a painter stares studiously at an egg—THAT WHICH IS
as he paints a bird on the canvas—THAT WHICH MAY BE
It's an egg—AND YET—it will be a bird
Through combination, transformation…
6/TIME ARBITRAGE—is the main advantage available to all
seized by few
Like the coupling of butterflies fluttering above AND below aware of eachother—OPAQUE to PROBABILITY—valuations fluctuate above + below volatiley
Any investment is
the pairing of an ALLOCATION + an ASSUMPTION
7/ Margin debt at $910B = highest level ever
wild swings are symptomatic of high-startle response from high uncertainty that some may know something that others don’t—when mostly NOBODY knows NOTHING
market reversion to the MEAN
MEANS a reversion to lower exit values
8/ All US recessions have been preceded by an INVERTED YIELD CURVE—though not every inverted curve was followed by a recession
We see potential for “BIFLATION”
AND
environmentalists have TOO QUICKLY overlooked the severe economic pain of switching TOO QUICKLY from coal + natgas
9/“Occupy Fed” movement is possible
Govt’s can lose control AND govts can take it
Global TECH challenges + opportunities
-US vs China vs Russia
-African continent
-Capital vs Labor
-Space Race 2.0
On “Consilience”—the unity of knowledge from different disciplines…
10/ INVENTIONS
everything NEW comes from synthetic combinations
of everything OLD
PEOPLE
all of us contain MULTITUDES
Founders can be:
brilliant AND irascible
polarizing AND genius
compassionate AND careless
wordsmiths AND inumerates
great storytellers AND terrible operators
11/ invention of new tech can solve PAST problems AND create future problems to be solved by FUTURE tech
—“Yes AND”
An overlooked science AND an unknown but hungry founding tech team AND a terrifyingly ambitious dream––its crazy!..
AND YET…that’s what we search for every day
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CZI led by Mark Zuckerberg + Priscilla Chan who've admirably committed tens of billions (and the entirety of their wealth to CZI) has acquired Lux family co Evolutionary Scale––just 2yrs after it's founding at a great multiple...
2/ We first teamed w/ @alexrives cofounder of EvolutionaryScale ~10yrs ago
cofounding Lux family Kallyope (cutting-edge bioetch focused on gut-brain axis)
Alex had the prescience to see the future of bio was computer science + AI. So he got his PhD at NYU and then...
@alexrives 3/...then Alex went to Meta, built an absolute cutting-edge AI bio group and published work that competed with Alphafold/Deepmind.
I tried to convince him to spinout in late winter of 2022––but Meta was funding him too well...
-Over 50% of small VCs will involuntarily exit as ~5 VCs are planning to voluntarily exit (IPO)
-Lux team has invested over half a billion dollars across 82 companies (new + existing) in the past few months…
2/
-Zuck’s “ Poachapalooza 2025”
-L&A (License + Acquihire) is the new M&A
-the AI capex surge (5% of GDP) ~ fiber-optic + router binge of 2000 tech boom (5.2%) and short step below sheet-rock bonanza of 2005 housing bubble (6.7%).
-Open source vs Closed…
3/great irony in frenzy for ARTIFICIAL intelligence––what’s acquired isnt hardware but HUMAN intelligence
-frontier of agentic Al not defined by model size-but what we can verify
-99% reliable agent degrades to 60.5% after 50 sequential decision tasks––each error cascading like cracks in glass
NVDA = 19% of that––and 42% of NVDA revenue comes from just 5 Big Tech co's buying GPUs:
Meta, Amazon, Microsoft, Google, Tesla
2/At recent lunch with LP who put Lux in business I talked about shift from consensus cloud inference (GPUs + datacenters + power) to on-device inference (memory + batteries)...
3/ This valued LP talked about CAPEX:
Meta, AMZN, MSFT, GOOG TLSA spending $560B by EOY 2025