companion dogs @DogAgingProject biorxiv.org/content/10.110…

Preprint, not peer-reviewed yet. Correlation does not equal causation. Still, really interesting I think! @DrEmilyBray @BrianahMccoy
For those who know me, you're aware I'm not a big believer in time restricted feeding (I like to eat). And this study absolutely doesn't prove TRF is causal for the observed association with reduced disease risk in dogs. But it's intriguing, isn't it?
Lots of things we don't know. Are dogs fed once a day less likely to be obese? More active? Eat different types of diets? Will this replicate in another study population?
Read 5 tweets
Matt Kaeberlein Profile picture
18 Oct
For those who want to get beyond the pop-sci diet guru analysis, here’s a little deeper dive on this recent time restricted feeding paper in @nature

nature.com/articles/s4158…

/1
Strongly encourage you to *read the paper* and reach your own conclusions. As always, I welcome feedback if you think I got something wrong, but here’s what I took away:

/2
In fruit flies:

Time restricted feeding (TRF, 12h:12h) did not reproducibly extend lifespan

Intermittent fasting (24h:24-48h) ***shortened lifespan***

A TRF protocol (iTRF, 20h:28h) that induced autophagy at just the right time extended lifespan by ~15%

/3
Read 14 tweets
Matt Kaeberlein Profile picture
22 Sep
Drugs versus diets: Here’s some data to support my assertion that rapamycin as a pharmacological intervention for healthy aging is likely to have a better side effect profile than dietary interventions /1
Consider a hypothetical clinical trial of caloric restriction or intermittent fasting. Nearly every participant will experience multiple of the following adverse events: dyspepsia (hunger), headache, dizziness, fatigue, insomnia, poor thermoregulation, … /2
… loss of libido , constipation, diarrhea, nausea, dehydration, irritability, hypoglycemia, halitosis, dysmenorrhea … These are all well-known side effects of fasting. It seems very likely the true AE rate will approach 100% in the CR/IF group /3
Read 6 tweets
Matt Kaeberlein Profile picture
19 Sep
Genuinely surprised at the response this Tweet is getting and how many folks were unaware of the data showing caloric restriction is not universally beneficial. Many people assume these diet interventions have no risk, which is obviously false /1
I’m not trying to bash caloric restriction/intermittent fasting/time restricted feeding. The science is important, and I think many people obtain health benefits. Although those who would probably benefit most are least likely to actually practice them IMO /2
I would suggest that the risk profile for diet interventions is significantly higher than commonly appreciated, including adverse psychological effects. The impact of individual genetic and environmental context is not understood /3
Read 10 tweets

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