Thread by @fitterhappierAJ

This paper came out months after my preprint osf.io/2egsm/ but 2 weeks before my paper doi.org/10.3389/fimmu.… where I claimed T cell memory was contributing to harm in covid

It's cited 33 times and mine only 2

Balloux has made me self conscious about my H index lol

It's got such a feel-good title, "T cells- Warriors of sars cov 2 infection" Monica Gandhi even cited it by name about T cells in cov 2 infection

She must not have read it, lol, because it says the same thing I did, that memory t cells were harming pubmed.ncbi.nlm.nih.gov/33277181/

Next time I will be smart about making my write-ups more optimistic and accessible. It's got great paragraph headers.

Mine is all doom-y and even has apoptosis in the title. Noone wants to hear about that, lol frontiersin.org/articles/10.33…

Let's compare the paper to my preprint (left) in October 2020. we both discuss the lymphopenia, but I go straight to CD95 due to it's role, while they expanded on the pandemic and it's impact beforehand

we then discuss the aetological role of pathogenesis the cytokine storm may have. I claim it is not so clear on the left, and begin to implicate t cells

We both discuss the loss of Tregs AND the hyperactivation of T cells (mine are first 2)

We also both discuss the protection seen from Naive T cells as shown by Moderbacher et al. but I think they do not use this source.

And of course we both depict memory cells are contributing to more severity. Mine on left

https://twitter.com/fitterhappierAJ/status/1311646161955160066

oh yes, we also call it feed-forward, so they agree with me there, too.

It's nice having other immunologists agree, but I bet they would be hounded off twitter for being 'T cell contrarians' like I am

https://twitter.com/fitterhappierAJ/status/1297352624765894656

We both agree that the memory t cells are contributing to disease through their function- killing cells. They claim bystander activation, I claim superantigenic activation (left)

Superantigens cause bystander cd8 activation

I also implicate orf8 and Fas

https://twitter.com/KarlRobbins/status/1485263405988859905