Alina Chan Profile picture
Feb 8 13 tweets 3 min read
An oldie but a goodie.
"Particularly sensitive is the mine shaft where the closest relative of the COVID-19 virus.. was discovered after an outbreak in 2012.. Wuhan Institute of Virology and the China CDC both studied bat coronaviruses from this shaft."
apnews.com/article/united…
I don't buy that elite scientists in China - Wuhan Institute of Virology, Chinese CDC director's lab, Beijing Institute of Pathogen Biology - scoured the Mojiang mine repeatedly over years for bat coronaviruses without thinking the miners were likely infected by a 🦇coronavirus.
These top scientists literally sampled the shit out of thousands of bats, rodents and other animals in that mine for years - testing every sample for viruses that might potentially infect humans.

And some people think they did not suspect the miners had been felled by a virus?
The first public coverage of one of these virus sampling expeditions said they were looking for a killer virus.
science.org/content/articl…
I'm not sure how much spare time and energy people think top scientists have that they would organize extensive spelunking trips into abandoned mineshafts to collect thousands of potential pathogen samples for no good reason.
Between the years 2012-2015 alone, the Wuhan Institute of Virology group went to the mine once or twice a year and collected 1,322 samples to test for viruses.

Did they do all this for no good reason considering other more SARS-infested caves in the area?
nature.com/articles/s4158…
I'd like to see this research grant proposal.

"We would like half a million dollars to thoroughly investigate a mine where no SARS-like virus or human viral pathogen of interest has ever been identified or suspected to circulate."
No need to mention that the doctors treating the miners had concluded:

"Analysis of these cases of severe pneumonia by an unknown virus.. may be caused by "SARS-like CoV" or "bat SARS-like coronavirus" from Chinese horseshoe bats."
No need to mention this either:
经钟南山院士会诊、取样后, 武汉病毒研究所测得患者血清抗体阳性, 提示存在病毒感染。
"After consulting Zhong Nanshan, the Wuhan Institute of Virology found that the patient's serum antibody was positive, indicating the existence of viral infection."
No need to mention that Zhong Nanshan, one of China's foremost SARS experts, was the one who instructed investigators to determine the type of bat in the mine and test the patients for SARS antibodies.
The cases of severe pneumonia in the miners were so arresting that the bats in the mine were also investigated for viruses by the Chinese CDC director's lab and described in a 2016 thesis.
4名病例血液标本检测结果显示:4人均携带SARS病毒 IgG抗体,其中出院2人的抗体水平较高, 住 院2人的抗体水平较低(中国科学院武汉病毒学研究所)。

The 4 cases all carried SARS virus IgG antibodies. The test was done by the Wuhan Institute of Virology, Chinese Academy of Sciences.
Please keep this thread in mind if you read about any expert or reporter claiming there was nothing interesting about the Mojiang miners and that an infection by bat virus was not suspected.

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More from @Ayjchan

Feb 9
2 early takeaways from this saga:

1. Chinese scientists asked @NIH NCBI database to delete deposited data containing sequences of early versions of SARS-CoV-2 virus.

2. US-based @biorxivpreprint blocked European scientists from posting their analysis of this data as a preprint.
Never thought I'd ask this, but... @biorxivpreprint @cshperspectives

What is bioRxiv's gatekeeping policy when it comes to original analyses? And would you consider a more transparent approach to this gatekeeping by publishing the name of the reviewer and reason for rejection?
@biorxivpreprint @cshperspectives Although bioRxiv is not a peer review service, it still confers a certain level of credibility to the preprints it has screened.

Has the team at bioRxiv considered that now there may be conflicts of interest among its screeners that should be carefully managed?
Read 5 tweets
Feb 8
What a difference a year can make.

March 2021:
"many virologists also remain unconvinced by the idea that SARS-CoV-2 was engineered"
buzzfeednews.com/article/petera…
May 2021:
"More investigation is still needed to determine the origin of the pandemic. Theories of accidental release from a lab and zoonotic spillover both remain viable. Knowing how COVID-19 emerged is critical..."
science.org/doi/10.1126/sc…
June 2021:
"You can't distinguish between the two origins from just looking at the sequence. So, naturally, you want to know were there people in the virology laboratory in Wuhan who were manipulating viral genetic sequences?"
caltech.edu/about/news/the…
Read 6 tweets
Feb 8
It troubles me that there are emails and documents located here in the USA which can tell us what SARS-like viruses and rare cleavage sites scientists in Wuhan had discovered.

Why are these not being subpoena'ed so that we can end speculation about #OriginOfCovid?
I keep seeing tweets about not being able to investigate the #OriginOfCovid unless the Chinese government lets us. If you think it through, there is so much info, documentation & communications scattered around the world. A lot of it here in the USA. We've known this since 2020.
The numerous scientists, many here in the US and some in other countries, who were part of the DEFUSE proposal just kept mum about their 2018 furin cleavage site insertion pipeline for nearly 2 years until some anonymous person leaked it.
Read 5 tweets
Feb 7
I'm grateful for the growing number of scientists and science reporters who are advocating for a credible investigation of both natural and lab #OriginOfCovid hypotheses.

People in the future need to be able to look back and see that some scientists have integrity & courage.
Knowing that there are checks and balances in our research system (including its funding, publication, and media reporting), and people to actually enforce those checks and balances, builds the bedrock of public trust in science.
If the #OriginOfCovid is traced to research activities, it would make me most relieved if scientists played a prominent role in investigating and determining the origin - and not in covering it up or suppressing an investigation out of self-preservation or fear.
Read 6 tweets
Feb 6
I think it's in poor form for @ScienceAdvances to have published this latest piece by EcoHealth/Daszak et al. without asking them to elaborate on how exactly they will work on improving the safety + transparency of virus discovery work.
h/t @TheSeeker268
science.org/doi/10.1126/sc…
@ScienceAdvances @TheSeeker268 "... for viral discovery, we chose to use the proposed budget of the Global Virome Project, a decade-long project that seeks to identify 70% of the unknown potentially zoonotic viruses in wildlife globally. It has an estimated budget of $120 million to $340 million per year."
@ScienceAdvances @TheSeeker268 I'd really like to know if any of the peer reviewers challenged this claim in the paper:

"Humanity needs a global viral discovery project if we are to prevent future pandemics."

How did all the virus discovery work in the past decade help to prevent pandemics?
Read 15 tweets
Feb 5
Will specific steps for investigating both natural and lab #OriginOfCovid scenarios be clearly laid out?
I'm concerned about the SAGO process of figuring out how to track the #OriginOfCovid because apparently one of the experts in the original China-WHO team didn't know that viruses are cultured at the Wuhan Institute of Virology.
Which might explain why he could not think of a way to investigate a lab #OriginOfCovid
Read 4 tweets

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