1/ Preview of a speculative hypothesis

hormuz > fertilizer shortage > vulnerable food supply chain > food insecurity > existing migratory pressures exacerbated > peripheral country crisis in EU
=mkts 📉

unassimilated immigrants + rise of Right > violent clashes in EU
=mkts 📉 2/ Complex systems (via @sfiscience) fail not from obvious blows

but from seemingly inconsequential events (a "single spark") igniting volatile _ pre-existing conditions.

endless historical precedents of small spark collrelations: ex #1 Russian Wheat > Arab Spring...

1/ On Feb 21 I told my boss aka my wife @LTwolfe that I had my third conviction call not yet appreciated + to buy a basket

*In 2016 it was NVDA, pitched publicly at Invest For Kids in Chicago (80x+) when Lux portfolio company Zoox was using NVDA chips and I predicted the narrative would change from gaming consoles PS4/Xbox to simulation and AI… 2/ here was the 2016 tweet on NVDA…

https://twitter.com/wolfejosh/status/713834520974376960

1/ New paper from @ylecun et al on alternative approach for AI to learn more biologically...

paper basically says AI is super smart but still can't learn like a toddler can...

the main critique the main critique...

is that top models today dont learn once deployed.

and curating data + training pipelines + filtering out noise is all done by humans in loop instead of being an intrinsic skill of the AIs...

here's Claude explaining the paper simply

1/ The shift from GPU capex (NVDA) to memory intelligence is already underway (SK, Samsung, Micron).

What will be next?

Even the best HBM chips are constrained by how they get architected into systems... 2/ Nvidia's GPU racks have a fixed compute-to-memory ratio. It is baked in + hard to change.

It is GREAT for training––and a WALL for memory-intensive inference...

New Lux LP letter dropping this weekend... 2/ Q4 2025 Lux LP Letter…

1/Today at private investor gathering I pitched

LONG
Adobe (ADBE)

SHORT
basket of scientific publishers
Wiley
Elsevier
Springer Nature

AI overestimation oversold Adobe (down 40%)

AI underestimation along with 2 other catalysts is set to crack the oligopoly of publishers 2/ first $ADBE thesis then the short basket + weighting

reasonably clean dislocation in large-cap SW

Stock ~$325 (down ~40% from highs)

Mult compressed from ~40x to ~20x

EV/EBITDA ~11–12x (10yr low)

mkt sees "value trap" facing existential AI threat

I see category error

1/ We are ABSOLUTELY insanely lucky to be able to witness this conversation

MASTERCLASS in military + geopolitical strategy + Arab/Israeli conflict

@havivrettiggur's brilliance+ Dan Schueftan's realpolitik rationality

watch whole thing or pick any segment🤯 2/Key excerpts (summarized).
Hard to disagree with anything.

The Nature of the Enemy + "Barbarism"

The Definition of Barbarism: Barbarism is not just violence; it is a societal decision to value the death of the enemy over the lives of one's own children. When Hamas places weapons in tunnels but forces civilians to stay above ground during war, they are declaring that they do not care for their own survival, only the destruction of Jews.

The "Love of Death" is Literal: We must stop projecting Western rationalism onto enemies who openly declare, "You Jews will lose because you love life; we will win because we love death." This is not a slogan; it is a strategic doctrine that renders traditional deterrence mechanisms (like threat of death) ineffective.

The Danger of "Happy Wife, Happy Life" Geopolitics: The Western belief that economic prosperity ("a better life") leads to moderation is a fatal fallacy. The Second Intifada was launched when Palestinians had their best economic situation in history. You cannot buy off an ideology that considers killing Jews a higher calling than feeding children.

Culture is Deterministic: You cannot "de-radicalize" a society that does not want to change. Just as Libya’s failure is cultural rather than resource-based, Gaza’s failure is rooted in a culture where the only role models are those who kill Jews. The West’s refusal to discuss culture—viewing it as "progressive" to ignore it—blinds them to reality.

1/ 🚨Today history in AI 💻+ biology 🧬was made!

CZI led by Mark Zuckerberg + Priscilla Chan who've admirably committed tens of billions (and the entirety of their wealth to CZI) has acquired Lux family co Evolutionary Scale––just 2yrs after it's founding at a great multiple... 2/ We first teamed w/ @alexrives cofounder of EvolutionaryScale ~10yrs ago

cofounding Lux family Kallyope (cutting-edge bioetch focused on gut-brain axis)

Alex had the prescience to see the future of bio was computer science + AI. So he got his PhD at NYU and then...

1/ why Quantum is BULLSHIT

"paving a path towards potential future"

like saying: 'Working towards possibility of maybe a thing that might one day be a breakthrough if a breakthrough were to maybe occur'

Here I assemble just 2005 to 2015 annual headlines or this BULLSHIT

https://twitter.com/sundarpichai/status/1981013746698100811

2/ I could start in the 90s. But let's just go thru 20yrs of BULLSHIT

2005...

1/ Revealing Lux's latest

a $101M launch of new cutting-edge biotech created from one the most important scientific breakthrus Lux has seen in many yrs!

NILO

control IMMUNE system 🦠
via NERVOUS system 🧠...

we stealth funded last yr before this NATURE paper got published👇
2/ THE BIG IDEA?

Your brain has a direct hotline to your immune system.

Specific neurons in the vagus nerve detect inflammatory signals + then tell your brainstem to dial inflammation up or down.

When our team cut this connection immune responses went completely haywire!

1/ Apple researchers just dropped NEW foundation model on BEHAVIORAL data from wearables.

Forget raw sensors—think steps, heart variability, gait

Trained on 2.5B hours via 162K people

Predicts age, sex, pregnancy, sleep like a crystal ball. 2/ Their new foundation model (WBM) trained not on noisy low-level sensor data––but on derived behavioral metrics via wearables

Outperforms raw sensor models in predicting sleep, injury, & infection.

When combined CRUSH it—predicting pregnancy w/ >90% accuracy.

1/ New Lux quarterly LP letter––Q2 2025

theme: “Friction Frontier”

-Over 50% of small VCs will involuntarily exit as ~5 VCs are planning to voluntarily exit (IPO)

-Lux team has invested over half a billion dollars across 82 companies (new + existing) in the past few months…
2/
-Zuck’s “ Poachapalooza 2025”

-L&A (License + Acquihire) is the new M&A

-the AI capex surge (5% of GDP) ~ fiber-optic + router binge of 2000 tech boom (5.2%) and short step below sheet-rock bonanza of 2005 housing bubble (6.7%).

-Open source vs Closed…

1/ Beyond the hype + headlines

some eye-opening AI stats to consider

Today Mag 7 = 35% of US stock mkt value

NVDA = 19% of that––and 42% of NVDA revenue comes from just 5 Big Tech co's buying GPUs:

Meta, Amazon, Microsoft, Google, Tesla 2/At recent lunch with LP who put Lux in business I talked about shift from consensus cloud inference (GPUs + datacenters + power) to on-device inference (memory + batteries)...

1/ This was played perfectly thus far

US plausible deniability while coordinating with Israel🇮🇱🇺🇸

Trump does not want war
Trump says diplomacy diplomacy diplomacy
Trump gave a deadline of 60 days
Israel moved on day 61

There were breadcrumbs...a 🧵of how we know that we knew 2/ Trump a few days ago

When asked about decision to let U.S. military dependents depart Middle East, President Trump offered no explanation, mysteriously stating, “You’ll have to see, thank you,” before departing the White House.

Apple just GaryMarcus'd LLM reasoning ability 2/ Apple tested today's "reasoning" AIs like Claude + DeepSeek which look smart—but when complexity rises, they collapse.

Not fail gracefully. Collapse completely.

1/ Three big Lux things tonight

-@anduriltech founder Palmer Luckey on @60Minutes
“The Future of Warfare”

-@eGenesisBio on @CNN with Sanjay Gupta
“Animal Pharm”

-new Lux Q1 2025 Quarterly Letter

2/
This is one of my favorite letters we’ve ever written

The theme is PARTNERSHIPS

-between man and machine
-between present and future selves, decision, companies
-between us and our founders of Lux companies
-between Lux partners ourselves

BIG NEWS from Lux🚨…

American scientists––and those we attract to America🇺🇸––are what have helped make America not just great but absolutely + relatively EXCEPTIONAL.

We CANNOT cede scientific supremacy to China.
We don’t need talk, we need action…

https://twitter.com/lux_capital/status/1920901869594902655

2/ The 🇨🇳CCP “2035 Science & Technology Vision” states unapologetically “original innovation is the sharpest blade.” coupling that declaration w/ vast subsidies, talent visas + procurement guarantees which have helped them take lead in 37 of 44 critical and emerging technologies!

1/ My take on Trump in exchange with one of my smartest market friends.

Bizarrely I’m more sanguine.

Either it’s the greatest policy mistake and blunder of a rollout ever. OR it ends up with some grand bargain for those that want to ensure certainty and stability by doing long term deals or otherwise face massive undulating volatility in his flip-flopping, fickle whims.

I think overall across all domains (tech cos, universities, law firms, countries) they got very confident and then cocky ... I think it started with the Silicon Valley and Elon flip over… And then Zuck shifting his board and taking a knee… And he saw powerful person after powerful person pledging fealty out of fear. I think that further emboldened them the "we’re fucking here We are in total control. We have all the leverage. You do what we say or you're fucked" from big tech to Zelensky to law firms to Columbia + Harvard and then the rest of the world

And Whether it’s the market fighting back or law firms, fighting back or universities fighting back… He’s gotta double down and not show weakness or concede. He was wrong… It’s very tough game theory.

The other view… Is they try a few experiments mindful that it could create chaos… And going into midterms they stabilized with more predictability market so and they have total political control 2/ post election when all Trump bros were “golden age of America” with 80s topgun hulk hogan f-yeah amurica hype videos…

We bought deep out of the money puts

Because the consensus and stability were the consensus view and the scarce contrarian view was: insane volatility ahead

1/ New Q4 Lux letter to LPs… 2/

1/ an urgent wake-up call ⏰

A new bombshell report just dropped.

China’s playbook isn’t war in the open—it’s war in the seams.

They target the gaps between state & federal, public & private, markets & security.

America must 'armor up' 🧵... 2/ The CCP’s strategy?

Hollow out U.S. strength from within.

Critical infrastructure? Infiltrated.
Universities? Compromised.
State pension funds? Financing China’s military tech.

1/ QATAR -

If you were fly on wall in Qatar's strategy meetings you’d hear their not so secret strategy

i) keep up economic relations w/Iran (esp w shared gas reserves)

ii) support Islamist groups (esp Muslim Brotherhood) + use the masses as pawns for political leverage.. 2/

iii) assert distinct identity in MidEast geopolitics as a ‘mediator’

iv) religious mafia style––foment fervent believers (funding Al Jazeera propoganda + mosques/ Imams to rule over other country populations) grow geopolitical power depsite tiny size (and no real military)