Thread by @kateneuropsych

@drshepard_md @CThinkCentral A JUST MY TAKE FROM BOTH SIDES OF THE DESK THREAD: I do believe when all is said and done
1) psychiatric issues are primarily prodromal for underlying cellular dysfunction that portends an as yet undiagnosable subthreshold medical condition that will emerge
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@drshepard_md @CThinkCentral clinically 10-15-20- year's down the line (CVD, Diabetes cancer metabolic syndrome), inherited diseases many which are not well known or identified (because they are not looked for as causal) causing a huge delay in diagnosis
(see celiac disease, rare diseases, mito diseases
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@drshepard_md @CThinkCentral not to mention a full 1/3 to 1/2 of those with celiac disease DO NOT SHOW A + blood serum titer (see Mayo clinic June 2021 research) hypercholesterolemia channelopathies etc) and many more diseases that emerge slowly based on an imbalance (eg., HPA axis that drives a new
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@drshepard_md @CThinkCentral homeostatic set point that alters regular function such) that it sets you up for eventual disease processes that progress insidiously if not incrementally (see high levels of cortisol-> suppresses insulin not to mention appitite & then suddenly at 4pm when you're finally
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@drshepard_md @CThinkCentral starving, you grab a candy bar because you no longer have the energy or cognitive researve to think your way through to cooking, see disrupted sleep and hormones etc).

So yeah from where I sit it seems far more likely that mental illness as a PRODROMAL signature for an
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@drshepard_md @CThinkCentral underlying bio molecular imbalance in cellular functioning that's ignored. There's alot of money at invested and stake with our current POV, narratives organizations etc (I could say far more about this but thats is not where I'm heading with this thread).

2) Cumulatively
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@drshepard_md @CThinkCentral mental illness when you look at biochemistry over time across multiple different types has a curious group signature that strangely resembles AUTOIMMUNE DISEASES.

It would not surprise one bit if in 7 years or less it's discovered that psychiatric symptoms precede a
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@drshepard_md @CThinkCentral previously unidentified type of auto immune disease or is in itself an autoimmune disease. Even symptomatically that makes sense as it is the mind body attacking itself/the body and frankly the immune system is really your CNS in another form.

No other system in your body
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@drshepard_md @CThinkCentral is that deeply embedded nor wholly capable of altering the functioning of all systems such as your neuroendocrine metobolic set point AND your CNS other than the immune system.

That we don't heavily incorporate the immune system AS A SISTER PART of understanding the CNS
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@drshepard_md @CThinkCentral (yes I know we focus on the brain but YOUR WHOLE BODY IS A BRAIN) in Education, research and treatment seems crazy (yeah I said that word here because that is nuts) because on any good day psychmeds are approx 60% effective (can you say palliative care -meaning reduce not
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@drshepard_md @CThinkCentral cure) and the psychmeds that do have any kind of effecticay have all kinds of antiviral and/or immune system properties.

Then there's still the well known ratio for rate of recovery, the 30/30/30 formula that to this day remains stable after 2-3 centuries & the last 70 yrs
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@drshepard_md @CThinkCentral of modern research that SHOULD NOT BE ACCEPTED OR ACCEPTABLE (30%get better 30%stay t/same & 30% get worse).

GIVEN WE DONT KNOW HOW OR WHY PSYCHEDS WORK BEYOND THE ELEMENTARY (cause we're so busy looking in the brain) maybe we should be looking at where we know they do work
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@drshepard_md @CThinkCentral (or the immune system) and figuring out why they do and why the immune system needs that kind of help when pysch symptoms emerge (beyond the obvious of endogenous/exogenously driven elevated levels of cortisol-> elevates inflammation which is equally worthy of scrutiny
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@drshepard_md @CThinkCentral all on its own) and why when psychmeds work in that capacity (meaning your immune system) they seem to also reduce psychiatric symptoms...

After all that is a wholly logical trajectory for Education research and pharmacotherapeutics to take once you synthesize the evidence
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@drshepard_md @CThinkCentral across multiple domains.

The specialization cubbies we are all forced into is great for the lab but not for clinicals and not for life... In life, everything happens all at once as the mess that it us. While you can simplify in a lab those of us out here in treatment
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@drshepard_md @CThinkCentral MUST SYNTHESIZE COMPLEXITY because that's how life sickness and health all work!

For what it's worth, just my 2 cents
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