US lagging European peers by vaccine doses and boosters, especially notable in age 60+
"On December 20, 30% of people in the US over-65 had gone six months since receiving a second dose, compared with just 2% in Portugal; 5 per cent in England; and 7% in Denmark."
Graphic that shows differences in vaccination waning for US vs England, Denmark and Portugal, age 60+
As I wrote in SUPER AGERS, the immune system is the key to modulating our aging process and the opportunity to extend healthspan. Today @NatureAging 7 new articles, summarized here, that reinforce its central role nature.com/articles/s4358…
The new special issue @ScienceMagazine features Immunity with 4 outstanding review papers, 5★
Our immune system over the lifespan, sex differences, influence on physiology, and host antiviral defenses science.org/toc/science/cu…
We've learned a lot more about the principal drivers of age-related diseases in the past few weeks. And that leads to a unified model to pull it all together. (open-access)
I review 4 new reports, summarized here: 1. The proteins from senescent cells predict age-related clinical outcomes 2. A new epigenetic age clock connects the dots between aging, the immune system, inflammation and lifestyle factors 3. People with a fast pace of aging had an increased risk of cognitive impairment, age-related diseases, disability, and mortality 4. The Importance of “Immune Resilience” for Healthspan
And present a unified I/I model for what we now know
Most people haven’t heard of this test, which is available in the US. It accurately predicts Alzheimer’s (not just if there’s a risk, but when). It is favorably affected by exercise and likely many other lifestyle factors.
Here’s (almost) everything we know about it. In Ground Truths (link in my profile d/t X-suppression)
A major @Nature paper this week found a significant decline in dementia after an outdated Shingles vaccine.
I've reviewed the study and many other relevant ones in a new Ground Truths (link in profile)
A Table from the post
The effect in the 2 natural experiments differed substantially by sex with the benefit predominant in women
The vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence
"implications are profound"
New @Nature nature.com/articles/s4158… nature.com/articles/d4158…