Fascinating: a vast (>20k) gold-standard RCT has failed to find any benefit for vitamin D supplementation on mortality in older people:
"vitamin D supplementation is unlikely to have influence on all-cause mortality" sciencedirect.com/science/articl…
"vitamin D supplementation is unlikely to have influence on all-cause mortality" sciencedirect.com/science/articl…
This was a MASSIVE trial, that took place over more than 5 years, and thus is really quite a convincing answer to the question "can taking a vitamin D supplement reduce your risk of death if you don't have a diagnosed deficiency?"
Perhaps even more interestingly, even when stratifying by only those with reduced vitamin D levels, there was no benefit for supplementation
This does not necessarily mean that oral vitamin D supplements won't improve your health at all, but it does mean that taking them long-term probably does not have a benefit (potentially even if you do have a deficiency)
Ping @EricTopol @CaulfieldTim you might find this interesting!
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