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AJ Leonardi, MBBS, PhD Profile picture
@fitterhappierAJ
Jan 13, 2022 • 3 tweets • 2 min read • Read on X
Interesting. Uchicago finds in a preprint a strong signature of T cell apoptosis in Covid- more than HIV, and a loss of naive T cells

I wrote about t cell apoptosis and a loss of naive T cells in frontiers in 2020 as being problematic
biorxiv.org/content/10.110… Image
Ian Ricksecker sums it up right here

Now maybe you guys get why I don't think you should just 'use your t cells' on this one?
Noone really believed the T cells were getting killed
I had to argue a lot with some people that thought Macaque T cells were controlling covid

Not worth it anymore, really. the writing is on the wall and you all can learn it from other sources
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More from @fitterhappierAJ

AJ Leonardi, MBBS, PhD Profile picture
Jun 22
@Bryce_Nickels This is absolutely false because he made a “noble lie” and said the N 95s would not work for the public to the public in order for there to be greater supply to healthcare workers only. This backfired.
@Bryce_Nickels The ethical approach was the truth. This is a similar noble lie by omission that the WHO made when they refused to declare Covid as airborne in order for impoverished health systems to provide “adequate” PPE per their regulations according to WHO standards
@Bryce_Nickels The end result was workers in impoverished systems were being given “adequate “PPE for droplet transmission, and many of them died, including sadly many in New York City.
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Apr 6
When will H5N1 will go Human to Human?
Which is deadlier?
"The Covid pandemic has prepared me for an H5N1 pandemic"
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Mar 30
Wow looks like Marc is advocating Zero Covid, welcome Marc!

Mitigations like mask-wearing, clean air, and acknowledging the harm of covid infections

Well done!

This is an advancement from saying infections will maintain immunity, advocating for infection prevention instead Image
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Although it is a falsehood that vaccintions will not be needed

SARS Cov 2 is a Sarbecovirus and unlike the other common cold viruses. It has enhanced pathogenicity and immune evasion

Also, endemic sars cov 2 would INFECT the vulnerable, not protect them Image
I sure hope people didn't listen and abandon vaccinations after 1 infection because they thought reinfections would be like a common cold!
Read 5 tweets
AJ Leonardi, MBBS, PhD Profile picture
Mar 29
I think the decrease in childrens performance following 2020 was due to the Neurological harm after they were coaxed into unsafe classrooms before vaccination

I think this will remain the dominant effect due to Covid's neurotropism on reinfection

theconversation.com/mounting-resea…
Some people are encouraged to obfuscate the risk of kids getting infected and they will continue to do so


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16.1% of reinfected children got Long covid after reinfection compared to 12.1% with only 1 infection

More reinfected individuals had persistent anosmia, an indicator of neuroinflammation
ncbi.nlm.nih.gov/pmc/articles/P…
Image
Read 4 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 26
I was a fellow at the National Cancer Institute for 4 years in immunotherapy of cancer

They paid for my PhD

I am happy to explain hypotheses for a potential SARS Cov 2 based increased risk of cancer:

1/4
There are multiple ways a virus can cause cancer directly & indirectly

One indirect way is by tempering immunity

The immune system surveils for wayward, cancerous, and precancerous cells, and kills them

SARS Cov 2 ages & dysregulates T cells
2/4
A second broad yet direct category is by Viral Oncogenes or mutagenesis

Some Viruses have proteins that can change expression or function of host genes & accelerate the formation of tumors by preventing cell death

Some viruses cause DNA errors to accumulate
3/4
Read 5 tweets
AJ Leonardi, MBBS, PhD Profile picture
Jan 24
In 2021 on TWIV, Vincent Raccaniello said my claims of T cell exhaustion risk were "Twitter Science™"

In 2024 I am pleased to see T cell exhaustion is Science™, Nature Immunology™, and Nature Medicine™ Science
Raccaniello is arrogant enough to the extent to reject an accurate scientific hypothesis on twitter and his TWIV podcast to the detriment of the public, without knowing enough about the subject It was completely irresponsible

Are you feigning ignorance? It was a perjorative.
Read 10 tweets

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