i learned today that quite a few ppl think that new research has _solved aging_. they don’t think the comparisons to old fountain-of-youth claims are fair. i could be wrong but i don’t think most of the believers know as much as i do
https://twitter.com/charlesmbrenner/status/1489228043088384005
about model bias, confirmation bias, replicability, what single genes can & cannot do, & how hard it is to put the genie back in the bottle when great stories are told. some think i’m a downer but i’m telling you what biologists have understood for decades:
animals have evolved gene sets to pass on their gene sets. life is _amazing_. my life work is understanding metabolism, especially through the lens of 4 NAD coenzymes. our gene sets confer the ability to reproduce multiple times but haven’t been selected for longevity per se.
bowhead sharks have 1000s of genes that give all their organ systems the ability to find mates & reproduce for 100s of years. mice have genes that allow them to reproduce from their 3rd month through their 2nd year.
our human ancestors mostly spread their seed in their late teens, 20s & 30s. had there been 10 million yrs of 100 yr old guys as desirable daddies & older women as sex symbols, our gene set would be different. centenarian genetics does not nominate powerful single genes &
the track record of insulin receptor, sirtuin & other genes as reproducible longevity genes in mice is abysmal. if you think the newest reports are somehow different from all that preceded them, ok but realize the same ppl who still cite known artifacts are promoting them.
YOU CAN AGE BETTER & i surely want you to. i even think that boosting NAD w NR can protect ppl from many conditions of metabolic stress, potentially improving DNA repair, improving viral defenses & lowering inflammation. but this is health maintenance. it’s not aging in reverse☮️
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