#akcomicron
OMICRON-- DIFFERENT MODE OF CELL ENTRY
more cell types infected
"uses an endosomal pathway for entry that increases number of cell types it can infect. This switch of entry pathway could explain increase in transmissibility of Omicron variant"
news-medical.net/news/20220109/…
OMICRON-- DIFFERENT MODE OF CELL ENTRY
more cell types infected
"uses an endosomal pathway for entry that increases number of cell types it can infect. This switch of entry pathway could explain increase in transmissibility of Omicron variant"
news-medical.net/news/20220109/…
DRUGS BLOCKING ENDOCYTOSIS
omicron variants
*HCQ
*NITAZOXANIDE
omicron variants
*HCQ
*NITAZOXANIDE
https://twitter.com/__ice9/status/1289197709975384069?t=ikgn7CsL0ANA8dmxqbZ_Hw&s=09
OMICRON-- NEW TREATMENT HORIZONS
mefloquine and artemisins as new drugs inhibiting endocytosis
"Antimalarial Quinolines and Artemisinin Inhibit Endocytosis in Plasmodium falciparum"
journals.asm.org/doi/10.1128/AA…
mefloquine and artemisins as new drugs inhibiting endocytosis
"Antimalarial Quinolines and Artemisinin Inhibit Endocytosis in Plasmodium falciparum"
journals.asm.org/doi/10.1128/AA…
*omicron don't need spike proteins for viral entry and evades ABs
*omicron uses endocytosis route for entry
*ADE process uses endocytosis as exclusive route of entry
*endocytosis route enables coV2 to infect multiple types of cells offering more widespread clinical symptomatology
*omicron uses endocytosis route for entry
*ADE process uses endocytosis as exclusive route of entry
*endocytosis route enables coV2 to infect multiple types of cells offering more widespread clinical symptomatology
*omicron don't need spike proteins for viral entry and evades ABs
*omicron uses endocytosis route for entry
*ADE process uses endocytosis as exclusive route of entry
*endocytosis route enables coV2 to infect multiple types of cells offering more widespread
*omicron uses endocytosis route for entry
*ADE process uses endocytosis as exclusive route of entry
*endocytosis route enables coV2 to infect multiple types of cells offering more widespread
https://twitter.com/BlackSanta911/status/1483449907025436680?t=1yTsYjVyV8zIF0Orwc4HKQ&s=09
"‘KILLER’ IMMUNE CELLS STILL RECOGNISE OMICRON VARIANT.... OH REALLY?"
https://twitter.com/GVDBossche/status/1482819512902762496?t=JFr66SKNz4IQuW8u4D53uA&s=19
NEVER ACCEPTED ACE2 AS EXCLUSIVE ROUTE OF ENTRY
large no of symptomatic cases were expected,considering unprotected ace2 route. but this was never seen.
perhaps due to,
variable expression of ace2/TMPRSS2 route"
PREDOMINANT/SIGNIFICANT ANOTHER ENTRY ROUTE
large no of symptomatic cases were expected,considering unprotected ace2 route. but this was never seen.
perhaps due to,
variable expression of ace2/TMPRSS2 route"
PREDOMINANT/SIGNIFICANT ANOTHER ENTRY ROUTE
https://twitter.com/drakchaurasia/status/1348280167903367172?t=mIToi89FPGpO_3fuoAJgZg&s=09
OMICRON- WHEN ACE2 IS NOT IN USE
When TMPRSS is blocked:
- HCQ works
(also implies:)
- nitazoxanide/niclosamide work better
Consistent with RCT efficacy for bromhexine+HCQ in Ansarin et al., which reduced mortality by 100% in moderate hospitalized cases.
When TMPRSS is blocked:
- HCQ works
(also implies:)
- nitazoxanide/niclosamide work better
Consistent with RCT efficacy for bromhexine+HCQ in Ansarin et al., which reduced mortality by 100% in moderate hospitalized cases.
https://twitter.com/__ice9/status/1352524041719074816?t=Dwaue-_DHddl6dNlijq0FQ&s=19
"India and China both developed inactivated vacs
this indicates that atleast these two nations have scientists who are not blindfolded following western block.
not only vacs, in whole approach towards pandemic management, these two nations have performed far better than west"
this indicates that atleast these two nations have scientists who are not blindfolded following western block.
not only vacs, in whole approach towards pandemic management, these two nations have performed far better than west"
OFTEN I GO OFFLINE AND IN THINKING MODE
an old thread on 3rd wave
*we receive info,we transmit info,we analyse info,that's our modus operandi
*today,after 20 days of near deep silence, I encountered 2 covid cases with spO2 ~47-64%
*one was having symptoms
an old thread on 3rd wave
*we receive info,we transmit info,we analyse info,that's our modus operandi
*today,after 20 days of near deep silence, I encountered 2 covid cases with spO2 ~47-64%
*one was having symptoms
https://twitter.com/drakchaurasia/status/1406282724214665218?t=Gepb6ddUALjKIGEhj60xdg&s=09
USE OF IDENTIFYING VARIANTS
*to evaluate their infectivity and pathogenicity
*evaluating the magnitude of threat to people
*preparedness and ascertain containment measures
*planning drug protocols/developing vacs
*short-term and long-term strategies development
*future threats
*to evaluate their infectivity and pathogenicity
*evaluating the magnitude of threat to people
*preparedness and ascertain containment measures
*planning drug protocols/developing vacs
*short-term and long-term strategies development
*future threats
CHENNAI: 3 OUT OF 10 PATIENTS WITH FLU SYMPTOMS TEST POSITIVE FOR COVID
"1,497 patients based on data as symptomatic patients who skipped coronavirus testing on January 18.Corporation tested all patients and found 455 cases to be positive for virus"
news.abplive.com/tamil-nadu/che…
"1,497 patients based on data as symptomatic patients who skipped coronavirus testing on January 18.Corporation tested all patients and found 455 cases to be positive for virus"
news.abplive.com/tamil-nadu/che…
THERE ARE MANY UNANSWERED QUESTIONS IN THIS PANDEMIC
*ACE2 density is found lowest in lungs. then why lungs more involved with original coV2. who is said to have ace2 as major route of entry?
ncbi.nlm.nih.gov/labs/pmc/artic…
*ACE2 density is found lowest in lungs. then why lungs more involved with original coV2. who is said to have ace2 as major route of entry?
ncbi.nlm.nih.gov/labs/pmc/artic…
1/2
*if, we are deliberately/unknowingly stuffed with wrong and misleading informations
*ace2 was never a major route of entry in coV2
*endocytosis was route of entry for cov2 from very beginning
ncbi.nlm.nih.gov/labs/pmc/artic…
*if, we are deliberately/unknowingly stuffed with wrong and misleading informations
*ace2 was never a major route of entry in coV2
*endocytosis was route of entry for cov2 from very beginning
ncbi.nlm.nih.gov/labs/pmc/artic…
1/3
*some other pathway causing pneumonia in covid.omicron is having different MOA
*why all of a sudden coV2 lost it's lethality? was pneumonia (hypoxia) only lethal pathology?
*are spike proteins of omicron and delta innocent and that of coV2 and vacs lethal?
*WHAT WE DON'T KNOW
*some other pathway causing pneumonia in covid.omicron is having different MOA
*why all of a sudden coV2 lost it's lethality? was pneumonia (hypoxia) only lethal pathology?
*are spike proteins of omicron and delta innocent and that of coV2 and vacs lethal?
*WHAT WE DON'T KNOW
INDIA GOES OFF THE RECORD
states using kits to protect people
"My state government is also giving Iv... based home isolation kit. I will post in few days. Most governments are distributing unofficially to avoid conflicts with ICMR"
states using kits to protect people
"My state government is also giving Iv... based home isolation kit. I will post in few days. Most governments are distributing unofficially to avoid conflicts with ICMR"
DELTA IN WESTERN ZONE
my opinion,
*it was same delta,but two factors made it expressing differently
*vacs/ABs status making it more aggressive
*undercurrent of drug use in community,reduced fatalities
reduced fatalities in west were due to delta,and off the record drug use
my opinion,
*it was same delta,but two factors made it expressing differently
*vacs/ABs status making it more aggressive
*undercurrent of drug use in community,reduced fatalities
reduced fatalities in west were due to delta,and off the record drug use
IVERMECTIN IN INDIAN STATE OF UTTAR PRADESH - UNSTOPPABLE
that is how we quashed covid
"officials called us several times, visited our place, tested us & gave us covid drug kit! This is such a great service to the public"
that is how we quashed covid
"officials called us several times, visited our place, tested us & gave us covid drug kit! This is such a great service to the public"
https://twitter.com/srivastavasahib/status/1483363190746484737?t=67oq24mGrcVViHq9D4o7vA&s=19
OVERREACTING OF DECEIVED
covid has done something to my neurones.
made it over-reacting
or, made it extremely sensitive
but, i have some apprehensions that things are not really smoothening.
something is missing.
perhaps, we over relying on data
data deceiving,but my senses not
covid has done something to my neurones.
made it over-reacting
or, made it extremely sensitive
but, i have some apprehensions that things are not really smoothening.
something is missing.
perhaps, we over relying on data
data deceiving,but my senses not
HOW WE SURVIVED, FROM A LETHAL WAVE
"during second wave of covid, i was surrounded by 60-80 covid pts daily.
it was an ordeal for me to save ourselves, my family, staff and relatives, living distantly.
two of my relatives succumbed to covid. rest of all were well recovered"
"during second wave of covid, i was surrounded by 60-80 covid pts daily.
it was an ordeal for me to save ourselves, my family, staff and relatives, living distantly.
two of my relatives succumbed to covid. rest of all were well recovered"
VIRAL SHEDDING AND PERSISTENCE IN COVID
CAN HYPOXIA COME BACK, IN COVID?
*threat is not over
*western block terribly need to review their protocols
"ketan, re hypoxia, what theory i have in my mind,
threat is not over yet.
just a single mutation in any of new variant, may bring it back"
*threat is not over
*western block terribly need to review their protocols
"ketan, re hypoxia, what theory i have in my mind,
threat is not over yet.
just a single mutation in any of new variant, may bring it back"
https://twitter.com/drakchaurasia/status/1486637377858641925?t=Pq71XUtjARMy8fNileyL6w&s=09
THREAT FOR NEW COVs IS THERE
be it natural or man made?
"only one mutation is required for virus to infiltrate human cells.research findings stated tht novel coronavirus poses a risk because it binds to ACE2 receptor differently than coronavirus pathogen"
news18.com/news/india/1-i…
be it natural or man made?
"only one mutation is required for virus to infiltrate human cells.research findings stated tht novel coronavirus poses a risk because it binds to ACE2 receptor differently than coronavirus pathogen"
news18.com/news/india/1-i…
DO BINDING DIFFERENTLY TO ACE2,
OPENS A NOVEL POSSIBILITY OF ACEi AND ARBs BE EFFECTIVE IN THIS NEW NEO-COV?
@OutOfTheDarkAge
@sanchak74
OPENS A NOVEL POSSIBILITY OF ACEi AND ARBs BE EFFECTIVE IN THIS NEW NEO-COV?
@OutOfTheDarkAge
@sanchak74
https://twitter.com/drakchaurasia/status/1486968850583539712?t=DZRlsWpMoQHEKQdk8kIdPA&s=19
NEW coV EPICENTER?
"between NIH and South African Medical Research Council, U.S.-South Africa Program for Collaborative Biomedical Research continues into Phase 2* with four new funding opportunity announcements (FOAs).NIAID is one of five NIH institutes"
niaid.nih.gov/grants-contrac…
"between NIH and South African Medical Research Council, U.S.-South Africa Program for Collaborative Biomedical Research continues into Phase 2* with four new funding opportunity announcements (FOAs).NIAID is one of five NIH institutes"
niaid.nih.gov/grants-contrac…
WE DON'T KNOW WHICH LAB
"there was an account from an Italian virologist – Nicola Bidoli – removed from Twitter, shortly after having claimed that Omicron is a lab-made live attenuated vaccine
they were doing experiments on mice in a lab in South Africa"
covexit.com/lab-origin-of-…
"there was an account from an Italian virologist – Nicola Bidoli – removed from Twitter, shortly after having claimed that Omicron is a lab-made live attenuated vaccine
they were doing experiments on mice in a lab in South Africa"
covexit.com/lab-origin-of-…
DRUGS KILL COV2
antiviral pills target molecular machinery virus uses to make copies of itself inside cell
Omicron only has a few changes to this machinery,which makes it more likely that drugs will retain their ability to disrupt this replication process
m.economictimes.com/news/internati…
antiviral pills target molecular machinery virus uses to make copies of itself inside cell
Omicron only has a few changes to this machinery,which makes it more likely that drugs will retain their ability to disrupt this replication process
m.economictimes.com/news/internati…
THE NEXT PANDEMIC
a thread on 'making of a pandemic'
"2017: Anthony Fauci, stated at Georgetown University: there'll be a surprise-pandemic outbreak during the Trump presidency.
In hindsight: Marvelous forecasting skills, all Gates-affiliates share"
a thread on 'making of a pandemic'
"2017: Anthony Fauci, stated at Georgetown University: there'll be a surprise-pandemic outbreak during the Trump presidency.
In hindsight: Marvelous forecasting skills, all Gates-affiliates share"
https://twitter.com/Bobby_Network/status/1380803050902847491?t=GIwOwT1wJdKHmDeX_vALkg&s=09
BY REINFECTION I MEAN
*omicron reinfection in a person who is naturally infected or vacced
*delta reinfection in person who is naturally infected or vacced
*Alfa reinfection in a person who is vacced with any vacs other than inactivated one
*any variant causing ADE in vacced
1/1
*omicron reinfection in a person who is naturally infected or vacced
*delta reinfection in person who is naturally infected or vacced
*Alfa reinfection in a person who is vacced with any vacs other than inactivated one
*any variant causing ADE in vacced
1/1
1/2
SEVERITY OF ILLNESS IN REINFECTION
*omicron causes mild to moderate disease in all, with non-lethal outcome
*delta milder on unvacced, naturally infected and vacced with inactivated vacs
*delta harder on vacced
*ADE is always severe disease.ending fatally if not managed well
SEVERITY OF ILLNESS IN REINFECTION
*omicron causes mild to moderate disease in all, with non-lethal outcome
*delta milder on unvacced, naturally infected and vacced with inactivated vacs
*delta harder on vacced
*ADE is always severe disease.ending fatally if not managed well
ENDING THE DARK AGE OF DISINFORMATION AND AUTHORITARIANISM?
totalitarianisms costing 5.6 million lives
"Japan's Kowa says ivermectin effective against Omicron in phase III trial"
totalitarianisms costing 5.6 million lives
"Japan's Kowa says ivermectin effective against Omicron in phase III trial"
https://twitter.com/Covid19Crusher/status/1488063184317685760?t=xv-4krW5leZPYMVBgjdUSA&s=09
*OMICRON, due to it's ancestral linkage to primitive genomes of coVs, has no tendencies of hypoxia or ADE
*lineage from those genomes, didn't show predictions for lung parenchyma too
*DELTA, being lineage of SARS-coV2 has all properties of it including ADE,in much attinuated form
*lineage from those genomes, didn't show predictions for lung parenchyma too
*DELTA, being lineage of SARS-coV2 has all properties of it including ADE,in much attinuated form
DATA BASED STUDIES VS OBSERVATIONAL STUDIES
*people are blind towards observational studies
*all people on earth can't generate data of your quality
*you have the duty to find the truth embedded in a different format
*and, convert it to your data format
*people are blind towards observational studies
*all people on earth can't generate data of your quality
*you have the duty to find the truth embedded in a different format
*and, convert it to your data format
OMICRON AND OTHER HUMAN CORONAVIRUSES
*these species of coronaviruses,different affinities for human respiratory tract and different clinical patterns
*prevalent globally,not necessarily lethal or causing severe disease.
*omicron follows genomic expressions different from coV2
*these species of coronaviruses,different affinities for human respiratory tract and different clinical patterns
*prevalent globally,not necessarily lethal or causing severe disease.
*omicron follows genomic expressions different from coV2
COMMUNITY TRANSMISSION OF OMICRON IN DELHI
"breakthrough infections, decreased hospitalization rates, and less of symptomatic disease among individuals with high seropositivity against CoV-2 infections.
definite shift from Delta predominance to Omicron"
medrxiv.org/content/10.110…
"breakthrough infections, decreased hospitalization rates, and less of symptomatic disease among individuals with high seropositivity against CoV-2 infections.
definite shift from Delta predominance to Omicron"
medrxiv.org/content/10.110…
ADE, ENDOCYTOSIS VS OMICRON+DELTA
*omicron using full ADE mechanism to enter cell,ie endocytosis
*omicron has less infectivity than delta, but this entry mode makes it is faster in vacced
*excessive number of vacced in community, making good place to delta causing severe illness
*omicron using full ADE mechanism to enter cell,ie endocytosis
*omicron has less infectivity than delta, but this entry mode makes it is faster in vacced
*excessive number of vacced in community, making good place to delta causing severe illness
ENDOCYTIC ENTRY ROUTE AND ALTERED CELLULAR TROPISM,
OMICRON PRESENTING DIFFERENTLY
"Omicron’s less efficient spike cleavag at S1/S2 is associated with shift in cellular tropism away from TMPRSS2 expressing cells,with implications for altered pathogenesis"
nature.com/articles/s4158…
OMICRON PRESENTING DIFFERENTLY
"Omicron’s less efficient spike cleavag at S1/S2 is associated with shift in cellular tropism away from TMPRSS2 expressing cells,with implications for altered pathogenesis"
nature.com/articles/s4158…
TAKING ADVANTAGE OF LIMITATIONS OF ADE
theoretically no vacs is possible in coVs.
but,ADE has some limitations which can be used to people's advantage.
*natural infection and inactivated vacs confer ABs, of which, few are possibly with neutralizing abilities
1/1
theoretically no vacs is possible in coVs.
but,ADE has some limitations which can be used to people's advantage.
*natural infection and inactivated vacs confer ABs, of which, few are possibly with neutralizing abilities
1/1
1/2
*after 6 months of vacs or natural infection, no fear of ADE. because, no ABs are there
*T cells persists and give long-term immunity. during this period, any vacs, will be safe and confer ABs.
*in this situation, all vacs will be safe, efficacy depends upon epitomes included
*after 6 months of vacs or natural infection, no fear of ADE. because, no ABs are there
*T cells persists and give long-term immunity. during this period, any vacs, will be safe and confer ABs.
*in this situation, all vacs will be safe, efficacy depends upon epitomes included
1/3
*natural infection and inactvated vacs are relatively successful due to multiple epitomes and broad-spectrum of ABs
*this justifies the assertions that vacs shouldn't be used in between a pandemic
*natural infection and inactvated vacs are relatively successful due to multiple epitomes and broad-spectrum of ABs
*this justifies the assertions that vacs shouldn't be used in between a pandemic
WHY COVAXIN NOW,
WHY NOT OMICRON?
you got best covid vacs, the natural one.
OMICRON has spikes which are incapable of splitting into S1 and S2.
but, fully capable of conferring ABs against S proteins.
along with ABs to other epitomes including N proteins.
biorxiv.org/content/10.110…
WHY NOT OMICRON?
you got best covid vacs, the natural one.
OMICRON has spikes which are incapable of splitting into S1 and S2.
but, fully capable of conferring ABs against S proteins.
along with ABs to other epitomes including N proteins.
biorxiv.org/content/10.110…
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