OK time to grade the poll-
The first question is your opinion. That's fair. The evidence is that it is getting more severe, so far. We'll talk about that more in a minute.
The first question is your opinion. That's fair. The evidence is that it is getting more severe, so far. We'll talk about that more in a minute.
https://twitter.com/fitterhappierAJ/status/1468781470953181184
Nice one here. You guys are right, it gets worse for the animals with evolution. It adapts to us faster than we can adapt to it, if you get what I'm saying.
https://twitter.com/fitterhappierAJ/status/1468781727548153862
Yea, it gets worse for the mice. You know an animal it probably doesn't get worse in? Bats. They have interferon signaling to deal with this kind of nasty virus
Damn you guys are smart
Damn you guys are smart
https://twitter.com/fitterhappierAJ/status/1468782552097951745
https://twitter.com/fitterhappierAJ/status/1468783048296697857another correct response. You all are well-read. The virus evolves to bind better, it's a big fitness advantage.
The in vitro evolution is being recapitulated in real life.
As I said, it will adapt for thermodynamic favourability and hit every immunological tree branch on the way down
As I said, it will adapt for thermodynamic favourability and hit every immunological tree branch on the way down
https://twitter.com/fitterhappierAJ/status/1386107571728224256
https://twitter.com/fitterhappierAJ/status/1468784334513614849This was a tough question and requires thinking in a partially complex system
On Average, immune memory will dampen severity of a reinfection
So if you get reinfected with a more pathogenic variant it may appear less severe. But with time can decompensate
https://twitter.com/fitterhappierAJ/status/1468785190801711105Nice job
Yea, it ended up killing every young mouse it infected after 15 generations of passage
Looks like it was able to adapt to execution of its programs optimally which were incompatible with the host
Remember, cov2 has a program its trying to execute
So the question about reinfections with more virulent variants- immune memory can compensate a bit to make the reinfection less severe. However elderly can decompensate, their immune systems are not as fit. I wonder if omicron is putting kids in hospital more frequently.
All in all it seems you guys do very well with the knowledge. B+
And way better than the people with wishful thinking!
And way better than the people with wishful thinking!
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