Hi Guys, Today I completed the slides that were needed to be posted as a video on YouTube on " The Microclots in COVID-19 and Long-Hauler". A friend here at Twitter requested for subtitles to be added to a previous video posted on YouTube, so I thought to post it here as a thread
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Disclaimer-Intro
Clinical Features in Long-COVID
Effects of Abnormal coagulation in COVID-19 and Long-COVID that may present with complex clinical features. 1- Clot is a mass of platelets and protein fibrin at the site of bleeding. Without a cut or injury, a clot formed is called a thrombus. A detached thrombus is an embolus.
In COVID and Long-COVID a single or combination of the following factors can cause tiny clots (thrombi) to be formed in small vessels that can decrease blood flow to tissues causing damage (ischemia).
A thrombus can get detached to become an embolus that travels in a vessel to totally obstruct the small vessel ahead and cause the death of the tissues supplied by the vessel. The organs shown can suffer from abnormal clotting activated by factors detailed in the previous tweet.
This is a complex unpublished slide that shows how immune response to residual SARS-CoV-2 proteins interacts with antibodies to cause microthrombi activation. Most if not all of the symptoms in Long-COVID and LH are related to the residual antigens and a sustained IgG interaction
Shown here is the complex interactions of clotting pathways and active players in COVID-19 and Long-COVID that lead to deleterious outcomes shown on the right side.
Many thanks for your views, I don't recommend any self-medication. Kindly let your physician decide what suits you best, and if your physician doesn't recognize Long-COVID or the symptoms of ME-CFS, kindly refer him/her to me for a complete neurological examination and fMRI.
Yesterday, when I was preparing this presentation the SARSCoV2 was seeding me. Today with 101 fever, lil cough and body aches gripped me. Did LFT with the result below, do you see a faint pink bar at T?
Keeping myself in isolation with usual remedies for now. Need your wishes..
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Recent Updates:
COVID-19 and the Brain: The Neuropathological Italian Experience on 33 Adult Autopsies
SARS-CoV-2 was detected in neurons with evidence of axonal damage in the medulla oblongata (see image for functions). Its detection here can be easily correlated with symptoms
Similar studies with SARS-CoV-2 mRNA detected in the medulla oblongata and brainstem were published previously, but these reports keep on coming. 1- nature.com/articles/s4159…
And for the awards of the top 5 Viral Infectious disease between 2019 - 2022, the winners are... 1. The one and the only, the mother of them all...SARSCoV2. 2. The evolving Monkeypox virus 3. The emerging Congo Virus in Iraq 4. The hepatitis viruses 5. The EBV reactivated...
It's a shame that....we didn't invest in protecting our species against deadly infections, instead invested in wars.
Top healthcare regulating bodies are run by politicians who don't give a sh!t to public health.
Check out the date on the posting below...
Tomato 🍅 virus???
SARS-CoV-2 RNA in the Cerebrospinal Fluid of a Patient with Long COVID
Case report
On 1 October 2020, a 42-year-old woman had a positive SARS-CoV-2 RT-PCR assay from her nasopharyngeal swab. At the time, she reported only cough and diarrhea.
On 23 November 2020, she had a recurrence of her previous mild viral illness-related symptoms and also developed a loss of smell and taste: her nasopharyngeal antigen test for SARS-CoV-2 was positive. Two weeks later, she became fatigued and developed anxiety, palpitations,
diarrhea, vertigo, and perioral tingling. On 27 January 2021, she was hospitalized with a progressive headache, dizziness, anxiety, palpitations, diarrhea, and panic attacks. Neurological examination revealed hyperreflexia in the lower limbs and malaise.
Drug Discovery in Long-COVID: Ongoing Approach and Future possibilities
This thread shares the thoughts on the possible treatment options for Long-COVID. The SARS-CoV-2 and its encoding proteins have now been established as a cause of many acute COVID-19 symptoms..
..that individuals have been seen to carry into the chronic phase of Long-COVID. Though caused by an initial SARS-CoV-2 infection, the protracted illness that follows after acute COVID has caused an illness called Long-COVID in millions of individuals.
Once the Long-COVID sets in, its signs and symptoms have been seen to fan out into vascular disease, neurological deficits, and inflammatory disorders that are not expected to have a single “Magic pill” to treat the disease spectrum the patients suffer in Long-COVID.
Caution Advised: There are others 1/3 I slept a few hours after being awake, with the ways of helping Long-COVID in my mind. I have a dream recall, as if I was in few years ahead of the present day. There were some non humans behind me as I was guiding them somewhere.
Long walk, but I was like to take them to a place where I wanted them to be..
I at last reached there, and stopped, and the ones behind me said, what?
I took them into a place,like a big hall, low lights, where many needing help were stationed, lying restless in there beds...
I turn back and say to the ones now far at my back and about to enter the place...
" There are others"...I woke up then..and kept repeating in a awaken state the same lines above for several times....
" There are others"...There are others....
Re: Decision Update Long-COVID Help 1/2 With overwhelming response to the previous tweet, I realized that my Twitter Profile is a public property now. Though I thought the links to not one, but 3 different R&D resources could help, but it has put in a huge emotional pressure...
on me. I am and will remain dedicated to all those who have DM me and will take their calls and advise. Also, it is my heartfelt commitment to do remarkable things for my Long-COVID family that will continue. Please forgive me on this, please.
I was trying to help and not to gain attention that I already have from you guys as a Twitter family here. I am sorry, but those who had DM me and the ones who want my advise on stuff, will continue to receive it for as long as it takes.
With Love
Mannan