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Vinay Prasad, MD MPH 🎙️📷 Profile picture
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2 Jan, 5 tweets, 2 min read
Rates of myopericarditis s/p D2 COVID19 vax by @KPNorthwest
1 in 2700 Boys 12-17
1 in 1860 for Men 18-24

USA must suspend Moderna Men <40
Must reconsider or space dose 2
Needs VRBAC & ACIP prior to boosting 12-15
Interview Resigned FDA directors

medrxiv.org/content/10.110…
I remember when this was controversial
Numbers still small, but ballpark 1 in 3-5k is convergent estimate
PS this was always true
medpagetoday.com/opinion/second…

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More from @VPrasadMDMPH

Vinay Prasad, MD MPH 🎙️📷 Profile picture
4 Jan
Pre Vax 2020, FDA said 👇 they would not accept vaccine efficacy less than 50% (minimum bar)

Ontario data now suggesting a 3rd dose (booster) has Vax effectiveness of 37% for Omicron👇

Yet FDA & CDC advising booster FOR omicron?

Few thoughts 🧵
medrxiv.org/content/10.110… Image
We are no longer conducting adequately powered RCTs in the vaccine space.

Boosters for 12 to 15 are based on no efficacy data at all, as of yesterdays EUA 👇

Non inferior Geometric mean Ab titers is not a clinical endpoint

It can't show benefits>harms
There is a tension with an agency that explicitly said they would not approve a vaccine with a VE <50%, now advising a booster with a VE<50%, while simultaneously freeing the company of the obligation to test the booster in rigorous RCTs
Read 11 tweets
Vinay Prasad, MD MPH 🎙️📷 Profile picture
4 Jan
Our last article of 2021 (I think) is now out in the J of Cancer Policy @jcan_policy

We perform a survey of how many Satellites US Cancer centers have abroad

For instance, does Cleveland Clinic have branches in Dubai, Macau, Nigeria?

sciencedirect.com/science/articl…
🧵
@vkprasadlab Image
We searched the top 48 US cancer hospitals (<50 due to consolidation) and found that

46% had a partnership with a hospital overseas

19% had more than 1 clinic abroad
Some US hospitals have many satellites abroad 👇👇👇

I guess 3 rivers meet all over the world🤷‍♂️ Image
Read 8 tweets
Vinay Prasad, MD MPH 🎙️📷 Profile picture
3 Jan
Every school district not open tomorrow has failed it's kids and society

Public schools will need total reform/ replacement in the future. Vouchers/ charter are coming

Teachers unions destroyed a generation.

As a life long liberal, it was sad to watch
Public health 'experts' who don't understand tradeoffs aided and abetted the unions

Some even took $$$ from them

Sad to watch
School board showed they are comprised of total failures who don't prioritize kids' interests

Some don't even live in the district

Sad
Read 7 tweets
Vinay Prasad, MD MPH 🎙️📷 Profile picture
2 Jan
Dear Journalists,
There is a story here 👇 Phil Krause and Marion Gruber #2 &#1 at FDA vax have resigned over white house pressure on boosters.
Now FDA pushes this without advisory committee & with uncertain safety in boys.

Interview the 2 who resigned! 1/2
If a 12-15 year old boy already had 2 doses and has just had mild omicron what is the risk benefit of dose 3?

Ans: absolutely uncertain and possibly dangerous

Interview @walidgellad too

FOIA communication from WH to Peter Marks at FDA
The 2 people who resigned worked there for decades. They ar Director and Deputy Director. They are principled people.

And here is the shocker: they did NOT resign with the last guy!!
Read 4 tweets
Vinay Prasad, MD MPH 🎙️📷 Profile picture
28 Dec 21
It's amazing we made children as young as 2 wear a mask that has no evidence of benefit for prolonged periods of time, inflicting harm without upside.

Total policy failure, I wrote about it for the Atlantic months ago and MedPage before that

google.com/amp/s/amp.thea…
The fact nearly no one would say that the AAP and CDC were off their rocker to defy the World Health Organization and UNICEF to push this foolish recommendation down to 2 will be a shameful blemish on their reputations, I doubt they will recover in next 25 yrs.
Data from Spain, of regression discontinuity design, showed it did not work months ago. Sadly CDC pushed embarrassingly flawed studies in MMWR to defend their failed policy instead.

See Zweig, Atlantic.
Read 5 tweets
Vinay Prasad, MD MPH 🎙️📷 Profile picture
23 Dec 21
Our new @vkprasadlab article is now out in Cancer Reports

We tackle the frequency (spoiler alert: BRISK) of assessment of progression in RCTs of cancer drugs

Want to learn more?
onlinelibrary.wiley.com/doi/epdf/10.10…
[thread]
First, remember that progression free survival is a time to event, composite endpoint

It is typically the time until 1 of 4 things happen
Death, New lesions, Growth (without shrinkage) or Growth (from Nadir).

Watch my free lecture series to learn more:
As a result PFS is binned

It has a stair-step pattern b/c imaging is assessed not continuously, but at pre-specified time points
Read 8 tweets

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