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Jan Verwerft Profile picture
Jan Verwerft
@VerwerftJan
Cardiologist 🇧🇪 | ExerciseEchocardiography | HeartFailure | ValvularHeartDisease | @JessaZiekenhuis | @hartcentrumh
Jan 2 • 10 tweets • 3 min read
🧵 New paper in Journal of Cardiac Failure
How does atrial fibrillation affect exercise hemodynamics in HFpEF?
🫀🫁🚴 =#CPETecho
We combined CPET with echocardiography to dissect the mechanisms 👇
led by 🌟@S_FoulkesAEP @_Sara_Ferreira @mhaykows 🌟

#HFpEF #AtrialFibrillation Highlights • Persistent AF, but not paroxysmal AF, exacerbates VO2peak limitations in HFpEF. • Lower VO2peak in persistent AF is due to lower peak exercise CO and SV. • Patients with persistent also AF had lower LVEDV at rest and during exercise. • In HFpEF, AF does not significantly modulate mPAP at rest or during exercise. Visual Take Home Graphic. The impact of atrial fibrillation on VO2peak, it’s Fick determinants and exercise hemodynamics in patients with HFpEF. Persistent AF (AFPersist), but not AFParox, exacerbates VO2peak limitations in HFpEF due to lower peak exercise CO and SV. I... 1/8
 In a large HFpEF cohort undergoing CPETecho, we compared
• Sinus rhythm
• Paroxysmal AF
• Persistent AF
at the time of exercise testing Image
Jun 15, 2024 • 15 tweets • 4 min read
Check out our latest 📄 🇧🇪🇨🇦🇦🇺

The Oxygen Cascade According to HFpEF Likelihood: A Focus on Sex Differences | JACC: Advances



Regardless of #HFpEF probability scores, ♀ have ⬇️peak VO2 than ♂ ⏪ ⬇️ O2 delivery &⬇️ O2 extraction

🧵1/14
Background: bit.ly/4epUf9q
Image 2/14
Method: combined CPET and #ExerciseEchocardiography in a dyspnea clinic
no EF < 50%, no history of HF, no more than mild pulmonary disease and valvular heart disease
Feb 9, 2022 • 14 tweets • 36 min read
Excited to share our paper with @AndreasGevaert and @FH_Verbrugge @HartcentrumH @HerbotsLieven @guido_claessen @PaulDendale
doi.org/10.3389/fcvm.2…
We know that systolic reserve is reduced in #HFpEF; but can systolic reserve help in the diagnosis🤔? 22 pts with simultaneous #iCPET and #ExerciseEchocardiography: Elevated
exPAWP (≥25 mmHg = elevate LVFP) was present in 14 patients, and was best identified by peak septal systolic annular velocity <9.5 cm/s (exS’) with an AUC of 0.97