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Eric Topol

@EricTopol

Jan 18, 2022 • 6 tweets • 3 min read • Read on X

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New data mRNA vaccine 4th dose
timesofisrael.com/israeli-trial-…
—HCW, 154 Pfizer, 120 Moderna, + control group
—Increase in antibodies > 3rd dose
—Little effect on Omicron cases
—No data yet for ? severe disease, memory B/T cells, higher or more durable protection
—Uncertain benefit/need

@UKHSA

Last week @UKHSA published their new data on Omicron and 2 dose vs 3 dose vaccine effectiveness (VE) vs infections assets.publishing.service.gov.uk/government/upl…
In people w/o prior Covid, the booster approximately doubled VE, the 62% isn't bad (point estimate)
But

It falls off pretty fast, this vs Omicron (and Delta) symptomatic infections. So an important unresolved question is whether the 4th dose helps prevents this attrition of VE over time vs symptomatic infection and severe disease

Israel has given a 4th dose to well over 500,000 people (of 9 M population)
abcnews.go.com/International/…
Testing is aggressive (>8X US/capita) but this graph of their Omicron wave isn't encouraging vs infections with 3rd booster rate 54% (US 24%), 2-shot vaxx 64% (US 62%)

Last point, which I cannot emphasize enough:
3rd shot protection vs Omicron hospitalizations, severe disease, death is remarkably high, about as well preserved as 2 shots vs ancestral strain, and a very different look compared with VE vs infections
assets.publishing.service.gov.uk/government/upl…

Further highlighting this dichotomy in Israel
Impact of cases vs impact on severe disease/hospital or ICU admits/death
ourworldindata.org/covid-metrics-…

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More from @EricTopol

Eric Topol

@EricTopol

Feb 3

A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access
I review the background and major implications in a new Ground Truths edition (link in my profile)nature.com/articles/s4159…

The human brain:
—had 7-30 times more accumulation of microparticles (MPs) than the liver or kidney (organs with previously documented high propensity)
—from people with dementia had 5X accumulation of MPs compared with non-dementia
—there was a marked increase of accumulation over recent years

Your Health Alert washingtonpost.com/climate-enviro…

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Eric Topol

@EricTopol

Dec 31, 2024

Three new @NEJM reports on #H5N1 today
1. An overview by @MichaelGIsonMD and @DrJeanneM
"urgent need for vigilant surveillance of emerging mutations and assessment of the threat of human-to-human transmission"

2. Report of the 13-year-old Canadian girl who developed acute respiratory failure. Sequence of her H5N1 revealed 3 mutations that may be linked to higher virulence and adaptation to human cell binding

3. Review of 46 cases of mild H5N1 illness by CDC in 2024

Read 6 tweets

Eric Topol

@EricTopol

Dec 9, 2024

We're learning how to control the immune response, like a rheostat, even in the brain. Implications for understanding the basis and potential treatment of autoimmune conditions like multiple sclerosis, #LongCovid, #MECFS, and brain cancer.
A brief review of 6 recent, important reports
in the new Ground Truths, open-access

Such as Programming T cells with brain-specific proteins and payloads
@ScienceMagazine science.org/doi/10.1126/sc…

Or peptide fragments of myelin basic protein that suppress the immune response @Nature nature.com/articles/s4158…

Read 4 tweets

Eric Topol

@EricTopol

Nov 13, 2024

New @NEJM
A whopping (~90%) reduction of progression to Type 2 diabetes with tirzepatide (GLP-1 drug, dual receptor) vs placebo in a randomized trial of >2,500 participants with obesity, absolute reduction of 10/100 treated

by @AniaJastreboff and collaboratorsnejm.org/doi/full/10.10…

In other GLP-1 new publications today
—Country-wide Sweden reduced hospitalizations for alcohol or substance abuse with these drugs
jamanetwork.com/journals/jamap… @JAMAPsych
—Concerns about discontinuation
jamanetwork.com/journals/jama/… @JAMA_current

Other new anti-obesity drugs in the pipeline, one that also increases energy expenditure
@NatureNV nature.com/articles/d4158…

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Eric Topol

@EricTopol

Nov 13, 2024

A dedicated issue of @ScienceTM on #LongCovid
—Sex-specific differences, with perspective by @VirusesImmunity and @SilvaJ_C
—Insights for therapies @AndreaCoxMDPhD
—Deconvoluting "Osler's Web" @MichaelPelusoMD @DeeksSteven @DrMaureenHanson @SaydahSharon
—+RECOVER Trial, Lyme disease

science.org/toc/stm/16/773

Where we have failed to date: finding an effective therapy. That has to change
science.org/doi/epdf/10.11…

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Eric Topol

@EricTopol

Oct 19, 2024

An elegant @Nature study by @AkassoglouLab has illuminated our understanding of the role of fibrin (component of blood clots), #SARSCoV2, and brain inflammation in Covid and #LongCovid.
This discovery and more in the new Ground Truths podcast, with transcript, key figures (such as as the one below) and citations. Open-access. Link in my profile.

A clip from our conversation. Unknowingly, @AkassoglouLab was gearing up for understanding this complex pathophysiology for many years before Covid hit