Thread by @VerwerftJan

Excited to share our paper with @AndreasGevaert and @FH_Verbrugge @HartcentrumH @HerbotsLieven @guido_claessen @PaulDendale
doi.org/10.3389/fcvm.2…
We know that systolic reserve is reduced in #HFpEF; but can systolic reserve help in the diagnosis🤔?

22 pts with simultaneous #iCPET and #ExerciseEchocardiography: Elevated
exPAWP (≥25 mmHg = elevate LVFP) was present in 14 patients, and was best identified by peak septal systolic annular velocity <9.5 cm/s (exS’) with an AUC of 0.97

second best non-invasive mPAP/CO slope ≥3.2 mmHg/L with AUC 0.88 (with systematic use of agitated colloid for determining TR gradient

We propose a decision tree to identify patients with elevated exPAWP. Applying this decision tree to 326 patients in an independent non-invasive DST cohort showed that patients labeled as “high probability of HFpEF” (n = 85) had reduced peak oxygen uptake and high H2FPEF score

E/e' has high specificity. Adding S' and mPAP/CO slope to exE/e' could increase sensitivity without loosing specificity

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