Any writer who claims 'UK models always overestimate COVID numbers' is either lazy or trying to mislead their readers. A few illustrations... 1/
A surprisingly under-reported example is early UK scenario models (although @anthonybmasters & @d_spiegel correctly flag it in 'Covid by Numbers'). Some point estimates from initial 'recurrent lockdown' scenarios were lower than what actually occurred:
2/
Then there’s the July 2020 report from @acmedsci, which used Imperial modelling. It was designed to be a plausible worst case scenario, not a forecast, but ended up strikingly close to reality (with Alpha increasing risk & vaccines decreasing it): 3/

Estimates of increased transmissibility of Alpha and Delta also came from modelling, which implied they'd become dominant across Europe. Despite a lot of criticism at the time (and lots of abusive messages in my inbox), this is exactly what happened: 3/
Also, July 2021 reopening scenarios. There's been much focus on specific epidemic curves (often stripping away uncertainty intervals & full range of scenarios), but good faith readers can compare scenarios with subsequent known values for mobility, vaccine effectiveness etc...4/
E.g. Below scenarios from LSHTM model, with range of assumptions about mobility and vaccine effectiveness (gov.uk/government/pub…). In reality there have been around 16k COVID deaths in England since 1st July, and around 120k admissions. 5/
It’s important to have critiques of modelling (e.g. what's Q being addressed? What unknowns make most difference to results?) But if an article suggests models always cherry pick overly high numbers, bear in mind it's the writer who is really doing the cherry picking. 6/6

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More from @AdamJKucharski

22 Dec
Unfortunately, this oft-quoted Spectator tracker of COVID 'scenarios vs outcomes' seems at best muddled and at worst actively misleading. A thread on some weird comparisons - and how to do better critiques...
data.spectator.co.uk/category/sage-… 1/
First plot is comparison of scenarios for increased R values with later data. Crucially, these weren't predictions about what R would be (R estimate that week was 0.9-1.1, so pretty flat epidemic). Rather, report showed what could happen if R increased beyond current range... 2/ Image
Not sure why they cut out the R=2 scenario from original plot (which would've made it obvious these were illustrative - assets.publishing.service.gov.uk/government/upl…). TBF SPI-M plot could have included horizontal line to illustrate what R=1 looks like, but don't need a model to draw a flat line... 3/ Image
Read 21 tweets
27 Nov
A lot of Twitter currently seems to be a split of either fatalism about Omicron variant, or advocacy for retweetable-but-flimsy measures that are unlikely to suppress transmission of a genuine threat. Discourse needs to be much better - for this situation and future pandemics. 1/
This piece is one of the few I’ve seen IMO asking the right sorts of questions. If we need to update vaccines (still a big if), how much time do we need to buy? What will the scientific, logistic and regulatory challenges be?
thetimes.co.uk/article/how-lo…
2/
And, of course, if we need to update vaccines, how do we get them to places most affected in equitable way? 3/

Read 4 tweets
26 Nov
Reminder that reactive travel bans typically slow but don’t stop importations. If new B.1.1.529 variant genuinely more transmissible/can evade immunity to some extent, reasonable to assume already undetected cases in other regions... 1/
For example, Israel had multi-pronged efforts to keep Delta out (which bought time for more vaccination), but even so the rise was only a couple of months behind UK: 2/
Countries should therefore have plan to deal with local outbreak. Recent reintroduction of control measures across Europe may be helpful coincidence (in short term at least), reducing contacts & making it harder for imported cases to establish... 3/
Read 7 tweets
25 Nov
Quick collation of threads worth reading if you want to know more about the new B.1.1.529 variant identified in South Africa... 1/
Perspective from frontline of analysis: 2/

Summary of South Africa MOH briefing earlier: 3/

Read 6 tweets
23 Nov
A few thoughts on current COVID situation in Europe… 1/
Any proposal to reduce COVID transmission that doesn’t now have vaccines and rapid tests front-and-centre is not a proposal that’s had much thought go into it. Booster data looks very good - roll-out of these is likely to play a large part in how well countries do over winter. 2/
I think any country reintroducing lockdown-type measures needs to outline very clear criteria for lifting them. What’s the exit strategy? When will these disruptive last-ditch measures finally be off the table? 3/
Read 8 tweets
22 Sep
A question I often see: if COVID transmission continues, when will it reach a stable ‘endemic’ state? One way to look at it: the dynamics of endemic infections are typically driven by emergence of new susceptibility. A few thoughts… 1/
Many endemic infections continue to circulate because new susceptibility is gradually accumulated as unexposed children are born: 2/

For other pathogens (like seasonal coronaviruses) new susceptibility can also come from waning of existing immunity, or antigenic evolution of the virus - which has the effect of making previously immune people susceptible to infection again: 3/

Read 4 tweets

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