Oh. Citation?

Some of y'all may think I'm obsessed with older tried-and-true vaccine platforms such as inactivated or attenuated virus vaccines when we have mRNA.

The problem is that most countries don't have mRNA & can't make any vaccines whatsoever, dependent on old, weak shots from China. It's a disaster that many parts of the world will not be able to take a virus, influenza or CoV-2 strain, and inactivate it and use that as a vaccine.

This is the 2nd pandemic where low income countries see that centralized vaccine production does not work in their favor.

This dumb idea of "fear" causing the disruptions has to stop.

Restaurants near me that were open during the WT, Alpha & Delta waves are now (temp) closed because they have no staff. Lots of places with no temps.

This has nothing to do with "fear" of Omicron.

Folks just sick.

https://twitter.com/Telegraph/status/1480551852227899400

This has nothing to do with "overtesting" - since he have no access to any tests whatsoever (no PCRs, no rapid tests) or isolation policies (no tests = no cases = no isolation).

People are just sick in bed with "flu-like symptoms"

I don't know what to tell you.

Next winter we could absolutely have COVID-19 have a "flu-like" or "less-than-flu" impact on hospitalization & mortality.

It just requires better vaccination (strain match) like the flu, preemptive vaxxing in Autumn (like the flu), vaxxing kids (like the flu)... you get my point The ideal vaccine would be a recent, strain-matched vaccine that elicits mucosal antibodies & tissue resident B/T cells.

Every step away from that reduces VE:

1. Time since vaccination
2. Strain mismatch
3. Route (systemic vs local antibodies immune cells)

We're at 0/3 today

Just a reminder to all the "the vaccines were made to prevent severe COVID or death" losers is that moderate COVID has these symptoms, including "deep-vein thrombosis" which is very serious but still considered "moderate" for the trials. A vaccine for a respiratory virus that does not prevent "pneumonia" is a failure. A vaccine that has does not prevent these listed symptoms is simply a failure and one must reformulate the shot to match the strain, or reconsider dose, schedule or route or the platform itself.

This is a biphasic disease - a viral phase & an immunopathological one.

There may be 𝑠𝑜𝑚𝑒 virus in the 2nd phase & there is 𝑠𝑜𝑚𝑒 immunopathology in the 1st, & there can be rapid deterioration/cascading of 1st into 2nd, but many only experience one phase.

Biphasic. The ancestral strain of SARS-CoV-2 had a relatively mild viral phase and a possibly terrible 2nd phase. People felt mild flu-like symptoms in before rapidly deteriorating.

Subsequent variants have resulted in increased virulence, with the 1st phase being more severe, esp. Delta.

In the 1968 flu pandemic, the first batch of vaccines came out on day 66, and 5 million doses were released by day 87.

But please tell me that the mRNA vaccines are the fastest thing possible & that we should build all our future pandemic plans on the "tweeked in 2 days" mRNA. A lot of doses were produced...

The questions of transmissibility, severity, symptomology, etc. are academic and for the most part irrelevant.

This is a simple question of vaccine strain update. We do this all the time.

Boosting helps in short term, new shot next. New mAbs now.

https://twitter.com/NickytaLeb/status/1466080840362905605

The only reason we update vaccines is because of a new strain.

We don't wait for data on the severity of influenza B Yamagata or the transmissibility of this year's H3N2 to make an update, nor do we take 2+ shots of last year's flu vaccine to make up for strain mismatch.

"Unhelpful" to whom? Whom is he supposed to help? He was asked a question, he gave his answer. Was the media shopping for good news?

"Stock markets fell on the news" - Who gives a shit? How is this important?

https://twitter.com/Laurie_Garrett/status/1465705189369806848

Point to me on this chart where the pain and suffering of shareholders is.

Two years of money raining on them crying over 2 days of the gravy train stopping at a station to refill.

Good news for everyone this morning - COVID is over.

You literally never have to think about COVID ever again. More good news: Scientists on Twitter are saying that the vaccines are 99.9% effective and will remain effective for life.

The morons are at it again.

"What makes more sense"?

There are only two options. 3rd dose or no 3rd dose.

In what reality does not taking a vaccine make more sense than taking one?

None. Makes no immunological sense. What difference does it make?

The fragility, limited shelf-life and wastage of Moderna and Pfizer vaccines is a feature, not a bug.

$MRNA $PFE The West's (one sided) loyalty to the mRNA vaccines, despite a non-negligible resistance to the platform from some patients & parents, some rising contraindications & undeniably increasing prices, loyalty to the point of cancelling orders from other companies, is almost comical.

This idea that Europeans taking a booster or a fraction of American kids taking a fraction (1/3rd) of a Pfizer dose is taking vaccines away from other countries is not supported by the data.

Vaccination in the US and Europe is way down.

But people on Twitter love to punch down.

https://twitter.com/NickytaLeb/status/1459338617634107399

"Canadians are taking too many vaccines," meanwhile, no booster for vulnerable, no shots for kids.

This was said a million times, but it was not getting through.

https://twitter.com/andrew_croxford/status/1458715534770454528

https://twitter.com/NickytaLeb/status/1353971086057156608?s=20

Why SARS-CoV was more virulent than SARS-CoV-2
(part of the reason, temps, replication kinetics) and why temperature won't tell us a lot about origins or intermediary animals. biorxiv.org/content/10.110…