Stop calling Omicron "mild".
It is NOT. In fact it is a major public threat and here is why: Allow me please,

Omicron is more infectious than Delta by a factor of 2.7-3.7.

If you are recovered from previous infection, chance of reinfection w/ Omicron is 5.4 times that of Delta
Researchers at UKHSA and NHS estimate the growth and immune escape of the Omicron variant in England.

They used data from for all PCR-confirmed SARS-CoV-2 cases in England who had taken a COVID test between November 29th and December 11th 2021.

They tested for Omicron..
They separated all non-Omicron case.

They use S-Gene Target Failure or genotyping as Omicron ID signals.

They found the proportion of Omicron among all COVID cases was doubling every 2 days up to December 11th.

Positive patients reported disease severity (how bad they felt)
They controlled for vaccine status, age, sex, ethnicity, asymptomatic status, region and specimen date, Omicron was associated with a 5.40 (95% CI: 4.38-6.63) fold higher risk of reinfection compared with Delta.

That's 5.4 times likely to get reinfected w/Omicron Vs. Delta
Let us put this in perspective: Incredible infectivity!

The UK “SIREN” study of COVID infection in healthcare workers estimated that prior infection afforded 85% protection against a second COVID infection over 6 months.

Reinfection protection from prior infection dropped!
The reinfection risk estimated in the current study suggests this protection has fallen to 19% (95%CI: 0-27%) against an Omicron infection.

That means this: If you've had a prior infection and thought that afforded you a protection level, then you are mistaken.
What about Vaccine effectiveness against Omicron?

vaccine effectiveness estimates against symptomatic Omicron infection up to 20% after two doses, and up to 80% after a booster dose.

This means Omicron found a way to EVADE OUR ACQUIRED IMMUNITY.
Therefore, based on this study it is clear to me that
2 vax doses or PI (prior Infection) is not good enough.

You need the booster.

Those who follow me know I've been highlighting Omicron's ability to evade our immunity and that we need an OSV plus continued modified booster
Prof Neil Ferguson said: “This study provides further evidence of the very substantial extent to which Omicron can evade prior immunity given by both infection or vaccination. This level of immune evasion means that Omicron poses a major, imminent threat to public health.”
Conclusion:
1. people must get the booster to optimize their protection against Omicron.

2. Omicron poses a major, imminent threat to public health.

3. Omicron is NOT mild. In fact it is scary as I see it because the next Omicron variant will likely evade our immunity even more
This thread explains why I think you should stop calling Omicron "MILD", and more points I've highlighted recently
@EricTopol @DrEricDing @ashishkjha @Craig_A_Spencer @DrTomFrieden @ScottGottliebMD @AlbertBourla
imperial.ac.uk/mrc-global-inf…

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Elias Said, MD, FACEP

Elias Said, MD, FACEP Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @MdFacep

9 Jan
If yet another mutation or variant of concern surges that more completely evades the antibodies people have built up, “we start all over,” ---Dr. Gregory Poland, head of the Mayo Clinic's Vaccine Research Group 1/4/2022

I stress that mutations happen during rampant surge
Omicron has an enhanced and focused affinity for the upper airways, replicating 70X more than delta and not invading the lower airway.
The resultant edema, inflammation, increased secretions are presenting as bronchiolitis, RAD, bronchospasms, and croup depending on the age group
It is predicted that the next variant of concern WILL arise before June of 2022.

The unprecedented explosive surge of new cases is the perfect petri dish for Omicron's next variant.

I keep citing basic principles in virology and immunology that so many clinicians forgot
Read 11 tweets
9 Jan
A week of attending duties and monitoring the trends across The US- Here is what I observed:

US has 93-97% Omicron now
Some states went this week from 10% to 66%
All should be at 97% by next week.
Hospitalizations rising.. For and with about 55% & 45%
The Booster raises your protection of reinfection & hospitalization close to 90% in > older than 65.

The problem is anything less than 3 dose (boosted) reinfection is very likely & hospitalization is about 5-10% of infected depends on risk status

US has only 36% boosted people
That means Omicron has about 256 Million people who aren't 3 dose, or boosted to go through.

I expect those vaxxed X2 w/prior infection to have less severe illness, and if not high risk, not be admitted

those less than 2 dose and PI, are most vulnerable

Get the booster!
Read 5 tweets
23 Mar 20
1/The absolute key to beating this pandemic is testing to identify any and all positive patients, isolating them until they test negative. This will temporize the pandemic allowing us time to develop therapeutic drugs, study therapeutics in clinical trials, and develop a vaccine
2/Lessons from Singapore and Wuhan,China should serve as lessons for us here. Containment is always the primary objective. Let us not give up on containment.
Mitigation is not appropriate for #coronavirus. That maybe okay for the flu, but not #COVIDー19
3/ We must test, test, and test some more. We must identify all positives and isolate them until they test negative. We must use technology and track all their potential exposed contacts and test/quarantine them. Social distancing, lockdown, and testing will contain this disease.
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

:(