Thread by @SMHopkins

I lead the #SIRENStudy and have been studying the impact of prior infection with COVID-19 and COVID-19 vaccinations on immunity for more than 18 months. We have published multiple studies with collaborators. The most recent preprint is available here medrxiv.org/content/10.110… 1/6

In this pre-print, which is under peer review, we demonstrate that 2 doses of vaccination on top of prior of infection, significantly reduces both asymptomatic & symptomatic infection compared to infection alone - Table 3 - the longer since primary infection the more effect 2/6

This is on top of the evidence provided in the original paper showing immunity 81-87% immunity with the original strains and early alpha period.... but just as immunity wanes from vaccines so it does from primary infection. 3/6
pubmed.ncbi.nlm.nih.gov/33844963/

We are currently starting to analyse the data from the Omicron wave... the consensus from immunologists & infection experts is getting a boost to your immunity from vaccination on top of prior infection will reduce asymptomatic & symptomatic infection -> reducing transmission 4/6

Our household all got infected in wave 1, both adults have had their three doses and was delighted to bring my teenager for his second dose to @GSTTnhs vaccination centre today. #getvacccinated #get boosted 5/6

& finally a huge thank you to all the #SIRENStudy participants and research teams for their commitment to this study over the last 18 months - 2 weekly PCR, monthly bloods, numerous questionnaires. And to collaborators from #PITCH, #Crick, #G2P, #Genomicc @UKHSA @NIHRresearch 6/6