Eric Feigl-Ding Profile picture
Dec 15, 2021 13 tweets 7 min read Read on X
💡New VACCINE RANKING of ability to neutralize #Omicron—Moderna appears to be the strongest against Omicron in this study, but still big drop. Pfizer next best (but we know infection efficacy is 30-34%), AstraZeneca & Sinopharm poor. J&J & Sputnik = zero.🧵biorxiv.org/content/10.110… Image
2) Natural infection immunity is on the left … “convalescent” = practically no neutralization against #Omicron in this study by itself without vaccine. Image
3) Meanwhile for SinoVac —one of the world’s most widely used vaccines, doesn’t provide sufficient antibodies to neutralize the #omicron variant, said 🇭🇰 researchers. But a 3rd shot booster seemed up help. bloomberg.com/news/articles/…
4) The other recent large South Africa 🇿🇦 study reports 2 shots of Pfizer offered 33% VE against symptomatic infection; and 70% against hospitalization (much lower than the 90s prior). We need boosters.
5) in an AT study of neutralization, they also found 2 shots of AstraZeneca was pretty weak. But also found Moderna weak—but in their population, Moderna folks had a 4 month gap between shots. But mixing AZ+Pfizer seems half decent. Past infection alone little help! (Lower left)
6) This above Austrian neutralization study matches the drop in VE seen in the UK — where 2x shots of Oxford-AstraZeneca has little benefit without a booster, and 2 shots of Pfizer slightly better but still only in the low to mid 30% VE without a booster.
7) But a 3rd shot (Pfizer booster) after 2 shots of AZ puts one back up to 71.4% VE against symptomatic #Omicron disease after 2 weeks after 3rd shot. This is good news at least. #GetBoosted ImageImage
8) With 2 shots of Pfizer, the VE starts at 88% between 2-9 weeks after the 2nd shot. Good, but it quickly drops to 48.5% by weeks 10-14 after 2 shots. Then drops and to 31% by 15-19 weeks. Then it hovers at 36.6% at 20-24 weeks. Then 34.2% at 25+ weeks. But 75.5% with booster!👀 ImageImage
9) The top study also compared the key monoclonal antibody drugs (the major drug ones have a name on the left) — several of them have little to no detectable effects against #Omicron. This is bad. Image
10) Which are the monoclonal antibody drugs in trouble against #Omicron? These:
11) The Sputnik V vaccine has entered the chat… their research institute Gamaleya Center has put out a statement saying the study reported above was “not representative” and they will have new results in a few days.
12) it’s now clear that #Omicron is spreading so fast because it both **evasive** as well as highly contagious — new study finds the virus replicates **70x faster in one’s windpipe** than the original Wuhan virus. 👇
13) the airborne nature of the coronavirus cannot be overlooked— in fact— stopping airborne transmission is just as important and vaccinating people. And ventilation and air disinfection could even be more effective - because it is agnostic to vaccine willingness / politics!

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More from @DrEricDing

May 2
Incredibly frustrating that the @USDA again failed to include basic information about H5N1 genetic sequences from cows. All data had dates and locations scrubbed out—only saying “USA” & “2024”, which is useless for scientists to analyze for mutation rates.
statnews.com/2024/05/02/bir…
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2) The fact that basic information — called metadata — isn’t being shared about the samples “hinders our efforts a lot,” said Gytis Dudas, a senior researcher in genomic epidemiology and metagenomics. Dudas is working with a group of U.S. and international researchers to try to make sense of what the genetic sequences say about the H5N1 outbreak in cows.
3) A number of scientists have openly questioned whether the USDA is deliberately withholding these data, or even removing more specific information. 🔥
Read 5 tweets
Apr 27
⚠️CDC WARNING FOR ALL VETERINARIANS, POULTRY, DAIRY & CATTLE FARMWORKERS, SLAUGHTERHOUSE WORKERS—New CDC guidelines now released to use PPE for high risk bird flu exposure occupations (all recommended):

📌N95 respirators
📌Goggles 🥽 or face shield 🛡️
📌Coveralls or fluid-resistant aprons
📌Head covering
📌Rubber boots with sealed seams
📌Gloves

Furthermore:
📍Designated areas for changing PPEs
📍Do not eat, drink, chew gum, chew tobacco, smoke, vape, or use the bathroom while wearing above PPE
📍Shower after work shift
📍(see full list for more details).

Glad the @CDCgov is taking this seriously. You should too. And please don’t drink raw milk 🥛! #AvianFlu #BirdFlu #H5N1
cdc.gov/flu/avianflu/h…Image
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Don’t do raw milk 🥛 please, for the love of god. I know there are many raw milk enthusiasts out there. But just take a pause until this is over? Don’t try to be a macho man about this.
3) try to drink either vegan milks like oat or soy or almond milk, or ultra pasteurized milk.
Read 9 tweets
Apr 27
Seriously. Raw milk drinkers… don’t do it. We scientists are pretty damn sure there will be some degree of active virus inside raw milk. Cats have been infected on farms—via likely raw milk. And all 6 cats with bird flu have died of rapid neurological declines, says CDC.
Raw milk drinkers… 1% of all milk being non pasteurized worries me. Too much virus to be potentially circulating.
3) I’m sticking with either vegan types of milk, or ultra pasteurized just to be safe.
Read 6 tweets
Apr 26
⚠️Bad signal—CDC confirming—“cats having neurologic symptoms, rapid decline, and death” from H5N1 #birdflu. 3 more cases in cats 🐈 on dairy farms… now 6 total. ➡️The prior 3 bird flu positive cats? All dead now. Likely more. This is mammalian adaptation.
bnonews.com/index.php/2024…
Image
2) I suspect cats are drinking milk from the dairy cows on the dairy farms. This is why we shouldn’t drink raw milk 🥛 currently. Even pasteurized milk, some scientists are unsure of because of lack of safety data. See thread 🧵 below.
3) Not just cats — certain dog breeds (like beagles are highly susceptible to H5N1 avian flu too. And such dogs can facilitate their adaptation towards humans eventually (since more dogs are around people than dairy cows).

pubmed.ncbi.nlm.nih.gov/20580396/
Image
Read 10 tweets
Apr 25
📍Let this sink in—a world leading virologist @RickABright who has studied H5N1 bird flu says he is pausing all his milk consumption until he sees proof from both FDA & USDA that pasteurized milk is safe to drink. Pausing milk because of his concern over lack of transparent data.
Why are scientists pausing milk intake? Because there still isn’t enough data on safety of pasteurized milk. There has been data on other viruses in the past that survive pasteurization. See detailed thread 🧵 below.
3) also avoid raw and undercooked eggs for now just to be safe…
Read 15 tweets
Apr 24
Testing conducted by the FDA on pasteurized commercially purchased milk has found genetic evidence of the H5N1 bird flu virus. ➡️But the testing, done by PCR cannot distinguish between live virus or fragments of viruses that could have been killed by the pasteurization process.

The FDA said it has been trying to see if it could grow virus from milk found to contain evidence of H5N1, which is the gold standard test to see if there is viable virus in a product. 📌The FDA *does NOT explicitly say FDA laboratories were unable to find live virus in the milk samples, but nevertheless it does state that its belief that commercial, pasteurized milk is safe to consume has not been altered by these findings.

(Sound familiar? Just like blanket assuming a virus “isn’t airborne”, “cannot transmit without symptoms”, “no human to human transmission” errors during COVID). That said, I will am hopeful that no live virus will be found in confirmation. But let’s be precautious.
statnews.com/2024/04/23/h5n…Image
2) PPE and safety googles or face shield recommended for dairy farmers and anyone handling raw milk 🥛. Also they warn about poor fitting respirators for children (who may work near dairy— like I used to help on a dairy farm as a kid in rural Pa). Image
3) people working with cattle 🐄 should also “avoid eating drinking smoking chewing gum in contaminated areas or touching eyes.” And people exposed should wear PPE should be monitored for symptoms for 10 days. Image
Read 10 tweets

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