We have to be thinking of tests used for public health with population metrics:
If delay is 3 days to get results:
Then for every 2 infectious ppl detected, the wait time alone (6 person days of the person spreading while waiting) is equal to missing 1 full infection
2/
So the EFFECTIVE SENSITIVITY of a 3 day delayed PCR approaches only 50-60%
You miss ~half of the infectious days - even if you ultimately diagnose nearly everyone. But it is the infectious days averted that is important for public health. Not identifying ppl afterwards
3/
And if ppl are quarantining while waiting (most don’t) then if wait time is 3 days, then
4 negatives = 12 person days unnecessarily in quarantine = 1 false positive result for every 4 negatives (in terms of unnecessary person-time quarantine)
Unacceptable
4/
When testing for Public Health
The 3 most important metrics to consider are
SPEED
FREQUENCY
ACCESS
FDA considers none of these 3
Yet these are almost always more important than the molecular sensitivity (specificity matters but can be easily boosted w fast confirmation)
5/
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My goal is to say simply -
Focus on the science and the data and what we know of biology. Then message and create policy off that.
Yes we want everyone vax’d. But really we want everyone protected. With >50% of Americans exposed/infected… we should at least consider this…
2:
We absolutely do not want ppl to intentionally go out and get infected. But we also can’t reverse time. We know a majority of Americans have been infected. Given that protection is derived from infection - assuming you do OK through it - we should leverage that, not ignore it
I’ve been working w vax hesitant and anti vax groups for years BEFORE the pandemic
Blame and Shame has never, ever, been the appropriate tactic to change minds. This is a pandemic of a virus
Ppl are either scared or misinformed,
First thing is GAINING TRUST
1/
Shaming and blaming does the exact opposite of gaining trust.
We cannot overlook that we had and still have leaders who have confused the shit out of ppl. Scared them of vaccines. Told them over and over that the virus is not bad.
In summer, the northeast & US government called the pandemic a “pandemic of the unvaccinated” and blamed transmission in southeast on politics & vaccine hesitancy
As we see cases swamp the Northeast, I hope we remember that this is a pandemic of a virus
I feel like “we” are very quick to look for scapegoats as the rhetoric and force of scientists and politicians has become increasingly heated around vaccines.
Vaccines work extremely well, yes. But this remains a pandemic of a virus. The core problem is the virus.
Again - I am 1000% for vaccines & want every one to be vaccinated
I'm not in favor of blaming by our federal government rather than trying to better understand underlying / root cause of vaccine hesitancy and work towards that.
Additionally (and for a different thread) it is clear that concerns Of having a narrow vaccine as our primary intervention is going to come up short. It’s always been the case, despite media, that infections (should you do ok through them) would offer robust immunity.
2/
I’ve said many times we should be considering vaccines that are not solely a Wuhan strain spike only but perhaps boost, for example, w live attenuated or some other form of vax that offers immune system a broader education
As I said last year, Narrow vaccines can be shortsighted
If using rapid tests this holiday season and asking ppl to test before a gathering… or any time…
Suggest they be done before leaving the house, or in the car, etc. Someplace >55 F
Also, if your counter or table or wherever you are letting them sit for the 15 minutes is cold (like a granite countertop) - place it on top of the box or literally any other surface that’s not cold (wood table, book, etc)
Also - this is not the same as storage. If they are sitting inside the box not being used yet, then store ideally in a slightly cooler location - but don’t let them freeze - it can potentially impact their chemistry.