Dear Journalists,
There is a story here π Phil Krause and Marion Gruber #2  at FDA vax have resigned over white house pressure on boosters.
Now FDA pushes this without advisory committee & with uncertain safety in boys.
The fact nearly no one would say that the AAP and CDC were off their rocker to defy the World Health Organization and UNICEF to push this foolish recommendation down to 2 will be a shameful blemish on their reputations, I doubt they will recover in next 25 yrs.
Data from Spain, of regression discontinuity design, showed it did not work months ago. Sadly CDC pushed embarrassingly flawed studies in MMWR to defend their failed policy instead.
Our new paper is now out in European Journal of Cancer
We analyze 55 cancer drugs that target genomic abnormalities & assess the evidence
Only 24% reported an improvement in survival π
A seductive mechanism of action apparently means low levels of evidence
[thread]
Modern oncology has several classes of drugs
Cytotoxic drugs
Checkpoint inhibitors
CAR-T therapies
General targeted drugs &
Drugs that target specific cancer genomic abnormalities
(Genome drugs!)
Genome drugs get outsized attention; Previously we found that (best case scenario) 13% of US cancer patients were eligible for these drugs; leaving 87% not eligible