A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications | Biochemical Journal | Portland Press. portlandpress.com/biochemj/artic…
“These microclots are more-or-less easily measured in PPP with the stain thioflavin T and a simple fluorescence microscope. Although the symptoms of Long COVID are multifarious, we here argue that . .
the ability of these fibrin amyloid microclots (fibrinaloids) to block up capillaries, and thus to limit the passage of red blood cells and hence O2 exchange, can actually underpin the majority of these symptoms.” #anticoagulants #LongCovid
Authors suggest triple anticoag treatment of 1 month of dual antiplatelet therapy (DAPT) (Clopidogrel 75 mg/Aspirin 75 mg) once a day, and oral anticoagulant (DOAC) (Apixiban) 5 mg twice a day, together with a proton pump inhibitor (PPI) e.g. pantoprazole 40 mg/day to protect GI.
Addressing only one of the pathologies (either clot pathologies or platelet hyperactivation) will always tend to fail, as was also noted in recent clinical trials.
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