CDC's estimate for the prevalence of Omicron last week dropped significantly from 73.2% w/ a 95% prediction interval of 34-94.9% down to 22.5% w/ a 95% prediction interval of 15.4-31.5%.

12/25 estimate is 58.6% with a 95% prediction interval of 41.5-74%.
Statistics are hard and I know health media can do a better job communicating the uncertainty of these projections.

Would love to get some perspective from @cmyeaton @mlipsitch on how they think about this.
CDC just responded to my initial inquiry:

"There was a wide predictive interval posted in last week’s chart, in part because of the speed at which Omicron was increasing. We had more data come in from that timeframe and there was a reduced proportion of Omicron."
I've followed up with a few questions, I wonder if the preference for sequencing s-gene dropouts (labs were looking for the first cases of Omicron in the U.S.) made the Nowcast modeling more challenging initially.
CDC didn't respond to my follow up questions, but here's the story: politico.com/news/2021/12/2…

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More from @davidalim

29 Dec
Really interesting and telling interview by @chrislhayes with Anthony Fauci tonight on CDC's isolation guidance.

Gives insight into what CDC and top admin health officials were thinking.

Really blunt discussion of trade offs to keep society running during upcoming weeks.

🧵:
Fauci: "So many people — now and likely in the next few weeks — who will be infected by this wave of infections that we're getting with Omicron ... that might have a negative impact on our ability to maintain the structure of society."
@chrislhayes: "You are talking about a policy judgment in a context of tradeoffs between different consequences."

Contrasts stopping spread of Covid-19 vs having a water treatment facility have its technicians all out sick for 10 days.

Fauci nods yes and responds: "Correct."
Read 11 tweets
8 Mar 20
Messaging on #COVID19 from present and former government officials is drastically changing today - but if you've been paying attention, it is consistent with what @DrNancyM_CDC said two weeks ago.

"Disruption to everyday life might be severe," she warned. (1/n)
The World Health Organization has been slow to call #COVID19 a pandemic. But that is where we are today, experts tell me.

I've struggled immensely to determine what is appropriate language to use and which stories are responsible to write. I joined @POLITICO in January. (2/n)
This morning, President Donald Trump's former FDA Commissioner @ScottGottliebMD laid out in stark terms how quickly everyday life will change in the USA.

Locking down cities. Preemptive bailouts of small businesses. The potential for an overrun health system. (3/n)
Read 12 tweets
29 Feb 20
NEW: @US_FDA issues immediate guidance to allow high-complexity labs to create their own #COVID19 tests, which @POLITICO reported yesterday.

Allow labs to immediately use tests BEFORE the agency grants an emergency use authorization.

Document here: fda.gov/media/135659/d…
@US_FDA @politico “We believe this action will support laboratories across the country working on this urgent public health situation," medical device chief regulator Jeff Shuren said.

Labs still must validate tests prior to use - and a disclaimer that FDA review is pending must be given.
@US_FDA @politico FDA wants labs to submit a full EUA request within 15 business days that an assay is successfully validated.

Ultimately - this move to expand #COVID19 testing comes after weeks of difficulty by public health labs to validate CDC's diagnostic:
politico.com/news/2020/02/2…
Read 6 tweets

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