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Eric Topol Profile picture
@EricTopol
Jan 28, 2022 • 7 tweets • 5 min read • Read on X
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Brief update on Omicron, and its BA.1 and BA.2 lineages (sisters)
1. Origin—the 3 theories for how this hyper-mutated version of the virus evolved
nature.com/articles/d4158… @nature
2. A great annotated graphic by @firefoxx66 of @nextstrain conveying the antigenic distance of Omicron's BA.1 and BA.2 from prior variants
nextstrain.org/ncov/gisaid/gl…
3. The BA.2 variant is spreading widely, throughout many countries in Europe and Asia, out-competing BA.1, indicating higher transmissibility. But the good news from yesterday's @UKHSA: vaccination + boost is holding up quite well; there's no indication of more immune evasion
4. Some countries where BA.2 (light purple) is making or has already made major inroads outcompeting BA.1 (purple) covariants.org
5. And there's a new thread from @trvrb covering these points and many others, with the conclusion that BA.2's impact of extending the length of time (longer tail) for the Omicron wave
6. More on this and it's excellent, by @Dereklowe
science.org/content/blog-p…
7. A new BA.2 dedicated report today from @UKHSA
The secondary attack rate for BA.2 compared with BA.1 is roughly 30% increased, reflecting a transmission edge
assets.publishing.service.gov.uk/government/upl…
And another invaluable @kallmemeg🧵takes you through the rest of it

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More from @EricTopol

Eric Topol Profile picture
Jun 12
For medical information, general AI frontier models (Google, OpenAI, Anthropic) outperformed specialized @EvidenceOpen and @UpToDate as assessed by 12 US clinicians, randomized and blinded to which model and extensive testing/benchmarks. This was not anticipated. @NatureMedicine
nature.com/articles/s4159…Image
>65% of US physicians use OpenEvidence, with 27 million prompts in April
nbcnews.com/tech/tech-news…Image
This exemplifies the paradox of medical AI implementation
erictopol.substack.com/p/the-paradox-…Image
Read 4 tweets
Eric Topol Profile picture
Jun 2
A new study links GLP-1 drugs and 30-35% reduced incidence of breast cancer, using matched-pair propensity analysis

Confirms other association studies but still no proofascopubs.org/doi/10.1200/OP…
Very good review on this topic, by @DanielJDrucker @NatureCancer
nature.com/articles/s4301…Image
@DanielJDrucker @NatureCancer Maybe
jamanetwork.com/journals/jaman…Image
Read 4 tweets
Eric Topol Profile picture
Apr 19
If you're interested in how AI grew up over the past 15 years, and where it's headed, this new book tells the story in a riveting, page-turner way. In the new Ground Truths with @scmallaby Image
In 2010, when @GoogleDeepMind was formed, well before deep learning was taking hold, @demishassabis predicted AGI by 2030 and called out the use of agents
@GoogleDeepMind @demishassabis This is pretty striking
(please excuse typo, DeepMind's) Image
Read 5 tweets
Eric Topol Profile picture
Jan 20
Physical activity and the reduction of all-cause mortality, from 2 very large prospective cohorts
1. The relationship is non-linear, suggesting a threshold effect for many types of exercise as seen below Image
2. Engaging in > 1 type of physical activity was generally correlated with better outcomes compared with 1 type (T1,2,3) Image
The @BMJMedicine was supposed to post this paper 2 hours ago but has failed to do. It is being covered by other means medicalxpress.com/news/2026-01-p…
Someday the link will be active!
dx.doi.org/10.1136/bmjmed… Image
Read 5 tweets
Eric Topol Profile picture
Jan 1
People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS bookImage
President Trump takes 325 mg aspirin/day. The randomized trials tested 75-81 mg/day. His doctors recommended low-dose aspirin for heart event prevention. That recommendation is ill-founded based upon best evidence in older individuals.
nejm.org/doi/full/10.10…
academic.oup.com/eurheartj/arti…Image
Aspirin dosing information
wsj.com/us-news/as-sig…
Read 4 tweets
Eric Topol Profile picture
Aug 14, 2025
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role
nature.com/articles/s4358…Image
Inflammaging: with aging comes untoward inflammation, a summary graphic
nature.com/articles/s4358…Image
The potential consequences of too youthful immune system in an older person —> autoimmunity
nature.com/articles/s4358…Image
Read 5 tweets

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