Sometimes wish journalist reports would provide citations for statements made. Example:

"A new British report shows that booster doses are less effective against Omicron than previous variants, and their effectiveness wears off faster — within 10 weeks."

nytimes.com/2021/12/23/wor…
The claim comes from this technical briefing which doesn't sound that terrifying. Just a 15-25% reduction in vaccine effectiveness after 10 weeks. Yes, it's faster for Omicron than for Delta. But it's not like the boosters don't work after 10 weeks.
assets.publishing.service.gov.uk/government/upl…
Bit further down in the doc (page 25), it says:

Pfizer 2 shots + Pfizer booster = ~70% vaccine effectiveness against symptoms; dropping to 45% after 10+ weeks

Pfizer 2 shots + Moderna booster = ~70-75% vaccine effectiveness even up to 9 weeks later
Same document says "It will be a few weeks before effectiveness against severe disease with Omicron can be estimated" but assumes vaccines will still be protective against Omicron since there was "no diminution of protection" against hospitalizations involving Delta vs Alpha.
Would've been helpful if the data (symptom types, no. of days w symptoms) were provided so we can see if being vaccinated reduces the severity of non-hospitalization-level symptoms.

Might not be bad if people still develop symptoms so they don't go out and spread it to others.

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More from @Ayjchan

29 Dec
What we know from recent papers + data deposited into NCBI by the Wuhan Institute of Virology / EcoHealth Alliance just before the pandemic is that by 2016 they were actively sampling bat viruses in Yunnan and North Laos, where the closest relatives to SARS-CoV-2 have been found.
There are 2 things we don't know.

1. What other viruses and locations were sampled between 2016-start of pandemic. Their collaborators across 7 SE Asia countries, including Laos, wouldn't tell @theintercept @fastlerner

theintercept.com/2021/12/28/cov…
Although much of this work was funded by US sources such as USAID (PREDICT) and NIH/NIAID.

EcoHealth even told NIH in 2016 that they were going to transfer pathogen samples from the wildlife trade directly from 7 SE Asia countries to Wuhan.
Read 20 tweets
28 Dec
I'd like to see this problem of inequitable credit and technology sharing solved.

If updated vaccines/therapeutics/diagnostics are developed, these should be sent first to places that reported the new variant(s) used in the update.

There should be a new credit sharing system.
In a pandemic when novel SARS-CoV-2 sequences can rapidly translate into updated vaccines, diagnostics & therapeutics, why don't prominent journals guarantee a "Resource" paper for the researchers who are the first to share the sequence of a new variant of interest/concern?
This way, data sharing is highly incentivized and accelerated.

Both the sequence contributors and the journal are rewarded due to hundreds or thousands of citations of the Resource paper.
Read 4 tweets
28 Dec
Another key piece on risks of lab-based outbreaks by @fastlerner @theintercept

"it is not at all clear that tracking down virus-infected wildlife in remote locations, to which the U.S. devotes.. substantial [$].. helped us prepare for our current crisis"
theintercept.com/2021/12/28/cov…
"Virtually every part of the work of outbreak prediction can result in an accidental infection. Even with the best of intentions, scientists can serve as vectors for the viruses they hunt — and as a result their work may put everyone else’s lives on the line along with their own"
Dennis Carroll, who designed and led Predict:
“It’s fool’s gold to think that you’re going to predict which is the next virus. But you can begin forecasting where that emergence is most likely to occur... I probably never should have named Predict ‘Predict’”
Read 12 tweets
28 Dec
"The number of hospitalisations related to the Omicron variant is climbing rapidly across the UK, with a jump of 67 per cent in London alone."
cityam.com/omicron-hospit…
🇨🇦 "Linda Silas, head of the Canadian Federation of Nurses Unions, said the “big bump” is usually seen two weeks after exposure to the virus, and expressed worries that holiday gatherings could lead to hospitals becoming overwhelmed with new cases."
globalnews.ca/news/8475226/c…
🇦🇺 "biggest daily surge in infections.. the authorities refrained from imposing new restrictions saying hospitalisation rates remained low"

"Sydney testing clinic.. wrongly told 400 COVID-positive people they were negative in the days before Christmas"
reuters.com/business/healt…
Read 5 tweets
27 Dec
Omicron (orange line; BA.1) dominating in every continent.

Visualized on the homepage of covidcg.org @covidcg
@CovidCg New % of sequences shared by each country each week that are Omicron.

Visualized using the Compare Locations feature on covidcg.org
@CovidCg For US states, new % of sequences shared by each state each week that are Omicron.

Visualized using the Compare Locations feature on covidcg.org
Read 6 tweets
24 Dec
Important perspective by @michaelzlin on the new Merck pill that works by mutagenizing SARS-CoV-2:

"The FDA and Merck have essentially engaged the public in a gamble.. They are betting.. there won’t be even one case of a lucky hit that creates a more capable or evasive virus."
@michaelzlin His free-to-read thread providing more detail is here:
I have not heard a single scientist friend or colleague say they have good feelings about this Merck pill.

I also worry that it will be given to people for whom there may be adverse effects, e.g., women who don't know they're pregnant, couples who are conceiving.
Read 6 tweets

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