Recent unsuccessful #RCT: STOP-IgA (immunosuppression+supportive care isn’t superior to supportive care alone) & TESTING (corticosteroids reduce risk of #ESRD but cause serious infections) were covered by @NephJC: nephjc.com/iga-nephropath…
and nephjc.com/news/2017/8/28… … (2/16)
Question for the #NephTwitter: What percentage of patients with IgA nephropathy develop #ESKD by 10 years? (3/16)
1/ #Tweetorial#NephJC#Hypernatremia Reviews and guidelines say to correct hypernatremia in adults by no more than 10 mmol/L per day. This is based on little hard data, has little support in literature and may be harmful nejm.org/doi/full/10.10…
2/ What rate do you target for the correction of chronic (>48 hours or present on admission) hypernatremia #NephJC
3/ The rapid lowering of serum sodium will lower the tonicity of the extracellular compartment. Water will then be osmotically drawn into relatively hypertonic intracellular compartment. This can cause cerebral edema and increased intracranial pressure. #NephJC