How does light exposure affect circadian rhythms and sleep cycles? This review article provides an analysis of many studies exploring the effects of different wavelengths and durations of light exposure on sleep. I was curious about blue vs. red-orange:

tandfonline.com/doi/abs/10.108…
“Appleman et al. (2013) conducted a 12-day study where 21 subjects, randomly divided into two groups, received either short-wavelength (blue, peak 476 nm) light for 2h in the morning and light filtered (<535 nm) with orange-tinted glasses for 3h in the evening (advance group)…”
“…or at opposite times, that is orange-tinted glasses in the morning and blue light in the evening (delay group). Subjects kept their normal schedule for the first 5d and received morning and evening light exposures the following 7d in addition to a fixed sleep schedule…”
“…(advanced by 90 min from the baseline). The study showed that the direction of circadian phase change is determined by the light-dark exposure, not by the fixed sleep schedule, and that both morning and evening light exposures need to be controlled to shift circadian phase.”
“After 7 days on the fixed 90-min advanced sleep schedule, circadian phase advanced by 132 ± 19 min in advance group and delayed by 59 ± 7.5 min in delay group.”
Meaning blue light exposure in the morning and orange at night shifted sleep cycles more than 2 hours earlier, while subjects stayed up an hour later with these cycles in reverse.
Lighting is one of the most important factors for sleep and circadian rhythms. If you struggle with sleep hygiene, it is definitely recommended to avoid blue and colder white lights in the hours before sleep.
Anecdotally, I’ve found that orange-red lights help tremendously with falling asleep in the evening, and that a few hours of exposure to warmer colored lights improves sleep quality. Also, it is easier to work for long hours if the lights do not remain the same color.

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More from @nanogenomic

Jan 13
EXPONENTIAL THINKING

…and why it is so important to understand with pandemics…

🧵
Some basic math on exponents:
y = x(r^n)
d = x(r^n)/c

If r is # of people infected per case (R0)
x is starting # of cases
n is number of exponential infection increases
1/c is fraction of cases leading to death

Then y is cases at time point n and d is deaths at time point n.
People must understand that cases increasing exponentially more (e.g. if r is twice as high between omicron and delta / wildtype) means that half, quarter or even 1/10th lethality per case will yield more deaths than if this exponent isn’t in place.
Read 6 tweets
Dec 31, 2021
We can do better.
I am an optimistic realist. I believe in our capacity to harness technology to improve the world and offset almost any kind of problem. The progress of scientific innovation is stunning and there is much to be grateful for. However, it is not a time to pat ourselves on the back.
Two years in, and messages like this were swiftly ignored and continue to be downplayed. We are not through the woods yet.
Read 8 tweets
Dec 30, 2021
Here is a comparison of actual Walgreens stock with what happens when you try to buy a rapid test for COVID. Impossible to do with @Uber, @Postmates, or @Instacart. Thousands of extra tests could be delivered in San Francisco if delivery services updated their catalogues.
Actual catalogue (<500 Abbott tests available in all of San Francisco Walgreens)
Rapid tests aren’t even SHOWN on the list of items that can be ordered.
Read 5 tweets
Dec 28, 2021
Spent several hours today attempting to get a rapid test. Tried Instacart, which failed, then went to Walgreens, Safeway, called two CVSes, checked online catalogues and attempted to see in-store inventories at each pharmacy, and finally was able to schedule a test at a clinic.
The test is tomorrow, and I have to walk to the clinic again, at which point the results will take 48-72 hours to turn around.
While on the East Coast for most of this year, testing was much easier. Resources existed for free next-day PCR text delivery, and NYC had pop-up testing sites everywhere.
Read 4 tweets
Dec 27, 2021
Eagerly awaiting 2022’s global COVID policy… happy holidays y’all!
Hopefully, this year:
1) rapid tests can be received by every US household free of cost and same-day / next-day
2) we can update vaccines beyond the wildtype, Wuhan sequence
3) “COVID is airborne” is understood globally and accepted by WHO
4) better therapeutics
5) better masks
6) better ventilation and filtration systems in schools and workplaces
7) more global vaccine equity
8) more awareness and emphasis on prevention and treatment of long-COVID / viral-driven ME/CFS
9) more funding for therapeutics outside of monoclonals and Pfizer/Merck
Read 4 tweets

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