Joe Bianco Profile picture
Jan 17 6 tweets 3 min read
pubmed.ncbi.nlm.nih.gov/22380576/
9-Methyl-β-carboline
“β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF.”
pubmed.ncbi.nlm.nih.gov/21651332/
“9-Me-BC is a known inhibitor of monoamine oxidase A and monoamine oxidase B, and has been proposed for further investigation in the treatment of Parkinson's disease.” #MAOI
"...beyond its neuroprotective/neurorestorative & anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task...the behavioral effects may be assoc. w/ a stimulatory impact on hippocampal dopamine levels & dendritic & synaptic proliferation.”
pubmed.ncbi.nlm.nih.gov/15582589/
Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors
“Kinetics analysis revealed that β-carbolines from cigarette smoke were competitive, reversible, and potent inhibitors of MAO enzymes.”
pubmed.ncbi.nlm.nih.gov/16139309/
Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee
“Coffee is the most important exogenous source of these alkaloids in addition to cigarette smoking.”
#MAOIs #Psychotropical
“Inhibition of MAO enzymes by coffee and the presence of MAO inhibitors that are also neuroactive, such as beta-carbolines and eventually others, might play a role in the neuroactive actions including a purported neuroprotection associated with coffee consumption.”
#biohacking

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More from @JBianco215

Jun 3
“I do not believe Ancel Keys was a misguided scientist who really cared, [but] an egomaniac interested in pursuing his ambitions of becoming remembered for solving the mystery of heart attacks, regardless of whether or not he actually solved it, which he ironically made worse.”
“Heart attacks had been on the decline for awhile because people were smoking less and now that we're eating so much seed oil and it's in our body fat, heart attacks are again on the rise.”
“The American Heart Association had declared victory, saying heart attacks aren't going to be happening anymore, in 2010 ... but they are now just pretending they never said that.”
@drcateshanahan on @DavidGornoski ()
Read 4 tweets
Jun 3
doi.org/10.1371/journa…

In 1018 subjects, dietary trans fats were strongly significantly associated with greater aggression even after adjustment for confounders

Linolenic acid in vegetable oil converts to trans fat when heated, so you may be eating trans fats without knowing
ncbi.nlm.nih.gov/pmc/articles/P…

This study heated different oils at 180°C for 5 mins, and in ALL oils, the omega-6 PUFA content was significantly lowered because it was converting to trans fat.

This is much worse in restaurants where cooking oils are reused for up to a week at a time.
The public health crisis of omega-6 poisoning is not only a cause of obesity and degeneration, but also of mass psychosis and personality change.
If omega-6 and trans fats make everyone aggressive, how can we expect to collectively collaborate and empathize to solve problems? Image
Read 6 tweets
Apr 21
pubmed.ncbi.nlm.nih.gov/28733812/

Melatonin increases reactive aggression and cortisol.

In a game experiment, players given 5mg melatonin chose harsher punishments for their defeated opponents vs. players given placebo.

This was independent of baseline personality traits. Bar graph: Effects of melat...
The researchers suspected melatonin use could contribute to unethical behavior and stereotyped judgements.

pubmed.ncbi.nlm.nih.gov/9247986/
pubmed.ncbi.nlm.nih.gov/9694404/

Melatonin impairs logical reasoning and cognitive performance (slowed reaction times) partly by reducing brain temperature.
This isn't to say melatonin is bad, but it's a hormone and can cause issues in supraphysiological doses.

0.3-1mg is often plenty for sleep, but stores sell 5-10mg as the default, up to 20mg.

Our melatonin peaks to ~60pg/mL at night

1-5mg gives us 100-1000x that amount. "In normal young adult...
Read 6 tweets
Apr 19
“I used to be able to eat whatever I wanted but now that I'm older I store it all as fat.”

None of us actually “get away with it” even when we're young & fit. There is cumulative metabolic & epigenetic harm occurring when we make ultra-processed food staples in our lives.
Epigenetic factors respond to nutrition & other environmental influences in early development.

These elements comprise over 35% of the human genome.

“The specific composition of each individual's ‘epigenetic mosaic’ is influenced by early nutrition.”

ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…

Mice fed a high fat, high sugar diet became obese with metabolic syndrome and high blood glucose, cholesterol, and triglycerides.
Daughters of these obese mothers weren’t obese, but had abnormal glucose and insulin vs. daughters of mice fed a normal diet.
Read 4 tweets
Apr 19
🧵 There seem to be two schools of thought for macronutrient combining:

People like Jessie Inchauspé (@GlucoseGoddess) balanced their blood sugar by learning to buffer high-glycemic foods with healthy fat or protein. This stopped her sugar spikes and fixed many chronic symptoms.
And indeed, research found that in diabetics, fish or beef 15 minutes before rice lowers blood sugar by 30-40% compared to eating the rice first.
This is largely due to the fish and beef causing secretion of the gut hormone incretin, which slows motility, letting everything absorb slower and steadier (pubmed.ncbi.nlm.nih.gov/25613093/).
Read 14 tweets
Apr 18
Next to nutrition and environment, exercise is one of the most potent medicinal interventions. The brain (and mitochondrial) benefits still aren't discussed enough, and people often speak about how they feel like a “different person” when they exercise vs. when they don't.  “As long as a person exerc...
Exercise protects & upregulates the dopamine system. The drug MPTP mimics Parkinson's, destroying dopamine neurons, but exercise greatly protects those neurons & upregulates dopamine mRNA after the fact. It protects dopamine from all inflammatory damage.
pubmed.ncbi.nlm.nih.gov/20851176/
I met a man whose wife had Parkinson's. Vigorous exercise was the only thing that really helped her, significantly stalling her decline and giving her several more years of decent life. Unfortunately they didn't learn about nutritional options in time.
ncbi.nlm.nih.gov/pmc/articles/P…
Read 10 tweets

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