1) What are the risks associated with NSAID use? A short thread 💊💊 
2) NSAID’s are responsible for approximately 30% of hospital admissions that occur secondary to preventable adverse drug reactions (Davis & Robson, 2016). 1 adverse effect is they can potentially increase systolic BP by 5mmHg
3) NSAID’s will inhibit platelet cyclooxygenase & formation of thromboxane A2. A fancy term for reducing clotting within the blood which increases the risk of bleeding. This is an extremely common side effect, particularly in the elderly, liver disease or ++ alcohol intake.
4) NSAID’s also increase the risk of bronchospasm due to a reduction in anti-inflammatory prostglandins. This can overproduce inflammatory leukotrienes which may exacerbate asthma Sx in approx 5-10% pt’s
5) NSAID’s could also induce hypoglycaemia in diabetic patients. This is because they influence ion channels and stimulate oversecretion of insulin which reduces blood sugar
6) NICE Guidelines suggest the following our high risk pt’s; a) >65yrs, b) HTN, c) Diabetic, d) CVD, e) renal or liver impairment, f) Hx of ulcers / GI bleeding. Topical NSAID’s and low dose paracetamol are recommended instead of this
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