Thread by @eugyppius1

It has long been obvious, that the lack of interest in developing variant-specific vaxx reflects a pervasive acceptance of the phenomenon of Original Antigenic Sin among vaxx developers.
wsj.com/articles/covid…

There’s always a minority of observers who treat my posts on Original Antigenic Sin like it’s some crackpot theory of human immunity, whereas in fact there’s an extensive literature behind it and it’s widely (if often silently) acknowledged among vaxx developers.

Filling in the blanks, I think there was an informal confidence that, because SARS-2 had been leaked, spike was already optimised. Mutations could only take it downhill. They gambled on vaxxing everyone against what they thought was the optimal form of the protein …

… and then got pwned when the VaRiANtZ emerged in late fall 2020, as via mechanisms unknown the SARS-2 spike achieved optimisations that GoF hadn’t been able to confer up on it.