My "there must be something wrong with this preprint" sense is tingling but it's hard to pinpoint.

medrxiv.org/content/10.110…

Summary: sniffer dogs can detect Long COVID patient sweat samples 51,1% of the time with a 0% false positive rate on controls.
Handlers are blinded to the sample locations, so not a Clever Hans effect. There's detail about how patients were sampled but not controls, though one presumes it's the same. I rather suspect unintentional scent marking distinctions, either in handling of samples...
... or in things that Long COVID patients tend to do (or not do) that the general public does not, rather than a dog-detectable odour eminating from their bodies. It's easy to accidentally mark samples with odours that humans cannot detect.
It's worth pointing out that even humans can do tracking to a surprising degree if only they put their nose to the ground:

researchgate.net/publication/66…

And even our inferior senses can readily detect the signs of recent traffic, such as newly crushed vegetation or disturbed soil.
But perhaps I'm just too pessimistic. Perhaps dogs actually can smell Long COVID on people. *shrug*

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More from @enn_nafnlaus

13 Jan
Really concerning paper. I really want to know the biological mechanism behind this.

nature.com/articles/s4159…

Summary:

(a) COVID patients (community-enrolled), whether with Long COVID (LC) or not (MC), have dramatically elevated interferon levels persisting 4 months after... Image
..infection - something not seen in uninfected controls (UHC) or people who caught "cold" coronaviruses (HCoV). As a reminder, interferons are cytokines sound the alarm call to viral infection and form a complex regulatory network of pro- and anti-inflammatory signals. Elevated..
...levels of pro-inflammatory interferons - as observed - promote aggressive T-cell responses; symptoms can range from asymptomatic to feeling ill to serious pathological states.

(b) While in non-Long COVID patients most IFN levels have significantly declined by 8 months, in...
Read 12 tweets
27 Dec 21
Thread: Mask Fit Testing

This evening, I decided to put all of my masks to a proper qualitative fit test using a nebulizer, bitrex solution, and improvised hood. From the upper left, counterclockwise:

1. HygoStar MP9017 surgical mask
2. Demetech DT-N95-FH N95 mask (Amazon)
3. Wisent BAU 4837 FFP2 mask (hardware store)
4. 3M Aura 9330+ FFP3 mask (Amazon; used for ~20h)
5. 3M Aura 9320+ FFP2 mask (Amazon; new)
6. 3M Aura 9330+ FFP3 mask (Amazon; new)
7. GVS Elipse SPR 644 P100 unvalved elastomeric respirator (Amazon)
8. 3M 6800 elastomeric full face respirator (valved) with 3M 2135 P3 R particle filters.

Test setup:

A cheap portable nebulizer was purchased on Amazon:

amazon.com/dp/B08FF3TW59?…

While you can test with stevia or saccharin, bitrex is generally considered to be the easiest...
Read 20 tweets
24 Dec 21
Interesting preprint on anosmia / dysosmia associated with SARS-CoV-2

medrxiv.org/content/10.110…

Summary: In SARS-CoV-2 patients, there's dramatic alteration of gene expression in the olfactory bulb of the brain, yet this doesn't correlate with the virus's presence or absence...
... in the olfactory bulb. Seeking to explain this, they checked for a marker of connectivity of sensory nerve fibres (afferants) called OMP-1, and as controls looked at a marker for olfactory lesions (TH) and general. neural activity (SNAP-25)

Results?
OMP-1 - the connectivity marker - was highly depleted in COVID patients (A) with anosmia, in comparison to non-COVID patients. No difference was seen in the marker for lesions (TH) or neural activity (SNAP-25). It thus appears that the pathology is upstream of the olfactory bulb. Image
Read 10 tweets
24 Dec 21
Hey @elonmusk, any way to rollback this horrid UI update? It's destroyed the usability of common controls on the bottom bar. Literally imposdible to have things like defrost and seat heaters as one-click. Is hiding "defrost" even legal? Shouldn't be.
Who designed this thing, and who approved it? All logic is gone. Like, if I swipe my music down off the screen, them swipe back up, it's not the music that comesup, but the giant climate control screen! Is that "intuitive" or "helpful"?
With all the things that vanished from the bottom bar, it's now mostly blank unused space, on the most important part of the screen - even if I fill the custom bar from the limited subset of choices.

What were designers thinking with moving wiper controls so far from the wheel?
Read 5 tweets
22 Dec 21
Finally found it!

pure.ed.ac.uk/ws/portalfiles…

Top line results:

* 35% as severe as Delta (which was in turn ~200x that of Wuhan-Hu-1) - in contrast with 95% as severe in the Imperial College report.

* 10x greater risk of reinfection than with Delta

* Boosters give 57%...
... protection against symptomatic infection.

The nuance:

* Age *is* controlled for. This is important, as 49% of Omicron cases were age 20-39.

* Vaccination status is controlled for, but past infection is not.

* Small sample size (15 hospitalized patients)
* They *do* appear to control for time bias with a Cox proportional hazards regression model.

* "Only individuals reporting symptoms at the time of test were included in this study" - Not sure why they're doing this, sounds like a good way to introduce bias.
Read 10 tweets
1 Dec 21
More detail on the preliminary Omicron data reported by Israel the other day:

jpost.com/health-and-wel…

Beyond the mentioned:
* +30% transmission
* boosted=90% protection v. infection (was 95%)

It's:
* boosted=93% protection vs. severe (same)
* 2,4x more severe strain than Delta
The 2,4x more severe ("those not inoculated have a 2.4 times greater chance of developing serious symptoms") runs contrary to the narrative being spun in some African nations that it's a "mild strain" - statements often made right before insisting on lifting the travel bans.
Statements that - I should add - were just repeated by an anonymous WHO official, along with claims that vaccine efficacy isn't reduced, and also demanding the lifting of travel bans:

news.sky.com/story/covid-19…

This is all so preliminary, though, so again, massive grain of salt.
Read 6 tweets

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