Gunhild Alvik Nyborg, MD, PhD, BSc Profile picture
Dec 3, 2021 9 tweets 4 min read Read on X
Norway is seeing the world’s first omicron superspreader event after a party downtown Oslo last Friday. Of 120 healthy non-symptomatic fully vaccinated individuals with a negative test, two had recently returned from South Africa and turned out to be positive, omicron. 1/
Now some 80-90 of the 120 are PCR pos, 13 of these confirmed omicron, the rest waiting for sequencing results. Some of those infected w omicron were not at the party but present at the same restaurant that evening. Not looking good re transmissibility. reuters.com/world/europe/o…
Update. Min. 60 at the party infected. Now nearing 100 cases in total that night, some not with the party but present at the same venue. Screening (likely S gene dropout PCR): about 50 suspected Omicron, the rest not yet screened. 13 confirmed Ο. nrk.no/norge/fhi_-19-… (paywall)
A total of 19 cases of Omicron verified in Norway by now, around Oslo & elsewhere. Green: No suspected cases. Yellow: Suspected cases. Red: Verified cases (see the tiny red dot on the west coast) dagbladet.no/coronavirus Image
Almost 120 people are now infected after the party downtown Oslo Nov 26. Around 70 were with the party of 120, 45-50 other guests at the same venue. Omicron suspected in all, still only verified in 13, sequencing slow, screening underway @Folkehelseinst dagbladet.no/nyheter/kan-ik…
Now also a superspreader event in Denmark - 53 Omicron cases (15 found by sequencing, 38 by s gene dropout) after a party with 150 participants
And more: In Denmark, altogether 183 cases are now confirmed, 32 by sequencing, the rest by variant PCR (this method now found to be sufficiently precise by Statens serum Institut SSI). Denmark now reports ongoing transmission among people not traveling ssi.dk/aktuelt/nyhede…
In UK, another superspreader event. Looks like we’ll see many of these with Omicron in circulation (and unfortunately, that O will spread very fast as long as we allow for such events to happen). Fortunately all cases mild here, too; positive, although way too early to conclude

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More from @GANyborg

Sep 25
SARS-CoV-2 is a systemic virus that affects the whole body, but mounting evidence shows that the brain is the organ most consistently affected in the short and long term. Letting this virus roam may prove extremely expensive for our societies.
New important study out in Nature ⬇️
For those who think cognitive effects are due to "fear",this study should help disprove that notion. Ppl who volunteered to be infected had lower cognitive scores after covid up to 1 year after(as long as study), memory and executive function most affected thelancet.com/journals/eclin…
It is well known that memory can be negatively affected in the long run after covid. Here, @ArSoraas et al report in NEJM of worse memory function in those who had been infected versus those who had not, up to 36 months after (the length of the study) nejm.org/doi/10.1056/NE…
Read 9 tweets
Sep 12
Det kom et virus som var så skadelig at hele verden stengte ned i månedsvis.

Da alle land åpnet opp, var viruset blitt «bare en forkjølelse». Plutselig var ingen lenger redde for at helsevesenet ville knele eller sykefraværet ville øke. Vi kan leve som før viruset kom. Hurra! 1/
Så øker ventetiden i helsevesenet. Mange er syke. Slutter i jobben. Sykefraværet øker. Overdødeligheten øker.
Men ingen skjønner noe som helst. Hva i alle dager er dette for noe tull? Hvorfor denne økningen?

Nei, aner ikke, jeg?
Bortsett fra at nesten alle for covid 1 gang i året eller mer nå, da. Det fikk vi ikke før.

Og ca 5% får langvarige symptomer etter covid fortsatt, selv etter omikron. Det gjorde de ikke før. Og vaksinene beskytter bare delvis.
Read 14 tweets
Dec 30, 2023
Promising results in treatment of #COVID19: Oslo team have designed a long-acting viral-entry blocking ACE2 molecule that can be administered needle-free and can block SARS-CoV-2 from getting into cells. Congrats to the team @AndersenJT and first author Sopisa Benjakul
@AndersenJT This soluble ACE2 molecule is not connected to the cell surface. When SARS-CoV-2 spike variants meet free floating ACE2, they attach to this instead of our cells
"Importantly, the dimeric ACE2-fused albumin demonstrated potent neutralization of SARS-CoV-2 immune escape variants."
@AndersenJT Here, the authors explain themselves (in Norwegian) oslo-universitetssykehus.no/om-oss/ekspert…
Read 4 tweets
Dec 19, 2023
New findings on PEM in #LongCovid in Yale study

Invasive cardiopulmonary exercise test (iCPET) measured pressure through right heart catheterizaton
on 55 patients w/post-Covid exercise intolerance.

Result: Oxygen extraction in tissues was compromised 1/
news.yale.edu/2023/12/19/stu…
This was in spite of 41 of them having no evidence of heart/lung limitations on initial tests.
openres.ersjournals.com/content/early/…
"despite the fact that the heart was pumping oxygenated blood that the lungs were providing adequate amounts of oxygen for, the extraction of oxygen by the body’s tissues was compromised in patients who had symptoms of exercise intolerance after COVID"
Peter Kahn, lead author 3/
Read 7 tweets
Jan 3, 2023
Article in @Nature w important contribution to our understanding of how COVID can trigger clotting _and_ compromise our innate immune system to make us more vulnerable to secondary infections (look around you & re-think the myth that what you see is caused by lockdowns)@Helsedir
The authors found monocytes (immune cells) from C19 patients displayed a profound defect in pathogen sensing. The defect was also found when testing for secondary rhinovirus or bacterial infections.

This may explain poor SARSCoV2 clearance & increased risk of sec. infections
In this lab study, the monocytes instead switched to a pro-thrombotic phenotype…meaning, instead of helping us fight virus and bacteria, the cells may contribute to the forming of blood clots
This comes in addition to previously shown activation of platelets that leads to clots
Read 7 tweets
Dec 28, 2022
Study finds differences in biomarkers in #longCovid
Using conventional statistics + state-of-the-art machine learning, two vascular transformation biomarkers were identified distinguishing LC patients from acutely ill C19 inpatients +healthy controls (classification accuracy 96%) A A boxplot demonstrating s...
"Our study has identified 14 significantly elevated vascular transformation biomarkers", among them two diagnostic biomarkers (ANG-1 and P-SEL).
The study also finds angiogenesis as a potential therapeutic target molmed.biomedcentral.com/articles/10.11…
(I see my quote from the article in the above comment may be misinterpreted. This was a quote taken from the paper, written by the authors and I’m not one of them! Sorry for the confusion 😟)
Read 8 tweets

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