Sophia Profile picture
Jan 30 5 tweets 3 min read
@AmerAcadPeds, many changes since your 2021 statement opposing off-label vax:☑️Favorable safety & eff. data for 5-11; 0-2 trial success☑️Indirect protection from vaccinated reduced w/Omi☑️<5 EUA delayed☑️Rising <5 hospitalizations & more. Will you provide an update? #offlabelu5
@AmerAcadPeds Sources: 1. August statement from AAP aap.org/en/news-room/n…
@AmerAcadPeds 2. <5 hospitalizations rising higher in absolute terms AND relative to older peds age groups: covid.cdc.gov/covid-data-tra…
Another view (same source) shows how wildly out of proportion the <5 hospitalization rates are compared to previous waves. Now approaching levels in 18-49.
Notably, 0-4 is the only age group that remains 100% unvaccinated while also being highly exposed via childcare with limited (or no) ability to mask. Indirect protection from vaxxed household members also down with Omi. A perfect storm behind the data!

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More from @sophiacbess

Jan 27
Today, on #KidsVaccinesDay, I want to talk about an off-label *option* to vaccinate children < 5. Is that getting ahead of the science, you ask? No! The science and the ethics align in support of #offlabelU5. Read on… 🧵1/n
First, let’s talk about how we got here. What happened with Pfizer’s pediatric trial? @dr_kkjetelina did an excellent explainer on this topic. Bottom line: 3 mcg worked in kids 6m – 2 years, but the dose was too low for 2-5s. yourlocalepidemiologist.substack.com/p/why-did-the-…
Very important note: No safety signals were observed in either age group.
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