"it is not at all clear that tracking down virus-infected wildlife in remote locations, to which the U.S. devotes.. substantial [$].. helped us prepare for our current crisis" theintercept.com/2021/12/28/cov…
"Virtually every part of the work of outbreak prediction can result in an accidental infection. Even with the best of intentions, scientists can serve as vectors for the viruses they hunt — and as a result their work may put everyone else’s lives on the line along with their own"
Dennis Carroll, who designed and led Predict:
“It’s fool’s gold to think that you’re going to predict which is the next virus. But you can begin forecasting where that emergence is most likely to occur... I probably never should have named Predict ‘Predict’”
Edward Holmes et al wrote in @Nature in 2018, "dubbed the idea that scientists could prevent the next pandemic by genetically characterizing all viruses the “forecasting fallacy” and urged his fellow researchers to focus on more cost-effective approaches to mitigate disease"
On Wuhan Institute of Virology:
“Despite the fact that they had been conducting intensive surveillance & characterization of SARS-like coronaviruses, they failed to identify the SARS-like coronavirus, SARS-CoV-2, that jumped into humans right where they were doing their studies”
Jesse Bloom:
"if it is actually the next pandemic virus and you’re collecting it and bringing it back to a lab and studying it, there’s some risk that if something goes wrong, it could cause a pandemic" theintercept.com/2021/12/28/cov…
“There was a concerted effort to actually take some of these samples from Vietnam, Myanmar, Cambodia, Laos and bring them to the Wuhan Institute of Virology,” said @gdemaneuf “That’s a big change because now we have a direct link between Laos and the Wuhan Institute of Virology.”
@gdemaneuf "The Intercept reached out to 6 of the scientists EcoHealth Alliance listed as viral sampling collaborators in its letter to the NIH, including.. [their] contact in Laos"
Only the contact in Cambodia replied, saying they did not have info.
"the NIAID’s funding for virus research, which ballooned because of bioterrorism fears, has inadvertently resulted in what could be a bioterror arsenal if it fell into the wrong hands"
Filippa Lentzos:
“It’s not clear how NIH is doing risk assessment or whether they’re completely outsourcing it to the grantees.”
@theintercept: Post-pandemic “[NIH] was still struggling to understand what biosafety protocols had been in place at the Wuhan Institute of Virology”
@FilippaLentzos in @theintercept
"The pressure to transgress those [safety] norms is built into the profession of science. “You have to push the envelope. That’s what gets recognition, not just peer recognition, but that’s what gets funding. That’s what gets publication.”"
What we know from recent papers + data deposited into NCBI by the Wuhan Institute of Virology / EcoHealth Alliance just before the pandemic is that by 2016 they were actively sampling bat viruses in Yunnan and North Laos, where the closest relatives to SARS-CoV-2 have been found.
1. What other viruses and locations were sampled between 2016-start of pandemic. Their collaborators across 7 SE Asia countries, including Laos, wouldn't tell @theintercept@fastlerner
In a pandemic when novel SARS-CoV-2 sequences can rapidly translate into updated vaccines, diagnostics & therapeutics, why don't prominent journals guarantee a "Resource" paper for the researchers who are the first to share the sequence of a new variant of interest/concern?
This way, data sharing is highly incentivized and accelerated.
Both the sequence contributors and the journal are rewarded due to hundreds or thousands of citations of the Resource paper.
"The number of hospitalisations related to the Omicron variant is climbing rapidly across the UK, with a jump of 67 per cent in London alone." cityam.com/omicron-hospit…
🇨🇦 "Linda Silas, head of the Canadian Federation of Nurses Unions, said the “big bump” is usually seen two weeks after exposure to the virus, and expressed worries that holiday gatherings could lead to hospitals becoming overwhelmed with new cases." globalnews.ca/news/8475226/c…
🇦🇺 "biggest daily surge in infections.. the authorities refrained from imposing new restrictions saying hospitalisation rates remained low"
"Sydney testing clinic.. wrongly told 400 COVID-positive people they were negative in the days before Christmas" reuters.com/business/healt…
Sometimes wish journalist reports would provide citations for statements made. Example:
"A new British report shows that booster doses are less effective against Omicron than previous variants, and their effectiveness wears off faster — within 10 weeks."
The claim comes from this technical briefing which doesn't sound that terrifying. Just a 15-25% reduction in vaccine effectiveness after 10 weeks. Yes, it's faster for Omicron than for Delta. But it's not like the boosters don't work after 10 weeks. assets.publishing.service.gov.uk/government/upl…
Bit further down in the doc (page 25), it says:
Pfizer 2 shots + Pfizer booster = ~70% vaccine effectiveness against symptoms; dropping to 45% after 10+ weeks
Pfizer 2 shots + Moderna booster = ~70-75% vaccine effectiveness even up to 9 weeks later
Important perspective by @michaelzlin on the new Merck pill that works by mutagenizing SARS-CoV-2:
"The FDA and Merck have essentially engaged the public in a gamble.. They are betting.. there won’t be even one case of a lucky hit that creates a more capable or evasive virus."
I have not heard a single scientist friend or colleague say they have good feelings about this Merck pill.
I also worry that it will be given to people for whom there may be adverse effects, e.g., women who don't know they're pregnant, couples who are conceiving.