Prof. Christina Pagel Profile picture
Dec 12, 2021 11 tweets 6 min read Read on X
THREAD on UK covid situation, Omicron and what's happening...

TLDR: Omicron increasing very fast and we are getting increasing evidence of significant ability to infect previously infected or vaxxed people.

Expect UK response to change rapidly in response. 1/10
First, UK cases are climbing, back to near January pandemic peak levels. Scotland and England are rising fastest in recent days.

In England, London is rising faster than other regions.

Cases highest in 5-14 yr olds but rising fast in 20 somethings recently... 2/10
As of end last week, people in hospital going down everywhere except England, where admissions are now going up, driven by 18-64 year olds.

Unfortunately, if cases go up sharply in next few weeks, admissions will follow. By how much is the question... 3/10
The govt, SAGE, UKHSA are all warning of a big new wave in cases driven by rise of Omicron over the coming weeks.

What we don't know is how bad the consequences will be - but it is certain that they will be worse than they would have been without Omicron. 4/10
Latest UKHSA report confirms that Omicron is doubling every 2-3 days in UK & does have a large growth advantage vs delta.

Also that vax efficacy takes a big hit - you *really need* the booster dose to protect against Omicron infection.

Full thread:
5/10
Since data for tech report, Omicron was almost 10% of cases in England by last Wednesday (now likely much higher). Also likely dominant in London by now -> already 30% cases by Weds.

Highest Omicron in 20 somethings in London. 6/10
So about 35% of UK has that third dose right now. We're giving about 400k+ doses a day which is good but we need to speed up given speed of Omicron.

Plus millions of children don't even have 1 dose let alone 3. 5-11 a priority for vax if we want to protect them next term. 7/10
The NHS is under a lot of strain already - *without* Omicron added pressure. See this thread:


Unfortunately many over 50 have waned 2nd doses & NO booster. Vax is *lowest* in London where Omicron is highest (68% 1 dose in over 12s vs 89% in England) 8/10
With the some Omicron cases now being admitted to hospital, we know that even vaccines blunt a lot of the severity of illness the sheer size of the Omicron wave could be overwhelming. Hence also the rising threat level. 9/10
Cases likely to escalate quickly in coming weeks, with potentially severe NHS consequence in Jan.

Expect response to change v rapidly too.

Best case is any vax dose stays great vs severe illness. We don't know about Long Covid.

We do need to protect kids & vulnerable. 10/10
PS quite possible that we can't test all the people wanting tests so *confirmed* cases might well not rise as fast - but because of testing capacity and not because cases aren't there to be found.

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More from @chrischirp

Jun 4
As ever, I am getting lots of pushback.
Here is a compilation of the European countries I've found with recent wastewater data. Some are going up a bit, some down a bit, some are flat, none are anywhere near previous peaks.
I can't see anything here to be panic anyone. 1/3
Image
I can't find the dashboard for Spain, but others saying it is in a wave. Perhaps it is. England has just had one - the last data we had (a couple of weeks ago from Bob Hawkins) looked as if our wave had peaked.
So, I'm not seeing reason to think things are terrible here! 2/3 Image
Yes there are new variants growing right now. They are not growing faster than JN.1 grew in December and that wave did not end up as bad as feared.
Clearly it remains true that Covid is NOT a seasonal disease (unlike Flu and RSV)
3/3
Read 5 tweets
May 8
Quick thread on the Astra Zeneca (AZ) covid vaccine since it's been in the news today.

TLDR there isn't a new "smoking gun", the AZ vax was one of first and cheapest, it saved millions of lives globally, there are better vax out there now, adapted to new variants 1/9
the AZ vaccine was one of the first approved at the end of 2020, cheaper than Pfizer, and - importantly - easier to administer in lower resource settings as it didn't require super low temperatures for storage 2/9
In most countries it was first rolled out in older adults. As it was rolled out in younger adults, a *very rare*, serious, side effect was noticed - it could cause deadly blood clots

This was spotted quickly and studied. Vax monitoring did its job. 3/9 Image
Read 11 tweets
Apr 2
A short thread on why this is not a scary chart and why all the evidence suggests that there is not much Covid around right now. 1/6 Image
the above chart is recorded covid hospital admissions / reported covid cases. It is close to 100% now *because basically only hospitals can report cases since Feb 2024*

It is to do with changes in case reporting and NOT hospital testing
2/6
In fact hospital testing has been steady since the change in testing a year ago (only symptomatic patients get tested now).

The % of people PCR tested who have Covid is 4% - there is no evidence that there are loads of symptomatic people in hospital being missed. 3/6
Image
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Read 6 tweets
Dec 21, 2023
Beyond a shadow of a doubt that England is in its biggest Covid wave for well over a year now, with latest ONS infection survey results published.

I've written about it here
1/7 tinyurl.com/ru7h3m28
Image
The UKHSA have now published their modelled estimates of what percentage of English population has Covid. And as of a week ago it's high (4.3%) and rising.

Read all about it here!
2/7
It's highest in London, South East and East & in young and middle aged adults.
The main thing is it's going up and fast, so prevalence will already by significantly higher now than it was last week. 3/7
Image
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Read 8 tweets
Nov 30, 2023
Short thread on what I said on Channel 4 news tonight.

1. Did I find Hancock a sympathetic witness?

A: I find it hard to have sympathy for someone who repeatedly claimed to have thrown protective ring around care homes, while discharging covid+ patients into them.

1/5
There were *28,000* excess deaths in care homes Apr-May 2020.

Harries thought it was "clinically reasonable" not to treat covid +ve residents in hospital. Even it was, it was NOT reasonable to return them somewhere they could infect so many other very vulnerable people. 2/5
Image
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2. Did I think scientists bear blame for not emphasising asymptomatic transmission?

A: No, because they very clearly did advise there could be asymptomic transmission before March 2020 - sources in next tweet. 3/5
Read 5 tweets
Nov 30, 2023
Hancock: "there was no way we could allow the NHS to become overwhelmed"

Except, the NHS WAS overwhelmed

Here is what NHS staff said about that time - Pls read whole 🧵
"Heartbreaking"
"Horrific"
"It broke my soul"
"We cried, we came home exhausted. We were overwhelmed"

1/16
"Overnight we were told that all “safe working rules” were gone. There was no choice, we were forced to do it"

"It felt like a death sentence. It felt out of control"

"We were put on wards with no senior support, sometimes makeshift ... with little of the right equipment"

2/16
"Terrifying. A huge sense of duty ... but also terror. We were unprepared & ovt clearly had no plan"

"We had patients on wards on 19 litres of oxygen - this would never happen under normal circumstances - they’d have come to Intensive Care but we didn’t have the space"

3/16
Read 17 tweets

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