Myoung Cha Profile picture
Jan 23 12 tweets 5 min read
1/ The pandemic has felt endless, so the beginnings seem like a distant memory. Does anyone remember the worst-case model of 1.5-2.2m deaths that the White House used to “shock and awe” in March ’20?

To date, there have been 864k deaths in the US.

A look back below🧵 Image
2/ Before this press conference, Trump compared COVID to the flu with only “22 deaths”, “life & the economy go on.”

Sound familiar?

If only the current death rate — with all of the advantage of our vaccines and therapeutics — were as low as the flu today. Image
3/ The current 7-day average of COVID deaths is 2k+/day with yesterday's number of 3,866 deaths being one of the worst days ever during the pandemic.

At this rate, this is a 20-50x difference from what the average flu season is like!
4/ Going back to early 2020, there were strong reactions to this WH prediction of hundreds of thousands of deaths.

I’ll never forget @MikeFrancesa’s reaction at the time. Worth a listen if you didn’t hear it:

Image
5/ There were of course naysayers who said that the projections were overblown, even inside the White House. Image
6/ While the Trump administration could have saved more lives, the same could be said for Biden’s first year where more people have now died (400k+) than during the Trump era.

IMO, there is plenty of blame to go around for preventable deaths.

news.yahoo.com/dr-deborah-bir…
7/ The lack of national unity in promoting vaccines in late 2020 after the election was a missed opportunity, which likely contributed to vaccine hesitancy throughout 2021.

politico.com/news/2020/12/1…
8/ Would it be shocking for deaths to reach the worst case scenario of 1.5m+ deaths?

Yes it would, but we could reach that shocking milestone by 2023 if the mortality rate doesn’t improve from the 1,500-2,000 daily deaths the US has averaged over the last several months.
9/ We all welcome the arrival of the oral therapies as the silver bullet, but we have had other "savior" therapies to reduce mortality that did not exist in March 2020 — remdesivir, dexamethasone, convalescent plasma, monoclonal antibodies.

And yet here we are.
10/ Unless something materially changes, we have considerably more disease burden ahead. There are >100 million under-vaccinated and immunocompromised people in the United States, which is a very large pool of susceptible people at risk of death. Image
11/ With the failure of the federal vaccine mandate and a pretty dug in group of people who will never get vaccinated, we may be stalemated as a society where we have to grow used to a “new normal” of excess death.

newsweek.com/poll-unvaccina…
12/ As we approach the two-year mark of this White House press conference, I wonder if there is a Deborah Birx in the current administration who has second thoughts about our current path forward. Image

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More from @cha_myoung

Jan 25
1/ Japan has fared better throughout COVID than most western countries (146 deaths/million vs. 2,590 deaths/million in the US) despite:
- Very low public trust in gov’t
- Less trust in science
- No mandates

How has this been done and what can we learn? 🧵
nytimes.com/2022/01/24/opi…
2/ This trope around Confucius societies “winning the COVID-19 war” with “authoritarian mentalities” doesn’t neatly apply to Japan where only 4% of people surveyed in 2020 say they trust the government “a lot”, compared to 9% in the US and 12% in the UK.

wellcome.org/reports/wellco… Image
3/ Japan has led the way with vaccines among the G-7 without a government mandate and way higher vaccine hesitancy pre-COVID than the U.S. Image
Read 13 tweets
Jan 18
My ten “surprises” in healthcare for 2022 — events that the average person would only assign a one out of three chance of taking place but which I believe have a better than 50% likelihood of happening. Styled after Byron Wien’s annual predictions. 🧵

blackstone.com/news/press/byr…
#1: There is at least one new variant that emerges in 2022 that drives another omicron-sized surge of cases and hospitalizations, putting renewed stress on the healthcare system.
#2: Employers capitulate in mandating in-person return-to-work (with a few notable exceptions) for 2022. A widely distributed workforce enhances the value proposition of national, scaled healthcare players and virtual solutions.
Read 11 tweets
Jan 16
1/ How “mild” is omicron?

When compared against Delta hospitalization and death rates, the numbers look better.

When you look at how sick people are when they seek care, the data tells a different story.

Some data from @CarbonHealth since early December 2022 thru present🧵
2/ Symptomatic COVID+ patients are showing up to our clinics with more symptoms than COVID- patients presenting with flu-like symptoms:

3 or more symptoms: 58% (+) versus 43% (-)
4 or more symptoms: 38% (+) versus 25% (-)
3/ Most common COVID+ symptoms are cough (65%), sore throat (51%), headache (45%), and runny nose (45%).

COVID+ symptoms are 1.5-2.0x overweight cough and fever compared to COVID- patients
Read 6 tweets
Jan 13
1/ Even with the Supreme Court invalidating the Biden vaccine mandate, large companies are likely to take matters into their own hands with “sticks” (versus “carrots”). Even with a “mild” variant, economic consequences are significant enough to impact corporate behavior 🧵
2/ With hospitalizations surging (with fewer deaths) among the unvaccinated, the bill will come due at some point — to the tune of $20,000+ per hospitalization.

healthsystemtracker.org/brief/unvaccin…
3/ Beyond hospitalization costs, the higher case rates of unvaccinated people have implications for productivity loss due to absence along with short-term disability costs. Chart below shows the trend for NYC.
Read 11 tweets
Jan 10
1/ With the omicron wave putting untold pressure on staffing across a wide variety of industries, it is not inconceivable for these staffing shortages to become more “endemic” with behaviors that have likely changed forever. 🧵
2/ An estimated 5 million people are isolating at home due to omicron, which could “deal a significant hit to the economy over the next month or two.”

wsj.com/articles/omicr…
3/ In historical flu seasons, the current omicron-driven work absentee rate would be ~2x the average peak of workplace absence due to all illnesses in the US (largely flu).
Read 14 tweets
Jan 6
1/ One of the biggest policy failures over the last 2 years is the lack of COVID testing, particularly evident now with omicron — both the supply and the quality of what we have available at scale. Where is our Operation Warp Speed for diagnostics? 🧵
2/ Based on the sheer scale of testing volume, it’s clear many are concerned with exposure to omicron and are not yet “done with COVID”. Labs are reporting >1.5 million PCR tests per day right now. But this is a massive underestimate of the total volume w/antigen tests in the mix
3/ Based on recent disclosures, the leading antigen test kit mfg. production volumes right now are estimated to be ~120 M tests/month

@AbbottNews: 50 M/month
@QuidelDX: 70 M/month

This is ~4x the reported daily PCR volume with a clear hunger for even more from consumers.
Read 16 tweets

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