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NK Leb #UpdateTheVaccines 💉 Profile picture
@NickytaLeb
Dec 1, 2021 • 7 tweets • 3 min read • Read on X
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"Unhelpful" to whom? Whom is he supposed to help? He was asked a question, he gave his answer. Was the media shopping for good news?

"Stock markets fell on the news" - Who gives a shit? How is this important? Image
Point to me on this chart where the pain and suffering of shareholders is.

Two years of money raining on them crying over 2 days of the gravy train stopping at a station to refill. Image
"But muh stock market missed out on two days of 🔼. The SEC should arrest Bancel for his words." Image
"Implying none of the vaccines will work against the VIRUS" - whaat? Where did he imply that?

He said "this is not going to be good." How is this controversial? Should he have said "the more spike + RBD AA substitutions the better. Bring 'em on." ???

How is this "speculation"?? Antigenic drift is now "speculation"?
Basic immunology is speculation?
Speculation in what sense?

Some epitopes are gone. Some mAbs won't bind or neutralize. What part of this is controversial?

Let's not reinvent immunology for COVID-19 please. Image
If you are taking three shots of one of the most immunogenic vaccines in the history of vaccinology just to regain high protection against this variant, then that is an admission that there is loss of efficacy of 1 or 2 shot vaccines against this variant.

Changes on the only protein in our vaccines = loss of efficacy.
This is not "speculation" but immunology.

You know what's speculation? The stock market.
If they lost money, fuck them.

Global pandemic & I'm supposed to give a shit about 2 days of red.

See you at zero.
#CYAZ Image

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More from @NickytaLeb

NK Leb #UpdateTheVaccines 💉 Profile picture
Jan 26, 2022
Oh. Image
Citation? Image
Hmm.. weak vaccines, non-equipped health care system.

Maybe, just maybe, that's why they're doing what they're doing?
Have yous considered it?

@ZekeEmanuel @mtosterholm Image
Read 12 tweets
NK Leb #UpdateTheVaccines 💉 Profile picture
Jan 11, 2022
Some of y'all may think I'm obsessed with older tried-and-true vaccine platforms such as inactivated or attenuated virus vaccines when we have mRNA.

The problem is that most countries don't have mRNA & can't make any vaccines whatsoever, dependent on old, weak shots from China.
It's a disaster that many parts of the world will not be able to take a virus, influenza or CoV-2 strain, and inactivate it and use that as a vaccine.

This is the 2nd pandemic where low income countries see that centralized vaccine production does not work in their favor.
Spoiler alert: there will be another respiratory virus pandemic in the future.

Spoiler 2: one will be able to create a vaccine for it by inactivating the virus + adjuvant or inhaling a cold-adapted attenuated strain of it.

And low income countries will die waiting for Moderna.
Read 4 tweets
NK Leb #UpdateTheVaccines 💉 Profile picture
Jan 11, 2022
This dumb idea of "fear" causing the disruptions has to stop.

Restaurants near me that were open during the WT, Alpha & Delta waves are now (temp) closed because they have no staff. Lots of places with no temps.

This has nothing to do with "fear" of Omicron.

Folks just sick.
This has nothing to do with "overtesting" - since he have no access to any tests whatsoever (no PCRs, no rapid tests) or isolation policies (no tests = no cases = no isolation).

People are just sick in bed with "flu-like symptoms"

I don't know what to tell you.
This dumb idea that systemic T cells will prevent people from getting ill and that once all of us get these magic spike protein-targeting T cells in our blood that disruption will never happen again and that we can go back to treating this like OC43... turned out to be dumb.
Read 14 tweets
NK Leb #UpdateTheVaccines 💉 Profile picture
Jan 7, 2022
Next winter we could absolutely have COVID-19 have a "flu-like" or "less-than-flu" impact on hospitalization & mortality.

It just requires better vaccination (strain match) like the flu, preemptive vaxxing in Autumn (like the flu), vaxxing kids (like the flu)... you get my point
The ideal vaccine would be a recent, strain-matched vaccine that elicits mucosal antibodies & tissue resident B/T cells.

Every step away from that reduces VE:

1. Time since vaccination
2. Strain mismatch
3. Route (systemic vs local antibodies immune cells)

We're at 0/3 today
With 2-year-old vaccines targeting a distant relative of the circulating strain, eliciting systemic antibodies and immune cells, and this vaccine being administered 6-months to a year ago, what we are seeing is a recipe for failure.

This is a 0/3.

We don't do this for the flu.
Read 15 tweets
NK Leb #UpdateTheVaccines 💉 Profile picture
Jan 6, 2022
Just a reminder to all the "the vaccines were made to prevent severe COVID or death" losers is that moderate COVID has these symptoms, including "deep-vein thrombosis" which is very serious but still considered "moderate" for the trials.
A vaccine for a respiratory virus that does not prevent "pneumonia" is a failure. A vaccine that has does not prevent these listed symptoms is simply a failure and one must reformulate the shot to match the strain, or reconsider dose, schedule or route or the platform itself.
Fortunately for us, the vaccines in the trial prevented moderate COVID-19, as well as "symptomatic COVID-19."

Unfortunately for us, many have decided to shift goalposts & gaslight everyone, claiming that the trials were for severe COVID & death & that everything else is mild.
Read 4 tweets
NK Leb #UpdateTheVaccines 💉 Profile picture
Dec 3, 2021
This is a biphasic disease - a viral phase & an immunopathological one.

There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.

Biphasic.
The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.

Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.
Animal challenge trials, even in macaques, show only the first phase. Even unvaccinated animals only experience 7 days of a typical respiratory illness and that's it.

COVID-19 in humans is different.
Read 4 tweets

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