Back in Jan-Feb when I said mRNA vaccines were 3-dose vaccines and we’ll need boosters in 6-12 months, almost everyone pushed back, including many in the Fed Govt, FDA CDC advisory committees. I did think 3rd dose would last longer (“3 and done” I said) but the data are the data
And the data from UK and Israel showing virus neutralizing antibodies vs omicron not holding up after a booster. To be sure 3 doses still holding up well vs most serious infections but vs symptomatic illness not great, especially a couple of months after the booster.
Hence my recommendation for a second booster for HCWs. Not advocating yet for other populations although I see Israel 🇮🇱 Govt has extended to both HCWs and >60. Both US and Israel appear to support 2nd boosters for immunocompromised
Look I’m not happy mRNA is less durable than we hoped vs omicron, but it will still save your life. I’ve worked on coronavirus vaccines for a decade, I know their performance features + like all vaccines their strengths/weaknesses. Maybe our vaccine will hold up better? We’ll see
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